thalidomide has been researched along with Neuralgia in 14 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The patients received PTX at the initiating dosage until complete clinical cure." | 6.71 | [Pentoxifylline in the treatment of erythema nodosum leprosum: results of an open study]. ( Achirafi, A; de Carsalade, GY; Flageul, B, 2003) |
| " The patients received PTX at the initiating dosage until complete clinical cure." | 2.71 | [Pentoxifylline in the treatment of erythema nodosum leprosum: results of an open study]. ( Achirafi, A; de Carsalade, GY; Flageul, B, 2003) |
| "Thirty-three patients (26%) reported neuropathic pain." | 1.91 | Age-related changes in patients with upper limb thalidomide embryopathy in the United Kingdom. ( Brennan, S; Hooper, G; Lam, W; Markiewicz, M; Stirling, P, 2023) |
| "The management of patients with neuropathic pain is challenging." | 1.42 | Prolonged Suppression of Neuropathic Pain by Sequential Delivery of Lidocaine and Thalidomide Drugs Using PEGylated Graphene Oxide. ( Gu, K; Guan, J; Ma, P; Ma, X; Qi, Y; Song, T; Wang, C; Wang, H; Wang, W; Ya, J; Yan, R; Yang, L; Yang, Y; Zhao, J, 2015) |
| "Thermal hyperalgesia and mechanical allodynia were measured using planter test and dynamic aesthesiometer (Ugo-Basile, Italy), respectively." | 1.38 | Possible mechanism of protective effect of thalidomide in STZ-induced-neuropathic pain behavior in rats. ( Sharma, PL; Taliyan, R, 2012) |
| "Thalidomide was the only treatment that attenuated these increases." | 1.38 | The thalidomide analgesic effect is associated with differential TNF-α receptor expression in the dorsal horn of the spinal cord as studied in a rat model of neuropathic pain. ( Andrade, P; Buurman, WA; Daemen, MA; Del Rosario, JS; Hoogland, G; Steinbusch, HW; Visser-Vandewalle, V, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 7 (50.00) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Markiewicz, M | 1 |
| Stirling, P | 1 |
| Brennan, S | 1 |
| Hooper, G | 1 |
| Lam, W | 1 |
| Groenen, PS | 1 |
| van Helmond, N | 1 |
| Chapman, KB | 1 |
| Chu, SH | 1 |
| Lee, YJ | 1 |
| Lee, ES | 1 |
| Geng, Y | 1 |
| Wang, XS | 1 |
| Cleeland, CS | 1 |
| Song, T | 1 |
| Gu, K | 1 |
| Wang, W | 1 |
| Wang, H | 1 |
| Yang, Y | 1 |
| Yang, L | 1 |
| Ma, P | 1 |
| Ma, X | 1 |
| Zhao, J | 1 |
| Yan, R | 1 |
| Guan, J | 1 |
| Wang, C | 1 |
| Qi, Y | 1 |
| Ya, J | 1 |
| Manning, DC | 1 |
| Gimbel, J | 1 |
| Wertz, R | 1 |
| Rauck, R | 1 |
| Cooper, A | 1 |
| Zeldis, JB | 1 |
| Levinsky, DM | 1 |
| Farquhar-Smith, P | 1 |
| Taliyan, R | 1 |
| Sharma, PL | 1 |
| Andrade, P | 1 |
| Visser-Vandewalle, V | 1 |
| Del Rosario, JS | 1 |
| Daemen, MA | 1 |
| Buurman, WA | 1 |
| Steinbusch, HW | 1 |
| Hoogland, G | 1 |
| de Carsalade, GY | 1 |
| Achirafi, A | 1 |
| Flageul, B | 1 |
| Mulleman, D | 1 |
| Mammou, S | 1 |
| Griffoul, I | 1 |
| Watier, H | 1 |
| Goupille, P | 1 |
| Xu, JT | 2 |
| Xin, WJ | 2 |
| Zang, Y | 2 |
| Wu, CY | 2 |
| Liu, XG | 2 |
| Wei, XH | 1 |
| Ge, YX | 1 |
| Liu, YL | 1 |
| Zhang, T | 1 |
| Li, YY | 1 |
| Sommer, C | 1 |
| Marziniak, M | 1 |
| Myers, RR | 1 |
| Belda, W | 1 |
| Manzoli, S | 1 |
| Jordy, CF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Painful Lumbar Radiculopathy[NCT00120120] | Phase 2/Phase 3 | 181 participants (Actual) | Interventional | 2005-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for thalidomide and Neuralgia
| Article | Year |
|---|---|
Current use of drugs affecting the central nervous system for chemotherapy-induced peripheral neuropathy in cancer patients: a systematic review.
