thalidomide has been researched along with Meningitis, Tuberculous in 15 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thalidomide was developed nearly seventy years ago and has been a highly controversial drug." | 2.72 | The use of thalidomide to treat children with tuberculosis meningitis: A review. ( Marceline van Furth, A; Schoeman, JF; Seddon, JA; Solomons, RS; van der Kuip, M; van Toorn, R; Zaharie, SD, 2021) |
| "Childhood tuberculous meningitis is associated with serious long-term sequelae, including mental retardation, behavior disturbances, and motor handicap." | 2.71 | Adjunctive thalidomide therapy for childhood tuberculous meningitis: results of a randomized study. ( Hanekom, WA; Haslett, PA; Kaplan, G; Schoeman, JF; Springer, P; Swanevelder, S; van Rensburg, AJ, 2004) |
| "Thalidomide was administered via nasogastric tube in a dosage of 6 mg/kg/day, 12 mg/kg/day, or 24 mg/kg/day." | 2.69 | Adjunctive thalidomide therapy of childhood tuberculous meningitis: possible anti-inflammatory role. ( Bekker, LG; Donald, PR; Hanekom, WA; Haslett, PA; Kaplan, G; Ravenscroft, A; Schoeman, JF; Springer, P; van Rensburg, AJ, 2000) |
| "Tuberculous meningitis is a highly morbid, often fatal disease." | 1.48 | Intracranial tuberculous mass lesions treated with thalidomide in an immunocompetent child from a low tuberculosis endemic country: A case report. ( Ajassa, C; Caraffa, E; Ciardi, MR; Lichtner, M; Massetti, AP; Mastroianni, CM; Russo, G; Vita, S; Vullo, V, 2018) |
| "Thalidomide was introduced as an immunomodulatory adjunct and subsequently the patient made a complete neurological recovery." | 1.32 | The use of thalidomide in the treatment of intracranial tuberculomas in adults: two case reports. ( Carmichael, A; Lever, AM; Mendelson, M; Meyer, P; Roberts, MT, 2003) |
| "When thalidomide treatment was combined with antibiotics, there was a marked reduction in TNF-alpha levels, leukocytosis, and brain pathology." | 1.30 | A combination of thalidomide plus antibiotics protects rabbits from mycobacterial meningitis-associated death. ( Freedman, VH; Kaplan, G; Sokol, K; Tsenova, L, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 6 (40.00) | 29.6817 |
| 2010's | 4 (26.67) | 24.3611 |
| 2020's | 3 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| van Toorn, R | 4 |
| Zaharie, SD | 1 |
| Seddon, JA | 2 |
| van der Kuip, M | 1 |
| Marceline van Furth, A | 1 |
| Schoeman, JF | 7 |
| Solomons, RS | 2 |
| Kumar, R | 1 |
| Kolloli, A | 1 |
| Singh, P | 1 |
| Vinnard, C | 1 |
| Kaplan, G | 5 |
| Subbian, S | 1 |
| Liu, P | 1 |
| Pei, N | 1 |
| Liu, X | 1 |
| Huang, W | 1 |
| Lu, S | 1 |
| Caraffa, E | 1 |
| Russo, G | 1 |
| Vita, S | 1 |
| Lichtner, M | 1 |
| Massetti, AP | 1 |
| Mastroianni, CM | 1 |
| Vullo, V | 1 |
| Ciardi, MR | 1 |
| Ajassa, C | 1 |
| du Plessis, AM | 1 |
| Schaaf, HS | 1 |
| Buys, H | 1 |
| Hewlett, RH | 1 |
| Stefan, DC | 2 |
| Andronikou, S | 2 |
| Freeman, N | 2 |
| Schoeman, J | 1 |
| Roberts, MT | 1 |
| Mendelson, M | 1 |
| Meyer, P | 1 |
| Carmichael, A | 1 |
| Lever, AM | 1 |
| Springer, P | 2 |
| van Rensburg, AJ | 2 |
| Swanevelder, S | 1 |
| Hanekom, WA | 2 |
| Haslett, PA | 2 |
| Tsenova, L | 2 |
| Sokol, K | 1 |
| Freedman, VH | 2 |
| Ravenscroft, A | 1 |
| Donald, PR | 1 |
| Bekker, LG | 1 |
| Mangaliso, B | 1 |
| Muller, G | 1 |
| Chen, Y | 1 |
| Stirling, D | 1 |
| Kewitz, H | 1 |
2 reviews available for thalidomide and Meningitis, Tuberculous
| Article | Year |
|---|---|
The use of thalidomide to treat children with tuberculosis meningitis: A review.
