thalidomide has been researched along with Intracranial Aneurysm in 2 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Intracranial Aneurysm: Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cerebral aneurysms were induced through hypertension and a single stereotactic injection of elastase into the basal cistern in mice." | 1.40 | Critical role of TNF-α in cerebral aneurysm formation and progression to rupture. ( Chalouhi, N; Dumont, AS; Gonzalez, LF; Greig, NH; Hasan, DM; Jabbour, PM; Owens, GK; Rosenwasser, RH; Shimada, K; Starke, RM; Tjoumakaris, SI; Wada, K, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ali, MS | 1 |
| Starke, RM | 2 |
| Jabbour, PM | 2 |
| Tjoumakaris, SI | 2 |
| Gonzalez, LF | 2 |
| Rosenwasser, RH | 2 |
| Owens, GK | 2 |
| Koch, WJ | 1 |
| Greig, NH | 2 |
| Dumont, AS | 2 |
| Chalouhi, N | 1 |
| Wada, K | 1 |
| Shimada, K | 1 |
| Hasan, DM | 1 |
2 other studies available for thalidomide and Intracranial Aneurysm
| Article | Year |
|---|---|
TNF-α induces phenotypic modulation in cerebral vascular smooth muscle cells: implications for cerebral aneurysm pathology.
Topics: Animals; Apoptosis; Carotid Arteries; Cell Differentiation; Cells, Cultured; Circle of Willis; Disea | 2013 |
Critical role of TNF-α in cerebral aneurysm formation and progression to rupture.
Topics: Aneurysm, Ruptured; Animals; Blood Pressure; Blood Vessels; Disease Models, Animal; Disease Progress | 2014 |