thalidomide has been researched along with Neoplasms, Germ Cell and Embryonal in 5 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Neoplasms, Germ Cell and Embryonal: Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lenalidomide was well tolerated but did not show efficacy in heavily pretreated patients with cisplatin-refractory and multiply relapsed germ cell tumors." | 2.75 | Lenalidomide in patients with cisplatin-refractory and multiply relapsed germ cell tumors. ( Bokemeyer, C; Honecker, F; Oechsle, K, 2010) |
| "Germ cell tumors are the most common malignancies in men under 50 years and also the most common cause of death from solid tumors in this age group." | 2.45 | Germ cell tumors of the gonads: a selective review emphasizing problems in drug resistance and current therapy options. ( Albers, P; Christoph, F; Hinz, S; Hoepfner, M; Jung, K; Kempkensteffen, C; Krause, H; Lein, M; Miller, K; Schostak, M; Schrader, M; Stephan, C; Weikert, S, 2009) |
| "Mediastinal nonseminomatous germ cell tumor (MNSGCT)-associated histiocytic proliferations are rare and rapidly fatal disorders." | 1.43 | Mediastinal Germ Cell Tumor-associated Histiocytic Proliferations Treated With Thalidomide Plus Chemotherapy Followed by Alemtuzumab-containing Reduced Intensity Allogeneic Peripheral Blood Stem Cell Transplantation: A Case Report. ( Chen, RL; Chen, WT; Fang, LH; Lee, PI; Shih, LS, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Prince, SK | 1 |
| Forgeson, G | 1 |
| Fang, LH | 1 |
| Shih, LS | 1 |
| Lee, PI | 1 |
| Chen, WT | 1 |
| Chen, RL | 1 |
| Schrader, M | 1 |
| Kempkensteffen, C | 1 |
| Christoph, F | 1 |
| Hinz, S | 1 |
| Weikert, S | 1 |
| Lein, M | 1 |
| Krause, H | 1 |
| Stephan, C | 1 |
| Jung, K | 1 |
| Hoepfner, M | 1 |
| Albers, P | 1 |
| Miller, K | 1 |
| Schostak, M | 1 |
| Oechsle, K | 1 |
| Bokemeyer, C | 1 |
| Honecker, F | 1 |
| Rick, O | 1 |
| Braun, T | 1 |
| Siegert, W | 1 |
| Beyer, J | 1 |
1 review available for thalidomide and Neoplasms, Germ Cell and Embryonal
| Article | Year |
|---|---|
Germ cell tumors of the gonads: a selective review emphasizing problems in drug resistance and current therapy options.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Cell | 2009 |
1 trial available for thalidomide and Neoplasms, Germ Cell and Embryonal
| Article | Year |
|---|---|
Lenalidomide in patients with cisplatin-refractory and multiply relapsed germ cell tumors.
Topics: Adult; Antineoplastic Agents; Cisplatin; Compassionate Use Trials; Drug Resistance, Neoplasm; Humans | 2010 |
3 other studies available for thalidomide and Neoplasms, Germ Cell and Embryonal
| Article | Year |
|---|---|
Bleeding from gastrointestinal tract recurrence of non-seminomatous germ cell tumour testis, showing temporary response to gemcitabine and oxaliplatin chemotherapy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Gastrointestinal Hemorrhage; G | 2013 |
Mediastinal Germ Cell Tumor-associated Histiocytic Proliferations Treated With Thalidomide Plus Chemotherapy Followed by Alemtuzumab-containing Reduced Intensity Allogeneic Peripheral Blood Stem Cell Transplantation: A Case Report.
Topics: Alemtuzumab; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Fatal Outcome; Histiocytic Sa | 2016 |
Activity of thalidomide in patients with platinum-refractory germ-cell tumours.
Topics: Adult; Antineoplastic Agents; Drug Resistance, Neoplasm; Gonadal Disorders; Humans; Mediastinal Neop | 2006 |