Topics: Amitriptyline; Anticonvulsants; Antidepressive Agents; Antineoplastic Agents; Boronic Acids; Bortezo | 2015 |
Chemotherapy-induced neuropathic pain.
Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Humans; Neuralgia; Pyrazines; Thalidomide | 2011 |
Pathophysiology of disk-related low back pain and sciatica. II. Evidence supporting treatment with TNF-alpha antagonists.
Topics: Animals; Antibodies, Monoclonal; Doxycycline; Humans; Infliximab; Low Back Pain; Neuralgia; Pentoxif | 2006 |
2 trials available for thalidomide and Neuralgia
| Article | Year |
|---|---|
A Phase II Randomized, Double-Blind, Placebo-Controlled Safety and Efficacy Study of Lenalidomide in Lumbar Radicular Pain with a Long-Term Open-Label Extension Phase.
Topics: Adult; Aged; Double-Blind Method; Female; Humans; Immunologic Factors; Lenalidomide; Lumbosacral Reg | 2017 |
[Pentoxifylline in the treatment of erythema nodosum leprosum: results of an open study].
Topics: Adolescent; Adult; Erythema Nodosum; Female; Follow-Up Studies; Glucocorticoids; Humans; Immunosuppr | 2003 |
9 other studies available for thalidomide and Neuralgia
| Article | Year |
|---|---|
Age-related changes in patients with upper limb thalidomide embryopathy in the United Kingdom.
Topics: Abnormalities, Multiple; Female; Fetal Diseases; Humans; Neuralgia; Quality of Life; Thalidomide; Up | 2023 |
Chemotherapy-Induced Peripheral Neuropathy Treated with Dorsal Root Ganglion Stimulation.
Topics: Electric Stimulation Therapy; Female; Ganglia, Spinal; Humans; Immunosuppressive Agents; Lupus Eryth | 2019 |
Prolonged Suppression of Neuropathic Pain by Sequential Delivery of Lidocaine and Thalidomide Drugs Using PEGylated Graphene Oxide.
Topics: Anesthetics, Local; Animals; Cells, Cultured; Cytokines; Delayed-Action Preparations; Graphite; Huma | 2015 |
Possible mechanism of protective effect of thalidomide in STZ-induced-neuropathic pain behavior in rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Blood Glucose; Diabetes Mellitus, Experimental; Diabe | 2012 |
The thalidomide analgesic effect is associated with differential TNF-α receptor expression in the dorsal horn of the spinal cord as studied in a rat model of neuropathic pain.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Hyperalgesia; Male; Neuralgia; Pain Measurement; | 2012 |
The role of tumor necrosis factor-alpha in the neuropathic pain induced by Lumbar 5 ventral root transection in rat.
Topics: Animals; Anterior Horn Cells; Behavior, Animal; Foot; Ganglia, Spinal; Hindlimb; Hot Temperature; Hy | 2006 |
p38 activation in uninjured primary afferent neurons and in spinal microglia contributes to the development of neuropathic pain induced by selective motor fiber injury.
Topics: Animals; Denervation; Enzyme Activation; Enzyme Inhibitors; Ganglia, Spinal; Hyperalgesia; Hypesthes | 2007 |
The effect of thalidomide treatment on vascular pathology and hyperalgesia caused by chronic constriction injury of rat nerve.
Topics: Analysis of Variance; Animals; Chronic Disease; Constriction; Disease Models, Animal; Female; Hypera | 1998 |
[Thalidomide in the control of pain in leprotic neuritis].
Topics: Female; Humans; Leprosy; Male; Neuralgia; Neuritis; Pain; Thalidomide | 1966 |