thalidomide has been researched along with Periodontitis in 2 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Periodontitis: Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alveolar bone loss was evaluated by the sum of the distances between the cusp tip and the alveolar bone along the axis of each molar root, subtracting from the contralateral side." | 1.32 | Effects of tumor necrosis factor-alpha inhibitors pentoxifylline and thalidomide on alveolar bone loss in short-term experimental periodontal disease in rats. ( Brito, GA; Lima, V; Ribeiro, RA; Rocha, FA; Vidal, FD, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baek, MC | 1 |
| Jung, B | 1 |
| Kang, H | 1 |
| Lee, HS | 1 |
| Bae, JS | 1 |
| Lima, V | 1 |
| Vidal, FD | 1 |
| Rocha, FA | 1 |
| Brito, GA | 1 |
| Ribeiro, RA | 1 |
1 review available for thalidomide and Periodontitis
| Article | Year |
|---|---|
Novel insight into drug repositioning: Methylthiouracil as a case in point.
Topics: Animals; Anti-Inflammatory Agents; Antithyroid Agents; Arthritis, Rheumatoid; Biomarkers; Doxycyclin | 2015 |
1 other study available for thalidomide and Periodontitis
| Article | Year |
|---|---|
Effects of tumor necrosis factor-alpha inhibitors pentoxifylline and thalidomide on alveolar bone loss in short-term experimental periodontal disease in rats.
Topics: Alveolar Bone Loss; Analysis of Variance; Animals; Anti-Inflammatory Agents; Ligation; Male; Pentoxi | 2004 |