thalidomide has been researched along with Obesity in 10 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Apremilast is a novel oral phosphodiesterase-4 inhibitor approved for psoriasis treatment." | 7.88 | Apremilast in psoriasis - a prospective real-world study. ( Herman, R; Monshi, B; Posch, C; Rappersberger, K; Richter, L; Sanlorenzo, M; Vujic, I, 2018) |
| "Apremilast is a novel oral phosphodiesterase-4 inhibitor approved for psoriasis treatment." | 3.88 | Apremilast in psoriasis - a prospective real-world study. ( Herman, R; Monshi, B; Posch, C; Rappersberger, K; Richter, L; Sanlorenzo, M; Vujic, I, 2018) |
| "Lenalidomide (Revlimid; Selleck Chemicals, Houston, TX, USA), an analogue of thalidomide, possesses potent cytokine modulatory capacity through inhibition of cytokines such as tumour necrosis factor (TNF)-α, a cytokine pivotal for the onset and development of complications in obesity and diabetes mellitus." | 3.80 | Tumour necrosis factor-α inhibition with lenalidomide alleviates tissue oxidative injury and apoptosis in ob/ob obese mice. ( Dong, H; Hu, N; Jiang, S; Jones, KR; Kang, YM; Luo, F; Ren, J; Xiong, L; Zhu, X; Zou, Y, 2014) |
| "Lenalidomide is a potent immunomodulatory agent capable of downregulating proinflammatory cytokines such as tumor necrosis factor-α (TNF-α) and upregulating anti-inflammatory cytokines." | 1.38 | Short-term lenalidomide (Revlimid) administration ameliorates cardiomyocyte contractile dysfunction in ob/ob obese mice. ( Dong, M; Hua, Y; Jones, KR; Li, L; Li, Q; Ren, J; Smith, DT; Yuan, M, 2012) |
| "Thalidomide-treated animals received thalidomide i." | 1.36 | The immunosuppressant drug, thalidomide, improves hepatic alterations induced by a high-fat diet in mice. ( Bartchewsky, W; Carvalho, Pde O; Cintra, DE; Compri, CM; Fornari, JV; Gambero, A; Pedrazzoli, J; Pinto, Lde F; Ribeiro, ML; Saad, MJ; Trevisan, M; Velloso, LA, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 7 (70.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kalisch-Smith, JI | 1 |
| Ved, N | 1 |
| Sparrow, DB | 1 |
| Vujic, I | 1 |
| Herman, R | 1 |
| Sanlorenzo, M | 1 |
| Posch, C | 1 |
| Monshi, B | 1 |
| Rappersberger, K | 1 |
| Richter, L | 1 |
| Winiczenko, R | 1 |
| Górnicki, K | 1 |
| Kaleta, A | 1 |
| Janaszek-Mańkowska, M | 1 |
| Khan, ZA | 1 |
| Singh, C | 1 |
| Khan, T | 1 |
| Ganguly, M | 1 |
| Bradsher, C | 1 |
| Goodwin, P | 1 |
| Petty, JT | 1 |
| Sandau, C | 1 |
| Bove, DG | 1 |
| Marsaa, K | 1 |
| Bekkelund, CS | 1 |
| Lindholm, MG | 1 |
| Salazar, J | 1 |
| Bermúdez, V | 1 |
| Olivar, LC | 1 |
| Torres, W | 1 |
| Palmar, J | 1 |
| Añez, R | 1 |
| Ordoñez, MG | 1 |
| Rivas, JR | 1 |
| Martínez, MS | 1 |
| Hernández, JD | 1 |
| Graterol, M | 1 |
| Rojas, J | 1 |
| Mubarak, Z | 1 |
| Humaira, A | 1 |
| Gani, BA | 1 |
| Muchlisin, ZA | 1 |
| Gremillet, C | 1 |
| Jakobsson, JG | 1 |
| Gomila, A | 1 |
| Shaw, E | 1 |
| Carratalà, J | 1 |
| Leibovici, L | 1 |
| Tebé, C | 1 |
| Wiegand, I | 1 |
| Vallejo-Torres, L | 1 |
| Vigo, JM | 1 |
| Morris, S | 1 |
| Stoddart, M | 1 |
| Grier, S | 1 |
| Vank, C | 1 |
| Cuperus, N | 1 |
| Van den Heuvel, L | 1 |
| Eliakim-Raz, N | 1 |
| Vuong, C | 1 |
| MacGowan, A | 1 |
| Addy, I | 1 |
| Pujol, M | 1 |
| Cobb, A | 1 |
| Rieger, E | 1 |
| Bell, J | 1 |
| Mallik, S | 1 |
| Zhao, Z | 1 |
| Szécsényi, Á | 1 |
| Li, G | 1 |
| Gascon, J | 1 |
| Pidko, EA | 1 |
| Zhang, GR | 1 |
| Wolker, T | 1 |
| Sandbeck, DJS | 1 |
| Munoz, M | 1 |
| Mayrhofer, KJJ | 1 |
| Cherevko, S | 1 |
| Etzold, BJM | 1 |
| Lukashuk, L | 1 |
| Yigit, N | 1 |
| Rameshan, R | 1 |
| Kolar, E | 1 |
| Teschner, D | 1 |
| Hävecker, M | 1 |
| Knop-Gericke, A | 1 |
| Schlögl, R | 1 |
| Föttinger, K | 1 |
| Rupprechter, G | 1 |
| Franconieri, F | 1 |
| Deshayes, S | 1 |
| de Boysson, H | 1 |
| Trad, S | 1 |
| Martin Silva, N | 1 |
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| Idorn, M | 1 |
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| Kellermann, L | 1 |
| Halldórsdóttir, HR | 1 |
| Holmen Olofsson, G | 1 |
| Met, Ö | 1 |
| Thor Straten, P | 1 |
| Johnson, LE | 1 |
| Brockstedt, D | 1 |
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| Lauer, P | 1 |
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| McNeel, DG | 1 |
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| Tetzlaff, MT | 1 |
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| Gilbert, M | 1 |
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| Wheeler, DA | 1 |
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| O'Connor, BJ | 1 |
| Fryda, NJ | 1 |
| Ranglack, DH | 1 |
