thalidomide has been researched along with Malaria in 3 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Indoloquinoline (IQ) is an important class of naturally occurring antimalarial alkaloids, mainly represented by cryptolepine, isocryptolepine, and neocryptolepine." | 5.22 | Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids. ( Bharate, SB; Mudududdla, R; Nuthakki, VK, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Nuthakki, VK | 1 |
| Mudududdla, R | 1 |
| Bharate, SB | 1 |
| Muniz-Junqueira, MI | 1 |
| Silva, FO | 1 |
| de Paula-Júnior, MR | 1 |
| Tosta, CE | 1 |
| Heischkeil, R | 1 |
1 review available for thalidomide and Malaria
| Article | Year |
|---|---|
Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids.
Topics: Alkaloids; Antimalarials; Antineoplastic Agents; Cell Proliferation; Indoles; Malaria; Molecular Str | 2022 |
2 other studies available for thalidomide and Malaria
| Article | Year |
|---|---|
Thalidomide influences the function of macrophages and increases the survival of Plasmodium berghei-infected CBA mice.
Topics: Animals; Hydrogen Peroxide; Immunosuppressive Agents; Macrophages, Peritoneal; Malaria; Male; Mice; | 2005 |
[Antimetabolites of folic acid metabolism with chemotherapeutic activity against rodent malaria (Plasmodium vinckei)].
Topics: Aminopterin; Animals; Cycloheximide; Female; Folic Acid; Folic Acid Antagonists; Hydantoins; Malaria | 1973 |