thalidomide has been researched along with Infections, Plasmodium in 3 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Indoloquinoline (IQ) is an important class of naturally occurring antimalarial alkaloids, mainly represented by cryptolepine, isocryptolepine, and neocryptolepine." | 5.22 | Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids. ( Bharate, SB; Mudududdla, R; Nuthakki, VK, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Nuthakki, VK | 1 |
| Mudududdla, R | 1 |
| Bharate, SB | 1 |
| Muniz-Junqueira, MI | 1 |
| Silva, FO | 1 |
| de Paula-Júnior, MR | 1 |
| Tosta, CE | 1 |
| Heischkeil, R | 1 |
1 review available for thalidomide and Infections, Plasmodium
| Article | Year |
|---|---|
Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids.
Topics: Alkaloids; Antimalarials; Antineoplastic Agents; Cell Proliferation; Indoles; Malaria; Molecular Str | 2022 |
2 other studies available for thalidomide and Infections, Plasmodium
| Article | Year |
|---|---|
Thalidomide influences the function of macrophages and increases the survival of Plasmodium berghei-infected CBA mice.
Topics: Animals; Hydrogen Peroxide; Immunosuppressive Agents; Macrophages, Peritoneal; Malaria; Male; Mice; | 2005 |
[Antimetabolites of folic acid metabolism with chemotherapeutic activity against rodent malaria (Plasmodium vinckei)].
Topics: Aminopterin; Animals; Cycloheximide; Female; Folic Acid; Folic Acid Antagonists; Hydantoins; Malaria | 1973 |