thalidomide has been researched along with Osteosclerosis in 4 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Osteosclerosis: An abnormal hardening or increased density of bone tissue.
| Excerpt | Relevance | Reference |
|---|---|---|
| "POEMS syndrome is a rare paraneoplastic condition associated to an underlying plasmacellular dyscrasia." | 5.38 | Efficacy of lenalidomide plus dexamethasone for POEMS syndrome relapsed after autologous peripheral stem-cell transplantation. ( Balducci, M; Chiusolo, P; De Stefano, V; Giannotta, C; Laurenti, L; Leone, G; Luigetti, M; Sabatelli, M; Sica, S; Sorà, F; Vannata, B, 2012) |
| "POEMS syndrome is a clonal plasma cell disease characterized by polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes." | 2.49 | New advances in the diagnosis and treatment of POEMS syndrome. ( Li, J; Zhou, DB, 2013) |
| "Lenalidomide therapy was started after the diagnosis and the patient had a favorable outcome." | 1.46 | Utility of osteosclerotic lesion biopsy in diagnosis of POEMS syndrome: A case report. ( Akiyama, H; Hara, D; Hasegawa, Y; Hoshikawa, M; Nukui, S; Shimizu, T, 2017) |
| "POEMS syndrome is a rare paraneoplastic condition associated to an underlying plasmacellular dyscrasia." | 1.38 | Efficacy of lenalidomide plus dexamethasone for POEMS syndrome relapsed after autologous peripheral stem-cell transplantation. ( Balducci, M; Chiusolo, P; De Stefano, V; Giannotta, C; Laurenti, L; Leone, G; Luigetti, M; Sabatelli, M; Sica, S; Sorà, F; Vannata, B, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hara, D | 1 |
| Akiyama, H | 1 |
| Nukui, S | 1 |
| Shimizu, T | 1 |
| Hoshikawa, M | 1 |
| Hasegawa, Y | 1 |
| Mohamed, M | 1 |
| Brain, T | 1 |
| Khalafallah, A | 1 |
| Vannata, B | 1 |
| Laurenti, L | 1 |
| Chiusolo, P | 1 |
| Sorà, F | 1 |
| Balducci, M | 1 |
| Sabatelli, M | 1 |
| Luigetti, M | 1 |
| Giannotta, C | 1 |
| De Stefano, V | 1 |
| Leone, G | 1 |
| Sica, S | 1 |
| Li, J | 1 |
| Zhou, DB | 1 |
1 review available for thalidomide and Osteosclerosis
| Article | Year |
|---|---|
New advances in the diagnosis and treatment of POEMS syndrome.
Topics: Antibodies, Monoclonal, Humanized; Bevacizumab; Boronic Acids; Bortezomib; Castleman Disease; Chromo | 2013 |
3 other studies available for thalidomide and Osteosclerosis
| Article | Year |
|---|---|
Utility of osteosclerotic lesion biopsy in diagnosis of POEMS syndrome: A case report.
Topics: Arthritis, Rheumatoid; Cell Proliferation; Diagnosis, Differential; Female; Humans; Immunoelectropho | 2017 |
Dramatic response of diffuse osteosclerosis secondary to multiple myeloma using thalidomide with melphalan and prednisolone.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Melphalan; Multiple Myeloma; O | 2014 |
Efficacy of lenalidomide plus dexamethasone for POEMS syndrome relapsed after autologous peripheral stem-cell transplantation.
Topics: Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Combined | 2012 |