thalidomide has been researched along with Lesion of Sciatic Nerve in 1 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thalidomide was the only treatment that attenuated these increases." | 1.38 | The thalidomide analgesic effect is associated with differential TNF-α receptor expression in the dorsal horn of the spinal cord as studied in a rat model of neuropathic pain. ( Andrade, P; Buurman, WA; Daemen, MA; Del Rosario, JS; Hoogland, G; Steinbusch, HW; Visser-Vandewalle, V, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Andrade, P | 1 |
| Visser-Vandewalle, V | 1 |
| Del Rosario, JS | 1 |
| Daemen, MA | 1 |
| Buurman, WA | 1 |
| Steinbusch, HW | 1 |
| Hoogland, G | 1 |
1 other study available for thalidomide and Lesion of Sciatic Nerve
| Article | Year |
|---|---|
The thalidomide analgesic effect is associated with differential TNF-α receptor expression in the dorsal horn of the spinal cord as studied in a rat model of neuropathic pain.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Hyperalgesia; Male; Neuralgia; Pain Measurement; | 2012 |