thalidomide has been researched along with Pancreatitis in 6 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Pancreatitis: INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was designed to investigate the preventive effect of thalidomide on acute pancreatitis-associated liver injury in the rat and analyze its relationship with oxidative stress." | 7.81 | Protective Effect of Thalidomide on Liver Injury in Rats with Acute Pancreatitis via Inhibition of Oxidative Stress. ( Fan, LJ; Li, HY; Liu, J; Lv, P; Meng, QS, 2015) |
| "We studied the effect of thalidomide on NFκB-induced TNF-α in acute pancreatitis-associated lung injury in the rat." | 7.80 | Thalidomide alleviates acute pancreatitis-associated lung injury via down-regulation of NFκB induced TNF-α. ( Fan, LJ; Ji, SS; Li, HY; Li, W; Lv, P, 2014) |
| "Pretreatment with pomalidomide significantly reduced the plasma levels of amylase and lipase; the histological injury; and the expression of TNF-α, IL-1β, monocyte chemotactic protein-1 (MCP-1), and inducible nitric oxide synthase (iNOS) in cerulein-induced acute pancreatitis." | 7.77 | Pomalidomide suppresses cerulein-induced acute pancreatitis in mice. ( Chen, C; Chen, SH; Chiu, TH; Huang, YT; Tsai, MJ, 2011) |
| "A total of 200 mg/kg thalidomide was given intragastric once a day (total 8 days) before the experimental models of post-ERCP pancreatitis were established." | 7.74 | Effects of thalidomide in experimental models of post-endoscopic retrograde cholangiopancreatography pancreatitis. ( Mo, JZ; Wang, ZH; Wu, SM; Xiao, SD; Xiong, GS, 2007) |
| "This study was designed to investigate the preventive effect of thalidomide on acute pancreatitis-associated liver injury in the rat and analyze its relationship with oxidative stress." | 3.81 | Protective Effect of Thalidomide on Liver Injury in Rats with Acute Pancreatitis via Inhibition of Oxidative Stress. ( Fan, LJ; Li, HY; Liu, J; Lv, P; Meng, QS, 2015) |
| "We studied the effect of thalidomide on NFκB-induced TNF-α in acute pancreatitis-associated lung injury in the rat." | 3.80 | Thalidomide alleviates acute pancreatitis-associated lung injury via down-regulation of NFκB induced TNF-α. ( Fan, LJ; Ji, SS; Li, HY; Li, W; Lv, P, 2014) |
| "Pretreatment with pomalidomide significantly reduced the plasma levels of amylase and lipase; the histological injury; and the expression of TNF-α, IL-1β, monocyte chemotactic protein-1 (MCP-1), and inducible nitric oxide synthase (iNOS) in cerulein-induced acute pancreatitis." | 3.77 | Pomalidomide suppresses cerulein-induced acute pancreatitis in mice. ( Chen, C; Chen, SH; Chiu, TH; Huang, YT; Tsai, MJ, 2011) |
| "A total of 200 mg/kg thalidomide was given intragastric once a day (total 8 days) before the experimental models of post-ERCP pancreatitis were established." | 3.74 | Effects of thalidomide in experimental models of post-endoscopic retrograde cholangiopancreatography pancreatitis. ( Mo, JZ; Wang, ZH; Wu, SM; Xiao, SD; Xiong, GS, 2007) |
| "Acute pancreatitis was induced in Swiss mice by five intraperitoneal injections of cerulein (50 μg/kg), at 1 h intervals." | 1.37 | Anti-inflammatory effect of α,β-amyrin, a triterpene from Protium heptaphyllum, on cerulein-induced acute pancreatitis in mice. ( Brito, GA; Chaves, MH; Melo, CM; Morais, TC; Rao, VS; Santos, FA; Tomé, AR, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lv, P | 2 |
| Li, HY | 2 |
| Ji, SS | 1 |
| Li, W | 1 |
| Fan, LJ | 2 |
| Meng, QS | 1 |
| Liu, J | 1 |
| Melo, CM | 1 |
| Morais, TC | 1 |
| Tomé, AR | 1 |
| Brito, GA | 1 |
| Chaves, MH | 1 |
| Rao, VS | 1 |
| Santos, FA | 1 |
| Tsai, MJ | 1 |
| Chen, C | 1 |
| Chen, SH | 1 |
| Huang, YT | 1 |
| Chiu, TH | 1 |
| Xiong, GS | 1 |
| Wu, SM | 1 |
| Wang, ZH | 1 |
| Mo, JZ | 1 |
| Xiao, SD | 1 |
| Chung, LW | 1 |
| Yeh, SP | 1 |
| Hsieh, CY | 1 |
| Liao, YM | 1 |
| Huang, HH | 1 |
| Lin, CY | 1 |
| Chiu, CF | 1 |
6 other studies available for thalidomide and Pancreatitis
| Article | Year |
|---|---|
Thalidomide alleviates acute pancreatitis-associated lung injury via down-regulation of NFκB induced TNF-α.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Down-Regulation; Immunosuppressive Agents; Lung; | 2014 |
Protective Effect of Thalidomide on Liver Injury in Rats with Acute Pancreatitis via Inhibition of Oxidative Stress.
Topics: Animals; Biomarkers; Glutathione Peroxidase; Intercellular Adhesion Molecule-1; Liver Diseases; Male | 2015 |
Anti-inflammatory effect of α,β-amyrin, a triterpene from Protium heptaphyllum, on cerulein-induced acute pancreatitis in mice.
Topics: Amylases; Animals; Anti-Inflammatory Agents; Burseraceae; Ceruletide; Disease Models, Animal; Immuno | 2011 |
Pomalidomide suppresses cerulein-induced acute pancreatitis in mice.
Topics: Acute Disease; Administration, Oral; Amylases; Animals; Ceruletide; Disease Models, Animal; Immunolo | 2011 |
Effects of thalidomide in experimental models of post-endoscopic retrograde cholangiopancreatography pancreatitis.
Topics: Animals; Cholangiopancreatography, Endoscopic Retrograde; Disease Models, Animal; Immunosuppressive | 2007 |
Life-threatening acute pancreatitis due to thalidomide therapy for chronic graft-versus-host disease.
Topics: Adolescent; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosu | 2008 |