Page last updated: 2024-11-05

thalidomide and Infections, Klebsiella

thalidomide has been researched along with Infections, Klebsiella in 5 studies

Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.

Research Excerpts

ExcerptRelevanceReference
" Present study is designed to investigate the immunomodulatory action of thalidomide in Klebsiella pneumoniae B5055 induced acute lung infection in BALB/c mice."7.76Thalidomide treatment modulates macrophage pro-inflammatory function and cytokine levels in Klebsiella pneumoniae B5055 induced pneumonia in BALB/c mice. ( Chhibber, S; Harjai, K; Kumar, V, 2010)
"We report a case of acute fatal exacerbation of chronic hepatitis B in a 50-year-old man with multiple myeloma being treated with thalidomide."7.72Acute exacerbation of chronic hepatitis B during thalidomide therapy for multiple myeloma: a case report. ( Ahn, JY; Bang, SM; Cho, EK; Kim, SS; Lee, JH; Park, SH; Shin, DB, 2004)
"the thalidomide-alone treated mice showed 75% survival whereas 60% of the Augmentin-alone treated group survived."5.35A combination of thalidomide and augmentin protects BALB/c mice suffering from Klebsiella pneumoniae B5055-induced sepsis. ( Chhibber, S; Harjai, K; Kumar, V, 2009)
" Present study is designed to investigate the immunomodulatory action of thalidomide in Klebsiella pneumoniae B5055 induced acute lung infection in BALB/c mice."3.76Thalidomide treatment modulates macrophage pro-inflammatory function and cytokine levels in Klebsiella pneumoniae B5055 induced pneumonia in BALB/c mice. ( Chhibber, S; Harjai, K; Kumar, V, 2010)
"We report a case of acute fatal exacerbation of chronic hepatitis B in a 50-year-old man with multiple myeloma being treated with thalidomide."3.72Acute exacerbation of chronic hepatitis B during thalidomide therapy for multiple myeloma: a case report. ( Ahn, JY; Bang, SM; Cho, EK; Kim, SS; Lee, JH; Park, SH; Shin, DB, 2004)
" The animals, which received thalidomide alone orally or in combination with augmentin, 30 min prior to bacterial instillation into the lungs via intranasal route, showed significant (P<0."1.35Anti-inflammatory effect of thalidomide alone or in combination with augmentin in Klebsiella pneumoniae B5055 induced acute lung infection in BALB/c mice. ( Chhibber, S; Kumar, V, 2008)
"the thalidomide-alone treated mice showed 75% survival whereas 60% of the Augmentin-alone treated group survived."1.35A combination of thalidomide and augmentin protects BALB/c mice suffering from Klebsiella pneumoniae B5055-induced sepsis. ( Chhibber, S; Harjai, K; Kumar, V, 2009)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's3 (60.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kumar, V3
Chhibber, S3
Harjai, K2
Bang, SM1
Kim, SS1
Park, SH1
Ahn, JY1
Cho, EK1
Shin, DB1
Lee, JH1
Netea, MG1
Blok, WL1
Kullberg, BJ1
Bemelmans, M1
Vogels, MT1
Buurman, WA1
van der Meer, JW1

Other Studies

5 other studies available for thalidomide and Infections, Klebsiella

ArticleYear
Anti-inflammatory effect of thalidomide alone or in combination with augmentin in Klebsiella pneumoniae B5055 induced acute lung infection in BALB/c mice.
    European journal of pharmacology, 2008, Sep-11, Volume: 592, Issue:1-3

    Topics: Amoxicillin-Potassium Clavulanate Combination; Animals; Anti-Bacterial Agents; Anti-Inflammatory Age

2008
A combination of thalidomide and augmentin protects BALB/c mice suffering from Klebsiella pneumoniae B5055-induced sepsis.
    Journal of chemotherapy (Florence, Italy), 2009, Volume: 21, Issue:2

    Topics: Amoxicillin-Potassium Clavulanate Combination; Animals; Anti-Bacterial Agents; Drug Therapy, Combina

2009
Thalidomide treatment modulates macrophage pro-inflammatory function and cytokine levels in Klebsiella pneumoniae B5055 induced pneumonia in BALB/c mice.
    International immunopharmacology, 2010, Volume: 10, Issue:7

    Topics: Animals; Cells, Cultured; Cytokines; Inflammation Mediators; Klebsiella Infections; Klebsiella pneum

2010
Acute exacerbation of chronic hepatitis B during thalidomide therapy for multiple myeloma: a case report.
    The Korean journal of internal medicine, 2004, Volume: 19, Issue:3

    Topics: Angiogenesis Inhibitors; Hepatitis B, Chronic; Humans; Klebsiella Infections; Male; Middle Aged; Mul

2004
Pharmacologic inhibitors of tumor necrosis factor production exert differential effects in lethal endotoxemia and in infection with live microorganisms in mice.
    The Journal of infectious diseases, 1995, Volume: 171, Issue:2

    Topics: Animals; Candidiasis; Chlorpromazine; Female; Interleukin-1; Kidney; Klebsiella Infections; Klebsiel

1995