thalidomide has been researched along with Infections, Klebsiella in 5 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Present study is designed to investigate the immunomodulatory action of thalidomide in Klebsiella pneumoniae B5055 induced acute lung infection in BALB/c mice." | 7.76 | Thalidomide treatment modulates macrophage pro-inflammatory function and cytokine levels in Klebsiella pneumoniae B5055 induced pneumonia in BALB/c mice. ( Chhibber, S; Harjai, K; Kumar, V, 2010) |
| "We report a case of acute fatal exacerbation of chronic hepatitis B in a 50-year-old man with multiple myeloma being treated with thalidomide." | 7.72 | Acute exacerbation of chronic hepatitis B during thalidomide therapy for multiple myeloma: a case report. ( Ahn, JY; Bang, SM; Cho, EK; Kim, SS; Lee, JH; Park, SH; Shin, DB, 2004) |
| "the thalidomide-alone treated mice showed 75% survival whereas 60% of the Augmentin-alone treated group survived." | 5.35 | A combination of thalidomide and augmentin protects BALB/c mice suffering from Klebsiella pneumoniae B5055-induced sepsis. ( Chhibber, S; Harjai, K; Kumar, V, 2009) |
| " Present study is designed to investigate the immunomodulatory action of thalidomide in Klebsiella pneumoniae B5055 induced acute lung infection in BALB/c mice." | 3.76 | Thalidomide treatment modulates macrophage pro-inflammatory function and cytokine levels in Klebsiella pneumoniae B5055 induced pneumonia in BALB/c mice. ( Chhibber, S; Harjai, K; Kumar, V, 2010) |
| "We report a case of acute fatal exacerbation of chronic hepatitis B in a 50-year-old man with multiple myeloma being treated with thalidomide." | 3.72 | Acute exacerbation of chronic hepatitis B during thalidomide therapy for multiple myeloma: a case report. ( Ahn, JY; Bang, SM; Cho, EK; Kim, SS; Lee, JH; Park, SH; Shin, DB, 2004) |
| " The animals, which received thalidomide alone orally or in combination with augmentin, 30 min prior to bacterial instillation into the lungs via intranasal route, showed significant (P<0." | 1.35 | Anti-inflammatory effect of thalidomide alone or in combination with augmentin in Klebsiella pneumoniae B5055 induced acute lung infection in BALB/c mice. ( Chhibber, S; Kumar, V, 2008) |
| "the thalidomide-alone treated mice showed 75% survival whereas 60% of the Augmentin-alone treated group survived." | 1.35 | A combination of thalidomide and augmentin protects BALB/c mice suffering from Klebsiella pneumoniae B5055-induced sepsis. ( Chhibber, S; Harjai, K; Kumar, V, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kumar, V | 3 |
| Chhibber, S | 3 |
| Harjai, K | 2 |
| Bang, SM | 1 |
| Kim, SS | 1 |
| Park, SH | 1 |
| Ahn, JY | 1 |
| Cho, EK | 1 |
| Shin, DB | 1 |
| Lee, JH | 1 |
| Netea, MG | 1 |
| Blok, WL | 1 |
| Kullberg, BJ | 1 |
| Bemelmans, M | 1 |
| Vogels, MT | 1 |
| Buurman, WA | 1 |
| van der Meer, JW | 1 |
5 other studies available for thalidomide and Infections, Klebsiella
| Article | Year |
|---|---|
Anti-inflammatory effect of thalidomide alone or in combination with augmentin in Klebsiella pneumoniae B5055 induced acute lung infection in BALB/c mice.
Topics: Amoxicillin-Potassium Clavulanate Combination; Animals; Anti-Bacterial Agents; Anti-Inflammatory Age | 2008 |
A combination of thalidomide and augmentin protects BALB/c mice suffering from Klebsiella pneumoniae B5055-induced sepsis.
Topics: Amoxicillin-Potassium Clavulanate Combination; Animals; Anti-Bacterial Agents; Drug Therapy, Combina | 2009 |
Thalidomide treatment modulates macrophage pro-inflammatory function and cytokine levels in Klebsiella pneumoniae B5055 induced pneumonia in BALB/c mice.
Topics: Animals; Cells, Cultured; Cytokines; Inflammation Mediators; Klebsiella Infections; Klebsiella pneum | 2010 |
Acute exacerbation of chronic hepatitis B during thalidomide therapy for multiple myeloma: a case report.
Topics: Angiogenesis Inhibitors; Hepatitis B, Chronic; Humans; Klebsiella Infections; Male; Middle Aged; Mul | 2004 |
Pharmacologic inhibitors of tumor necrosis factor production exert differential effects in lethal endotoxemia and in infection with live microorganisms in mice.
Topics: Animals; Candidiasis; Chlorpromazine; Female; Interleukin-1; Kidney; Klebsiella Infections; Klebsiel | 1995 |