thalidomide has been researched along with Pain, Postoperative in 2 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Pain, Postoperative: Pain during the period after surgery.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We used a rat model of postoperative pain to investigate the effects of intra-RVM thalidomide treatments on postoperative pain, and evaluate the role of cannabinoid receptors in the effects of intra-RVM thalidomide treatments on GABAergic neurotransmission in the RVM neurons." | 1.48 | Administrations of thalidomide into the rostral ventromedial medulla produce antinociceptive effects in a rat model of postoperative pain. ( Gu, K; Jiang, B; Li, Y; Ma, P; Ma, X; Song, T; Wang, C; Yang, Y; Zhao, J, 2018) |
| "Thalidomide (5-50mg/kg) was intraperitoneally administered immediately after laparotomy." | 1.46 | Thalidomide alleviates postoperative pain and spatial memory deficit in aged rats. ( Guo, P; Hu, SP, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Song, T | 1 |
| Ma, X | 1 |
| Ma, P | 1 |
| Gu, K | 1 |
| Zhao, J | 1 |
| Yang, Y | 1 |
| Jiang, B | 1 |
| Li, Y | 1 |
| Wang, C | 1 |
| Guo, P | 1 |
| Hu, SP | 1 |
2 other studies available for thalidomide and Pain, Postoperative
| Article | Year |
|---|---|
Administrations of thalidomide into the rostral ventromedial medulla produce antinociceptive effects in a rat model of postoperative pain.
Topics: Analgesics; Animals; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Antagonists | 2018 |
Thalidomide alleviates postoperative pain and spatial memory deficit in aged rats.
Topics: Acute Pain; Aging; Animals; Cytokines; Inflammation Mediators; Locomotion; Male; Memory Disorders; P | 2017 |