thalidomide has been researched along with Meningitis, Pneumococcal in 1 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Meningitis, Pneumococcal: An acute purulent infection of the meninges and subarachnoid space caused by Streptococcus pneumoniae, most prevalent in children and adults over the age of 60. This illness may be associated with OTITIS MEDIA; MASTOIDITIS; SINUSITIS; RESPIRATORY TRACT INFECTIONS; sickle cell disease (ANEMIA, SICKLE CELL); skull fractures; and other disorders. Clinical manifestations include FEVER; HEADACHE; neck stiffness; and somnolence followed by SEIZURES; focal neurologic deficits (notably DEAFNESS); and COMA. (From Miller et al., Merritt's Textbook of Neurology, 9th ed, p111)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thalidomide treatment reduces TNF-alpha production in both experimental systems, but has a greater effect on the more indolent gram positive inflammatory response in which peak TNF-alpha levels in the CSF are reduced by > 50%." | 1.29 | Effect of thalidomide on the inflammatory response in cerebrospinal fluid in experimental bacterial meningitis. ( Burroughs, MH; Kaplan, G; Ossig, J; Sokol, K; Tsenova-Berkova, L; Tuomanen, E, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Burroughs, MH | 1 |
| Tsenova-Berkova, L | 1 |
| Sokol, K | 1 |
| Ossig, J | 1 |
| Tuomanen, E | 1 |
| Kaplan, G | 1 |
1 other study available for thalidomide and Meningitis, Pneumococcal
| Article | Year |
|---|---|
Effect of thalidomide on the inflammatory response in cerebrospinal fluid in experimental bacterial meningitis.
Topics: Animals; Cerebrospinal Fluid Proteins; Disease Models, Animal; Humans; Inflammation; Interleukin-1; | 1995 |