thalidomide has been researched along with Osteosarcoma in 4 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Osteosarcoma: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether thalidomide inhibits the growth of primary and pulmonary metastatic canine osteosarcoma in mice after xenotransplantation." | 7.72 | Effect of thalidomide on growth and metastasis of canine osteosarcoma cells after xenotransplantation in athymic mice. ( Baldwin, JM; Detrisac, CJ; Farese, JP; Fox, LE; Roberts, SL; Van Gilder, JM, 2004) |
| "Thalidomide was added to osteosarcoma cells and studied by cytotoxicity assay, evaluating apoptosis, cell cycle arrest, mitochondrial membrane potential (ΔΨm), and reactive oxygen species (ROS) levels and the expression of Bcl‑2, Bax, caspase‑3 and NF‑κB." | 5.43 | Anticancer effect of thalidomide in vitro on human osteosarcoma cells. ( Guo, Q; Liu, S; Liu, Y; Wang, Y; Wu, Y; Xu, H; Yang, Y; Zhang, G; Zhu, J, 2016) |
| "To determine whether thalidomide inhibits the growth of primary and pulmonary metastatic canine osteosarcoma in mice after xenotransplantation." | 3.72 | Effect of thalidomide on growth and metastasis of canine osteosarcoma cells after xenotransplantation in athymic mice. ( Baldwin, JM; Detrisac, CJ; Farese, JP; Fox, LE; Roberts, SL; Van Gilder, JM, 2004) |
| "Thalidomide was added to osteosarcoma cells and studied by cytotoxicity assay, evaluating apoptosis, cell cycle arrest, mitochondrial membrane potential (ΔΨm), and reactive oxygen species (ROS) levels and the expression of Bcl‑2, Bax, caspase‑3 and NF‑κB." | 1.43 | Anticancer effect of thalidomide in vitro on human osteosarcoma cells. ( Guo, Q; Liu, S; Liu, Y; Wang, Y; Wu, Y; Xu, H; Yang, Y; Zhang, G; Zhu, J, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, J | 1 |
| Yang, Y | 1 |
| Liu, S | 1 |
| Xu, H | 1 |
| Wu, Y | 1 |
| Zhang, G | 1 |
| Wang, Y | 2 |
| Liu, Y | 1 |
| Guo, Q | 1 |
| Farese, JP | 1 |
| Fox, LE | 1 |
| Detrisac, CJ | 1 |
| Van Gilder, JM | 1 |
| Roberts, SL | 1 |
| Baldwin, JM | 1 |
| Tsai, YC | 1 |
| Wu, CT | 1 |
| Hong, RL | 1 |
| Teppo, L | 1 |
| Saxén, E | 1 |
| Tervo, T | 1 |
| Partio, E | 1 |
| von Ronsdorff, H | 1 |
| Salmela, J | 1 |
| Avikainen, V | 1 |
| Isomaki, M | 1 |
| Krees, R | 1 |
4 other studies available for thalidomide and Osteosarcoma
| Article | Year |
|---|---|
Anticancer effect of thalidomide in vitro on human osteosarcoma cells.
Topics: Angiogenesis Inhibitors; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Shape; Drug Screening Ass | 2016 |
Effect of thalidomide on growth and metastasis of canine osteosarcoma cells after xenotransplantation in athymic mice.
Topics: Angiogenesis Inhibitors; Animals; Dimethyl Sulfoxide; Dog Diseases; Dogs; Dose-Response Relationship | 2004 |
Response of refractory osteosarcoma to thalidomide and celecoxib.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Celecoxib; Drug Resistance, Neoplasm | 2005 |
Thalidomide-type malformations and subsequent osteosarcoma.
Topics: Abnormalities, Drug-Induced; Adolescent; Arm; Femoral Neoplasms; Finland; Humans; Leg; Male; Osteosa | 1977 |