thalidomide has been researched along with Lower Extremity Deformities, Congenital in 4 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Lower Extremity Deformities, Congenital: Congenital structural abnormalities of the LOWER EXTREMITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thalidomide is widely used for several diseases; however, it causes malformations in embryos exposed during pregnancy." | 7.91 | The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis. ( Fraga, LR; Gomes, JDA; Kowalski, TW; Macedo, GS; Sanseverino, MTV; Schuler-Faccini, L; Vianna, FSL, 2019) |
| "Thalidomide is widely used for several diseases; however, it causes malformations in embryos exposed during pregnancy." | 3.91 | The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis. ( Fraga, LR; Gomes, JDA; Kowalski, TW; Macedo, GS; Sanseverino, MTV; Schuler-Faccini, L; Vianna, FSL, 2019) |
| "Besides that, she was treated with schizophrenia." | 1.35 | [Thalidomide (Contergan) induced limb deficiency in Hungary?]. ( Bács, E; Czeizel, E; Gidai, J, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Donovan, KA | 1 |
| An, J | 1 |
| Nowak, RP | 1 |
| Yuan, JC | 1 |
| Fink, EC | 1 |
| Berry, BC | 1 |
| Ebert, BL | 1 |
| Fischer, ES | 1 |
| Gomes, JDA | 1 |
| Kowalski, TW | 1 |
| Fraga, LR | 1 |
| Macedo, GS | 1 |
| Sanseverino, MTV | 1 |
| Schuler-Faccini, L | 1 |
| Vianna, FSL | 1 |
| Mamopoulos, A | 1 |
| Nowak, T | 1 |
| Luther, B | 1 |
| Gidai, J | 1 |
| Bács, E | 1 |
| Czeizel, E | 1 |
4 other studies available for thalidomide and Lower Extremity Deformities, Congenital
| Article | Year |
|---|---|
Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome.
Topics: Abnormalities, Multiple; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; CYS2-HIS2 Zinc F | 2018 |
The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis.
Topics: Abnormalities, Multiple; Acetyltransferases; Brazil; Cell Line; Chromosomal Proteins, Non-Histone; C | 2019 |
Peripheral arterial reconstruction in a patient with thalidomide embryopathy and chronic occlusion of the femoral artery.
Topics: Abnormalities, Drug-Induced; Antiemetics; Arterial Occlusive Diseases; Chronic Disease; Constriction | 2013 |
[Thalidomide (Contergan) induced limb deficiency in Hungary?].
Topics: Diagnosis, Differential; Female; Femur; Fibula; Humans; Hungary; Lower Extremity Deformities, Congen | 2009 |