Compounds > thalidomide
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thalidomide and Microphthalmia

thalidomide has been researched along with Microphthalmia in 8 studies

Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.

Research Excerpts

ExcerptRelevanceReference
"Present knowledge of chromosomal aberrations associated with microphthalmia is surveyed, and some of the syndromes and phenocopies in the mentally retarded in which microphthalmia may be found are reviewed."2.35The heterogeneity of microphthalmia in the mentally retarded. ( Warburg, M, 1971)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19907 (87.50)18.7374
1990's1 (12.50)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
PAPST, W1
OTTO, J1
HONEGGER, H1
PAPE, R1
Strömland, K1
Miller, MT1
Smithells, RW1
Warburg, M1
Zetterström, B1
Cullen, JF1

Reviews

1 review available for thalidomide and Microphthalmia

ArticleYear
The heterogeneity of microphthalmia in the mentally retarded.
    Birth defects original article series, 1971, Volume: 7, Issue:3

    Topics: Abnormalities, Multiple; Abortifacient Agents; Adolescent; Adult; Brain Injuries; Child, Preschool;

1971

Other Studies

7 other studies available for thalidomide and Microphthalmia

ArticleYear
[THALIDOMIDE AND CONGENITAL ABNORMALITIES OF THE EYE].
    Bericht uber die Zusammenkunft. Deutsche Ophthalmologische Gesellschaft, 1964, Volume: 65

    Topics: Abnormalities, Drug-Induced; Anophthalmos; Child; Eye Diseases; Infant; Learning; Microphthalmos; Op

1964
[CONTERGAN INJURY WITH EYE INVOLVEMENT].
    Bericht uber die Zusammenkunft. Deutsche Ophthalmologische Gesellschaft, 1964, Volume: 65

    Topics: Abnormalities, Drug-Induced; Child; Eye Diseases; Female; Learning; Microphthalmos; Pregnancy; Prena

1964
[THALIDOMIDE AND CONGENITAL ABNORMALITIES OF THE EYE].
    Bericht uber die Zusammenkunft. Deutsche Ophthalmologische Gesellschaft, 1964, Volume: 65

    Topics: Abnormalities, Drug-Induced; Child; Eye Diseases; Female; Learning; Microphthalmos; Pregnancy; Prena

1964
Refractive evaluation in thalidomide embryopathy.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1992, Volume: 230, Issue:2

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Cornea; Eye Abnormalities; Female; Huma

1992
Defects and disabilities of thalidomide children.
    British medical journal, 1973, Feb-03, Volume: 1, Issue:5848

    Topics: Abnormalities, Drug-Induced; Arm; Child; Coloboma; Ear; Ectromelia; Eye Abnormalities; Heart Defects

1973
Ocular malformations caused by thalidomide.
    Acta ophthalmologica, 1966, Volume: 44, Issue:3

    Topics: Child; Child, Preschool; Eye Abnormalities; Eye Diseases; Female; Humans; Male; Microphthalmos; Nyst

1966
Teratogenic agents and thalidomide.
    Transactions of the ophthalmological societies of the United Kingdom, 1966, Volume: 86

    Topics: Abnormalities, Drug-Induced; Coloboma; Eye Abnormalities; Female; Humans; Infant, Newborn; Male; Mic

1966