thalidomide has been researched along with Meningitis, Cryptococcal in 4 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Meningitis, Cryptococcal: Meningeal inflammation produced by CRYPTOCOCCUS NEOFORMANS, an encapsulated yeast that tends to infect individuals with ACQUIRED IMMUNODEFICIENCY SYNDROME and other immunocompromised states. The organism enters the body through the respiratory tract, but symptomatic infections are usually limited to the lungs and nervous system. The organism may also produce parenchymal brain lesions (torulomas). Clinically, the course is subacute and may feature HEADACHE; NAUSEA; PHOTOPHOBIA; focal neurologic deficits; SEIZURES; cranial neuropathies; and HYDROCEPHALUS. (From Adams et al., Principles of Neurology, 6th ed, pp721-2)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Management of relapsing or refractory immune reconstitution inflammatory syndromes (IRISs) despite corticosteroid therapy is yet to be defined." | 1.38 | Thalidomide for steroid-dependent immune reconstitution inflammatory syndromes during AIDS. ( Brunel, AS; Le Moing, V; Lortholary, O; Makinson, A; Montes, B; Reynes, J; Rubbo, PA; Tuaillon, E, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Qin, BE | 1 |
| Yuan, D | 1 |
| Xu, XF | 1 |
| Su, Z | 1 |
| Gu, M | 1 |
| Dai, K | 1 |
| Peng, FH | 1 |
| Jiang, Y | 1 |
| Kwon, HY | 1 |
| Han, YJ | 1 |
| Im, JH | 1 |
| Baek, JH | 1 |
| Lee, JS | 1 |
| Balasko, A | 1 |
| Keynan, Y | 1 |
| Brunel, AS | 1 |
| Reynes, J | 1 |
| Tuaillon, E | 1 |
| Rubbo, PA | 1 |
| Lortholary, O | 1 |
| Montes, B | 1 |
| Le Moing, V | 1 |
| Makinson, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Efficacy and Safety of Thalidomide in the Adjuvant Treatment of Moderate New Coronavirus (COVID-19) Pneumonia: a Prospective, Multicenter, Randomized, Double-blind, Placebo, Parallel Controlled Clinical Study[NCT04273529] | Phase 2 | 100 participants (Anticipated) | Interventional | 2020-02-20 | Not yet recruiting | ||
| The Efficacy and Safety of Thalidomide Combined With Low-dose Hormones in the Treatment of Severe New Coronavirus (COVID-19) Pneumonia: a Prospective, Multicenter, Randomized, Double-blind, Placebo, Parallel Controlled Clinical Study[NCT04273581] | Phase 2 | 40 participants (Anticipated) | Interventional | 2020-02-18 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for thalidomide and Meningitis, Cryptococcal
| Article | Year |
|---|---|
Shedding light on IRIS: from Pathophysiology to Treatment of Cryptococcal Meningitis and Immune Reconstitution Inflammatory Syndrome in HIV-Infected Individuals.
Topics: Adrenal Cortex Hormones; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Clinical Tri | 2019 |
3 other studies available for thalidomide and Meningitis, Cryptococcal
| Article | Year |
|---|---|
Neurological worsening during treatment of HIV-negative cryptococcal meningitis in a patient with Evans syndrome.
Topics: Adrenal Cortex Hormones; Antifungal Agents; Female; HIV Infections; Humans; Immune Reconstitution In | 2023 |
Two cases of immune reconstitution inflammatory syndrome in HIV patients treated with thalidomide.
Topics: Adult; AIDS-Related Opportunistic Infections; Antiretroviral Therapy, Highly Active; Brain Edema; Do | 2019 |
Two cases of immune reconstitution inflammatory syndrome in HIV patients treated with thalidomide.
Topics: Adult; AIDS-Related Opportunistic Infections; Antiretroviral Therapy, Highly Active; Brain Edema; Do | 2019 |
Two cases of immune reconstitution inflammatory syndrome in HIV patients treated with thalidomide.
Topics: Adult; AIDS-Related Opportunistic Infections; Antiretroviral Therapy, Highly Active; Brain Edema; Do | 2019 |
Two cases of immune reconstitution inflammatory syndrome in HIV patients treated with thalidomide.
Topics: Adult; AIDS-Related Opportunistic Infections; Antiretroviral Therapy, Highly Active; Brain Edema; Do | 2019 |
Thalidomide for steroid-dependent immune reconstitution inflammatory syndromes during AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Antiretroviral The | 2012 |