thalidomide has been researched along with Lichen Planus, Oral in 10 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Lichen Planus, Oral: Oral lesions accompanying cutaneous lichen planus or often occurring alone. The buccal mucosa, lips, gingivae, floor of the mouth, and palate are usually affected (in a descending order of frequency). Typically, oral lesions consist of radiating white or gray, velvety, threadlike lines, arranged in a reticular pattern, at the intersection of which there may be minute, white, elevated dots or streaks (Wickham's striae). (Jablonski, Illustrated Dictionary of Dentistry)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thalidomide was originally marked as a sedative and anti-emetic, but was withdrawn after severe teratogenic effects had been discovered." | 6.49 | Thalidomide: features and potential significance in oral precancerous conditions and oral cancer. ( Chen, Q; He, M; Huang, H; Jin, X; Lu, S; Mu, D; Wang, L; Xing, X; Zeng, X, 2013) |
| "Thalidomide was originally marked as a sedative and anti-emetic, but was withdrawn after severe teratogenic effects had been discovered." | 2.49 | Thalidomide: features and potential significance in oral precancerous conditions and oral cancer. ( Chen, Q; He, M; Huang, H; Jin, X; Lu, S; Mu, D; Wang, L; Xing, X; Zeng, X, 2013) |
| "Oral lichen planus is a very difficult condition to treat and causes patients to experience pain and difficulty eating." | 1.43 | Oral Lichen Planus Treated With Apremilast. ( Bettencourt, M, 2016) |
| "Thalidomide seems to be an effective treatment of severe corticosteroid resistant and dependent or when systemic corticosteroids are contraindicated erosive oral lichen planus." | 1.32 | [Treatment of erosive oral lichen planus with thalidomide]. ( Balguerie, X; Joly, P; Macario-Barrel, A, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Perschy, L | 1 |
| Anzengruber, F | 1 |
| Rappersberger, K | 1 |
| Itzlinger-Monshi, B | 1 |
| Aichelburg, MC | 1 |
| Graf, V | 1 |
| Hafner, J | 1 |
| Vujic, I | 1 |
| Łukaszewska-Kuska, M | 1 |
| Ślebioda, Z | 1 |
| Dorocka-Bobkowska, B | 1 |
| Bettencourt, M | 1 |
| Wu, Y | 1 |
| Zhou, G | 1 |
| Zeng, H | 1 |
| Xiong, CR | 1 |
| Lin, M | 1 |
| Zhou, HM | 1 |
| Jin, X | 1 |
| Lu, S | 1 |
| Xing, X | 1 |
| Wang, L | 1 |
| Mu, D | 1 |
| He, M | 1 |
| Huang, H | 1 |
| Zeng, X | 1 |
| Chen, Q | 1 |
| Macario-Barrel, A | 1 |
| Balguerie, X | 1 |
| Joly, P | 1 |
| Petropoulou, H | 1 |
| Kontochristopoulos, G | 1 |
| Kalogirou, O | 1 |
| Panteri, I | 1 |
| Zakopoulou, N | 1 |
| Torti, DC | 1 |
| Jorizzo, JL | 1 |
| McCarty, MA | 1 |
| Bez, C | 1 |
| Lodi, G | 1 |
| Sardella, A | 1 |
| Della Volpe, A | 1 |
| Carrassi, A | 1 |
| Camisa, C | 1 |
| Popovsky, JL | 1 |
2 reviews available for thalidomide and Lichen Planus, Oral
| Article | Year |
|---|---|
The effectiveness of topical forms of dexamethasone in the treatment of oral lichen planus- A systematic review.
Topics: Administration, Topical; Aminopyridines; Amitriptyline; Clobetasol; Dexamethasone; Humans; Ketoconaz | 2022 |
Thalidomide: features and potential significance in oral precancerous conditions and oral cancer.
Topics: Anticarcinogenic Agents; Antineoplastic Agents; Feasibility Studies; Humans; Lichen Planus, Oral; Lu | 2013 |
1 trial available for thalidomide and Lichen Planus, Oral
| Article | Year |
|---|---|
A randomized double-blind, positive-control trial of topical thalidomide in erosive oral lichen planus.
Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Chi-Square Distribution; Dexamethasone; Do | 2010 |
7 other studies available for thalidomide and Lichen Planus, Oral
| Article | Year |
|---|---|
Apremilast in oral lichen planus - a multicentric, retrospective study.
Topics: Humans; Lichen Planus, Oral; Retrospective Studies; Thalidomide | 2022 |
Oral Lichen Planus Treated With Apremilast.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Follow-Up Studies; Humans; Lichen Planus, Ora | 2016 |
[Treatment of erosive oral lichen planus with thalidomide].
Topics: Aged; Aged, 80 and over; Female; Humans; Immunosuppressive Agents; Lichen Planus, Oral; Male; Middle | 2003 |
Effective treatment of erosive lichen planus with thalidomide and topical tacrolimus.
Topics: Administration, Topical; Humans; Immunosuppressive Agents; Lichen Planus; Lichen Planus, Oral; Male; | 2006 |
Oral lichen planus: a case series with emphasis on therapy.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Female; Humans; Immunosuppressive Agents; L | 2007 |
Oral lichenoid lesions after thalidomide treatment.
Topics: Adult; Diagnosis, Differential; Female; Graft vs Host Disease; Humans; Lichen Planus, Oral; Thalidom | 1999 |
Effective treatment of oral erosive lichen planus with thalidomide.
Topics: Aged; Chronic Disease; Dermatologic Agents; Diagnosis, Differential; Humans; Lichen Planus, Oral; Ma | 2000 |