| Yang, Y | 2 |
| Yang, J | 1 |
| Zhang, X | 2 |
| Grün, AL | 1 |
| Emmerling, C | 1 |
| Aumeeruddy-Elalfi, Z | 1 |
| Ismaël, IS | 1 |
| Hosenally, M | 1 |
| Zengin, G | 1 |
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| Lee, MJ | 1 |
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| Kim, SK | 2 |
| Huvinen, E | 1 |
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| Jiang, Y | 2 |
| Zhou, W | 1 |
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| Marques, WL | 1 |
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| Luttik, MAH | 1 |
| van den Broek, M | 1 |
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| Pronk, JT | 1 |
| van Maris, AJA | 1 |
| Mans, R | 1 |
| Gombert, AK | 1 |
| Xu, A | 1 |
| Sun, J | 1 |
| Li, J | 1 |
| Chen, W | 2 |
| Zheng, R | 1 |
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| Ji, L | 1 |
| Shen, WQ | 1 |
| Bao, LP | 1 |
| Hu, SF | 1 |
| Gao, XJ | 1 |
| Xie, YP | 1 |
| Gao, XF | 1 |
| Huang, WH | 1 |
| Lu, X | 1 |
| Gostin, PF | 1 |
| Addison, O | 1 |
| Morrell, AP | 1 |
| Zhang, Y | 2 |
| Cook, AJMC | 1 |
| Liens, A | 1 |
| Stoica, M | 1 |
| Ignatyev, K | 1 |
| Street, SR | 1 |
| Wu, J | 1 |
| Chiu, YL | 1 |
| Davenport, AJ | 1 |
| Qiu, Z | 1 |
| Shu, J | 1 |
| Tang, D | 1 |
| Gao, X | 1 |
| Zhang, J | 3 |
| Huang, K | 1 |
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| Tsai, HJ | 1 |
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| Bayraktar, E | 1 |
| Tas, ST | 1 |
| Gocmen, AY | 1 |
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| Chiappini, A | 1 |
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| Verucchi, R | 1 |
| Ceccato, R | 1 |
| Pasquali, L | 1 |
| List-Kratochvil, EJW | 1 |
| Quaranta, A | 1 |
| Dirè, S | 1 |
| Heo, K | 1 |
| Jo, SH | 1 |
| Shim, J | 1 |
| Kang, DH | 1 |
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| Park, JH | 1 |
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| Kumar, V | 1 |
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| de Fraia Pinto, L | 1 |
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| Trevisan, M | 1 |
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| Velloso, LA | 1 |
| Saad, MJ | 1 |
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| Hua, Y | 1 |
| Dong, M | 1 |
| Li, Q | 1 |
| Smith, DT | 1 |
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| Panigrahy, D | 1 |
| Zhang, CY | 1 |
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1 review available for thalidomide and Obesity
| Article | Year |
|---|---|
Environmental Risk Factors for Congenital Heart Disease.
Topics: Alcohol Drinking; Animals; Diabetes Mellitus; Environmental Exposure; Gene-Environment Interaction; | 2020 |
1 trial available for thalidomide and Obesity
| Article | Year |
|---|---|
Topics: Activities of Daily Living; Acute Disease; Adalimumab; Adaptation, Physiological; Adenosine Triphosp | 2018 |
8 other studies available for thalidomide and Obesity
| Article | Year |
|---|---|
Apremilast in psoriasis - a prospective real-world study.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Body Weight; Diarrhea; Drug Substi | 2018 |
More drug studies need to include pregnant women, says bulletin.
Topics: Anticonvulsants; Clinical Trials as Topic; Drug Industry; Female; Humans; Hypnotics and Sedatives; M | 2013 |
Tumour necrosis factor-α inhibition with lenalidomide alleviates tissue oxidative injury and apoptosis in ob/ob obese mice.
Topics: Animals; Apoptosis; Blood Glucose; Gene Expression Regulation; Glucose; Immunologic Factors; Intesti | 2014 |
Thalidomide controls adipose tissue inflammation associated with high-fat diet-induced obesity in mice.
Topics: 3T3-L1 Cells; Adipogenesis; Adipokines; Adipose Tissue; Adiposity; Animals; Anti-Inflammatory Agents | 2015 |
The immunosuppressant drug, thalidomide, improves hepatic alterations induced by a high-fat diet in mice.
Topics: Animals; Biopsy, Needle; Blood Glucose; Diet; Dietary Fats; Disease Models, Animal; Fatty Liver; Imm | 2010 |
Short-term lenalidomide (Revlimid) administration ameliorates cardiomyocyte contractile dysfunction in ob/ob obese mice.
Topics: Absorptiometry, Photon; Animals; Blotting, Western; Caspases, Effector; Cells, Cultured; Endoplasmic | 2012 |
Adipose tissue mass can be regulated through the vasculature.
Topics: Adipose Tissue; Angiogenesis Inhibitors; Angiostatins; Animals; Antineoplastic Agents; Biphenyl Comp | 2002 |
Hypothyroidism caused by thalidomide.
Topics: Adult; Angiogenesis Inhibitors; Female; Humans; Hypothyroidism; Multiple Myeloma; Obesity; Thalidomi | 2006 |