Topics: Antitubercular Agents; Child; Cytokines; Humans; Thalidomide; Tuberculosis, Meningeal; Tumor Necrosi | 2021 |
Thalidomide and Phosphodiesterase 4 Inhibitors as Host Directed Therapeutics for Tuberculous Meningitis: Insights From the Rabbit Model.
Topics: Animals; Antitubercular Agents; Blood-Brain Barrier; Brain; Cytokines; Disease Models, Animal; Human | 2019 |
3 trials available for thalidomide and Meningitis, Tuberculous
| Article | Year |
|---|---|
Adjunctive thalidomide therapy for childhood tuberculous meningitis: results of a randomized study.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antitubercular Agents; Chemotherapy, Adjuvant; Ch | 2004 |
Adjunctive thalidomide therapy of childhood tuberculous meningitis: possible anti-inflammatory role.
Topics: Adjuvants, Immunologic; Antitubercular Agents; Biomarkers; Brain; Child; Child, Preschool; Clinical | 2000 |
Thalidomide therapy in childhood tuberculous menigitis.
Topics: Child; Double-Blind Method; Fatal Outcome; Humans; Immunosuppressive Agents; Motor Skills Disorders; | 2000 |
10 other studies available for thalidomide and Meningitis, Tuberculous
| Article | Year |
|---|---|
Thalidomide in the treatment of human immunodeficiency virus-negative tuberculous meningitis: A case report.
Topics: Adrenal Cortex Hormones; Adult; Antitubercular Agents; Asian People; Brain; Drug Therapy, Combinatio | 2020 |
Thalidomide Use for Complicated Central Nervous System Tuberculosis in Children: Insights From an Observational Cohort.
Topics: Adult; Antitubercular Agents; Child; Humans; Retrospective Studies; Thalidomide; Tuberculosis, Centr | 2021 |
Intracranial tuberculous mass lesions treated with thalidomide in an immunocompetent child from a low tuberculosis endemic country: A case report.
Topics: Antitubercular Agents; Brain; Cerebrospinal Fluid; Child; Female; Glucocorticoids; Humans; Hydroceph | 2018 |
Clinicoradiologic response of neurologic tuberculous mass lesions in children treated with thalidomide.
Topics: Adolescent; Antitubercular Agents; Child; Child, Preschool; Female; Head; Humans; Immunosuppressive | 2015 |
Recovery of vision after adjuvant thalidomide in a child with tuberculous meningitis and acute lymphoblastic leukemia.
Topics: Adrenal Cortex Hormones; Antineoplastic Combined Chemotherapy Protocols; Blindness; Brain; Chemother | 2009 |
Tuberculous meningitis-related optic neuritis: recovery of vision with thalidomide in 4 consecutive cases.
Topics: Antitubercular Agents; Brain; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Ma | 2010 |
The use of thalidomide in the treatment of intracranial tuberculomas in adults: two case reports.
Topics: Adult; Female; Humans; Immunosuppressive Agents; Thalidomide; Treatment Outcome; Tuberculoma, Intrac | 2003 |
A combination of thalidomide plus antibiotics protects rabbits from mycobacterial meningitis-associated death.
Topics: Animals; Antibiotics, Antitubercular; Disease Models, Animal; Drug Therapy, Combination; Immunosuppr | 1998 |
Use of IMiD3, a thalidomide analog, as an adjunct to therapy for experimental tuberculous meningitis.
Topics: Animals; Antitubercular Agents; Brain; Central Nervous System; Female; Immunosuppressive Agents; Len | 2002 |
[Drugs as cause of diseases].
Topics: Abnormalities, Drug-Induced; Berlin; Contraceptives, Oral; Cortisone; Drug-Related Side Effects and | 1974 |