thalidomide has been researched along with Neglected Diseases in 1 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Neglected Diseases: Diseases that are underfunded and have low name recognition but are major burdens in less developed countries. The World Health Organization has designated six tropical infectious diseases as being neglected in industrialized countries that are endemic in many developing countries (HELMINTHIASIS; LEPROSY; LYMPHATIC FILARIASIS; ONCHOCERCIASIS; SCHISTOSOMIASIS; and TRACHOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thalidomide has a rapid action but its use is limited due the teratogenicity and neurotoxicity." | 2.58 | Erythema Nodosum Leprosum: Update and challenges on the treatment of a neglected condition. ( Costa, PDSS; Daxbacher, ELR; Fraga, LR; Kowalski, TW; Schuler-Faccini, L; Vianna, FSL, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Costa, PDSS | 1 |
| Fraga, LR | 1 |
| Kowalski, TW | 1 |
| Daxbacher, ELR | 1 |
| Schuler-Faccini, L | 1 |
| Vianna, FSL | 1 |
1 review available for thalidomide and Neglected Diseases
| Article | Year |
|---|---|
Erythema Nodosum Leprosum: Update and challenges on the treatment of a neglected condition.
Topics: Anti-Inflammatory Agents; Erythema Nodosum; Glucocorticoids; Humans; Inflammation; Leprostatic Agent | 2018 |