thalidomide has been researched along with Injuries, Radiation in 17 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although others have shown protective effects of thalidomide in disease models involving inflammation, fibrosis and blood vessel maturation, thalidomide was not able to reduce radiation-induced heart damage." | 3.79 | Thalidomide is not able to inhibit radiation-induced heart disease. ( Hoving, S; Seemann, I; Stewart, FA; te Poele, JA; Visser, NL, 2013) |
| "Thalidomide treatment demonstrated a significant mucositis-ameliorating effect during fractionated irradiation, which is likely to result from NF-κB inhibition." | 1.43 | Modulation of radiation-induced oral mucositis by thalidomide : Preclinical studies. ( Dörr, W; Frings, K; Gruber, S; Kleiter, M; Kuess, P, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (64.71) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Cheng, J | 1 |
| Jiang, J | 1 |
| He, B | 1 |
| Lin, WJ | 1 |
| Li, Y | 1 |
| Duan, J | 1 |
| Li, H | 1 |
| Huang, X | 1 |
| Cai, J | 1 |
| Xie, J | 1 |
| Zhang, Z | 1 |
| Yang, Y | 1 |
| Xu, Y | 1 |
| Hu, X | 1 |
| Wu, M | 1 |
| Zhuo, X | 1 |
| Liu, Q | 1 |
| Shi, Z | 1 |
| Yu, P | 1 |
| Rong, X | 1 |
| Ye, X | 1 |
| Saw, PE | 1 |
| Wu, LJ | 1 |
| Simone, CB | 1 |
| Chua, MLK | 1 |
| Mai, HQ | 1 |
| Tang, Y | 1 |
| Hoving, S | 1 |
| Seemann, I | 1 |
| Visser, NL | 1 |
| te Poele, JA | 1 |
| Stewart, FA | 1 |
| Frings, K | 1 |
| Gruber, S | 1 |
| Kuess, P | 1 |
| Kleiter, M | 1 |
| Dörr, W | 1 |
| Farmer, AD | 1 |
| Zanetto, U | 1 |
| Lewis, MJ | 1 |
| BAYER, R | 1 |
| ELSNER-MACKAY, P | 1 |
| LORKE, D | 1 |
| Tan, DS | 1 |
| Evanson, J | 1 |
| Plowman, PN | 1 |
| Chew, SL | 1 |
| Craanen, ME | 1 |
| van Triest, B | 1 |
| Verheijen, RH | 1 |
| Mulder, CJ | 1 |
| Majewski, F | 1 |
| François, J | 1 |
| Morgon, A | 1 |
| Charachon, D | 2 |
| Bringuier, N | 1 |
| Yager, JW | 1 |
| Tuli, SM | 1 |
| Tuchmann-Duplessis, H | 1 |
| Morgon, MA | 1 |
| Lévêque, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prospective, Open Clinical Trial of Thalidomide in the Treatment of Chronic Radiation Proctitis With Intractable Bleeding[NCT04680195] | Phase 2 | 62 participants (Anticipated) | Interventional | 2020-12-14 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for thalidomide and Injuries, Radiation
| Article | Year |
|---|---|
[EXOGENOUS MALFORMATIONS].
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Alcohols; Androgens; Anesthetics; Congenital A | 1964 |
[On certain embryopathies induced by teratogenic agents (author's transl].
Topics: Abnormalities, Drug-Induced; Aminopterin; Busulfan; Chlorambucil; Cyclophosphamide; Ethanol; Germany | 1977 |
Embryological pigment epithelial dystrophies.
Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Deafness; Female; Fluorescein Angiography; Human | 1976 |
Congenital malformations and environmental influence: the occupational environment of laboratory workers.
Topics: Abnormalities, Drug-Induced; Anesthetics; Anti-Bacterial Agents; Benzene; California; Congenital Abn | 1973 |
Certain causes of congenital malformations in Homo sapiens and their prevention.
Topics: Abnormalities, Drug-Induced; Abortion, Therapeutic; Aminopterin; Antigen-Antibody Reactions; Chromos | 1967 |
1 trial available for thalidomide and Injuries, Radiation
| Article | Year |
|---|---|
A phase 2 study of thalidomide for the treatment of radiation-induced blood-brain barrier injury.
Topics: Animals; Bevacizumab; Blood-Brain Barrier; Brain; Brain Injuries; Mice; Radiation Injuries; Thalidom | 2023 |
11 other studies available for thalidomide and Injuries, Radiation
| Article | Year |
|---|---|
Thalidomide is not able to inhibit radiation-induced heart disease.
Topics: Animals; Fibrosis; Heart; Heart Diseases; Male; Mice; Mice, Inbred C57BL; Microvessels; Radiation In | 2013 |
Modulation of radiation-induced oral mucositis by thalidomide : Preclinical studies.
Topics: Animals; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Immunosuppressive | 2016 |
Explosive proctitis: potential treatments and pitfalls in the treatment of chronic radiation proctitis.
Topics: Aged; Argon; Fatal Outcome; Humans; Laser Coagulation; Male; Multiple Organ Failure; Proctitis; Radi | 2008 |
[The significance of new exogenous noxae for the developmental damage of germ cells and ova and their prevention].
Topics: Abortion, Induced; Congenital Abnormalities; Ectromelia; Female; Fetal Death; Germ Cells; Iatrogenic | 1962 |
[EMBRYOTOXIC EFFECTS IN RATS].
Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Ethionamide; Female; Fetal Death; Hu | 1965 |
Post-radiation inflammatory reaction controlled with thalidomide and rofecoxib.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Brain Edema; Brain Neoplasms; Female; Hemangioblasto | 2004 |
Thalidomide in refractory haemorrhagic radiation induced proctitis.
Topics: Aged; Angiogenesis Inhibitors; Female; Gastrointestinal Hemorrhage; Humans; Proctitis; Radiation Inj | 2006 |
Disorders of the auditory apparatus caused by embryopathy or foetopathy: prophylaxis and treatment (a) deafness as a result of congenital malformations occurring during the first three months (b) deafness resulting from diseases of the foetus occurring af
Topics: Child, Preschool; Deafness; Ear; Ear, Inner; Female; Humans; Pregnancy; Pregnancy Complications; Rad | 1971 |
[The teratogenic risk].
Topics: Abnormalities, Drug-Induced; Animals; Azathioprine; Busulfan; Carbutamide; Congenital Abnormalities; | 1968 |
[Lesions of the auditory apparatus during pregnancy].
Topics: Abnormalities, Drug-Induced; Animals; Bacterial Infections; Deafness; Drug-Related Side Effects and | 1970 |
[Embryopathies and fetal diseases of therapeutic origin].
Topics: Abnormalities, Drug-Induced; Animals; Anti-Bacterial Agents; Anticoagulants; Antimalarials; Antineop | 1966 |