thalidomide has been researched along with Nephritis, Interstitial in 3 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Nephritis, Interstitial: Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES and/or surrounding interstitium. For primary inflammation of glomerular interstitium, see GLOMERULONEPHRITIS. Infiltration of the inflammatory cells into the interstitial compartment results in EDEMA, increased spaces between the tubules, and tubular renal dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We report a case of a severe 'drug reaction with eosinophilia and systemic symptoms' syndrome associated with acute interstitial nephritis in a patient with multiple myeloma likely related to the administration of lenalidomide." | 7.80 | A case of DRESS (drug reaction with eosinophilia and systemic symptoms) with acute interstitial nephritis secondary to lenalidomide. ( Guron, G; Layne, T; Shaaban, H, 2014) |
| " We report a case of a severe 'drug reaction with eosinophilia and systemic symptoms' syndrome associated with acute interstitial nephritis in a patient with multiple myeloma likely related to the administration of lenalidomide." | 3.80 | A case of DRESS (drug reaction with eosinophilia and systemic symptoms) with acute interstitial nephritis secondary to lenalidomide. ( Guron, G; Layne, T; Shaaban, H, 2014) |
| " The present review examines the drug's pharmacokinetics, discusses the main adverse renal effects that are associated with lenalidomide treatment, and makes recommendations for dosage adjustment in patients with underlying renal impairment." | 2.53 | [Lenalidomide nephrotoxicity]. ( Izzedine, H; Kheder El-Fekih, R, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shaaban, H | 1 |
| Layne, T | 1 |
| Guron, G | 1 |
| Kheder El-Fekih, R | 1 |
| Izzedine, H | 1 |
| Lipson, EJ | 1 |
| Huff, CA | 1 |
| Holanda, DG | 1 |
| McDevitt, MA | 1 |
| Fine, DM | 1 |
1 review available for thalidomide and Nephritis, Interstitial
| Article | Year |
|---|---|
[Lenalidomide nephrotoxicity].
Topics: Graft vs Host Disease; Humans; Immunologic Factors; Kidney; Kidney Tubules; Lenalidomide; Necrosis; | 2016 |
2 other studies available for thalidomide and Nephritis, Interstitial
| Article | Year |
|---|---|
A case of DRESS (drug reaction with eosinophilia and systemic symptoms) with acute interstitial nephritis secondary to lenalidomide.
Topics: Acute Kidney Injury; Adrenal Cortex Hormones; Aged; Drug Hypersensitivity Syndrome; Female; Humans; | 2014 |
Lenalidomide-induced acute interstitial nephritis.
Topics: Acute Disease; Antineoplastic Agents; Female; Humans; Lenalidomide; Middle Aged; Multiple Myeloma; N | 2010 |