thalidomide has been researched along with MS (Multiple Sclerosis) in 5 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Contino-Pépin, C | 3 |
| Parat, A | 2 |
| Périno, S | 1 |
| Lenoir, C | 1 |
| Vidal, M | 1 |
| Galons, H | 1 |
| Karlik, S | 1 |
| Pucci, B | 2 |
| Patinote, C | 2 |
| Roscoe, WA | 2 |
| Karlik, SJ | 2 |
| Owens, T | 1 |
| Sastry, PS | 1 |
2 reviews available for thalidomide and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
Targeting vascular changes in lesions in multiple sclerosis and experimental autoimmune encephalomyelitis.
Topics: Angiogenesis Inhibitors; Animals; Drug Delivery Systems; Encephalomyelitis, Autoimmune, Experimental | 2012 |
Identification of new therapeutic targets for prevention of CNS inflammation.
Topics: Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antigens, CD; B7-2 Antigen; Cytokines; En | 2002 |
3 other studies available for thalidomide and MS (Multiple Sclerosis)
| Article | Year |
|---|---|
Preliminary biological evaluations of new thalidomide analogues for multiple sclerosis application.
Topics: Angiogenesis Inhibitors; Animals; Cell Line; Cell Proliferation; Chemistry, Pharmaceutical; Drug Des | 2009 |
Thalidomide derivatives for the treatment of neuroinflammation.
Topics: Administration, Oral; Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; | 2010 |
Inhibition of TNF-alpha synthesis with thalidomide for prevention of acute exacerbations and altering the natural history of multiple sclerosis.
Topics: Disease Progression; Humans; Models, Neurological; Multiple Sclerosis; Thalidomide; Tumor Necrosis F | 1999 |