Page last updated: 2024-11-05

thalidomide and Leprosy, Borderline

thalidomide has been researched along with Leprosy, Borderline in 5 studies

Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.

Leprosy, Borderline: A form of LEPROSY in which there are clinical manifestations of both principal types (lepromatous and tuberculoid). The disease may shift toward one of these two polar or principal forms.

Research Excerpts

ExcerptRelevanceReference
"A group of 9 Mexican lepromatous leprosy patients was studied at the beginning of a type II reaction (erythema nodosum leprosum, ENL) and after 1 or 2 months of thalidomide treatment."5.08IgG antibody subclasses, tumor necrosis factor and IFN-gamma levels in patients with type II lepra reaction on thalidomide treatment. ( Estrada-Garcia, I; Estrada-Parra, S; Favila-Castillo, L; Gomez-Melgar, M; Partida-Sanchez, S; Pedraza-Sanchez, S; Saul, A, 1998)
"Thalidomide treatment is extremely effective at ameliorating ENL symptoms."1.43Expression of CD64 on Circulating Neutrophils Favoring Systemic Inflammatory Status in Erythema Nodosum Leprosum. ( Amadeu, TP; Barbosa, MG; Brandão, SS; Costa, Fda M; Dos Santos, JB; Ferreira, H; Hacker, Mde A; Machado, Ade M; Mendes, MA; Nery, JA; Pacheco, Fdos S; Pinheiro, RO; Prata, RB; Rodrigues, LS; Sales, AM; Sarno, EN; Schmitz, V, 2016)
"Thalidomide therapy was required to treat the systemic manifestations of ENL."1.28Prolonged treatment with recombinant interferon gamma induces erythema nodosum leprosum in lepromatous leprosy patients. ( Kaplan, G; Malta, AM; Moreira, AL; Sampaio, EP; Sarno, EN, 1992)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (60.00)18.2507
2000's0 (0.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Verma, R1
Vasudevan, B1
Pragasam, V1
Moorchung, N1
Mitra, D1
Gopal, M1
Schmitz, V1
Prata, RB1
Barbosa, MG1
Mendes, MA1
Brandão, SS1
Amadeu, TP1
Rodrigues, LS1
Ferreira, H1
Costa, Fda M1
Dos Santos, JB1
Pacheco, Fdos S1
Machado, Ade M1
Nery, JA1
Hacker, Mde A1
Sales, AM1
Pinheiro, RO1
Sarno, EN3
Sampaio, EP2
Malta, AM2
Kaplan, G2
Partida-Sanchez, S1
Favila-Castillo, L1
Pedraza-Sanchez, S1
Gomez-Melgar, M1
Saul, A1
Estrada-Parra, S1
Estrada-Garcia, I1
Moreira, AL1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pilot Study to Evaluate the Efficacy and Safety of Apremilast in Patients of Chronic and Recurrent Erythema Nodosum Leprosum[NCT04822909]Phase 410 participants (Actual)Interventional2019-09-15Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for thalidomide and Leprosy, Borderline

ArticleYear
Effect of rhuIFN-gamma treatment in multibacillary leprosy patients.
    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association, 1996, Volume: 64, Issue:3

    Topics: Clofazimine; Dapsone; Drug Therapy, Combination; Erythema Nodosum; Humans; Interferon-gamma; Leprost

1996
IgG antibody subclasses, tumor necrosis factor and IFN-gamma levels in patients with type II lepra reaction on thalidomide treatment.
    International archives of allergy and immunology, 1998, Volume: 116, Issue:1

    Topics: Adolescent; Adult; Aged; Antibodies, Bacterial; Data Interpretation, Statistical; Erythema Nodosum;

1998

Other Studies

3 other studies available for thalidomide and Leprosy, Borderline

ArticleYear
Bullous erythema nodosum leprosum manifesting in the post partum period with unusual features.
    Leprosy review, 2015, Volume: 86, Issue:1

    Topics: Adult; Erythema Nodosum; Female; Humans; Leprostatic Agents; Leprosy, Borderline; Leprosy, Lepromato

2015
Expression of CD64 on Circulating Neutrophils Favoring Systemic Inflammatory Status in Erythema Nodosum Leprosum.
    PLoS neglected tropical diseases, 2016, Volume: 10, Issue:8

    Topics: Adolescent; Adult; Aged; Biopsy; Erythema Nodosum; Female; Humans; Leprostatic Agents; Leprosy, Bord

2016
Prolonged treatment with recombinant interferon gamma induces erythema nodosum leprosum in lepromatous leprosy patients.
    The Journal of experimental medicine, 1992, Jun-01, Volume: 175, Issue:6

    Topics: Erythema Nodosum; Humans; Interferon-gamma; Leprosy, Borderline; Leprosy, Lepromatous; Monocytes; Re

1992