thalidomide has been researched along with Immune Reconstitution Disease in 10 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We report the case of an HIV-negative refugee teenager, who presented with brain tuberculomas and pseudoabscesses responsive only to thalidomide." | 7.83 | Thalidomide in Refractory Tuberculomas and Pseudoabscesses. ( Boucher, FD; Drolet, JP; Thibeault, R; Viel-Thériault, I, 2016) |
| " We report the case of an HIV-negative refugee teenager, who presented with brain tuberculomas and pseudoabscesses responsive only to thalidomide." | 3.83 | Thalidomide in Refractory Tuberculomas and Pseudoabscesses. ( Boucher, FD; Drolet, JP; Thibeault, R; Viel-Thériault, I, 2016) |
| "We concluded it was an immune reconstitution inflammatory syndrome (IRIS)." | 1.40 | A severe Whipple disease with an immune reconstitution inflammatory syndrome: an additional case of thalidomide efficiency. ( Lagier, JC; Le Blay, P; Pers, YM; Puechal, X; Rakotonirainy, H; Raoult, D, 2014) |
| "Management of relapsing or refractory immune reconstitution inflammatory syndromes (IRISs) despite corticosteroid therapy is yet to be defined." | 1.38 | Thalidomide for steroid-dependent immune reconstitution inflammatory syndromes during AIDS. ( Brunel, AS; Le Moing, V; Lortholary, O; Makinson, A; Montes, B; Reynes, J; Rubbo, PA; Tuaillon, E, 2012) |
| "Immune reconstitution inflammatory syndrome was suspected, but corticosteroid therapy failed to improve the patient." | 1.36 | Successful treatment of immune reconstitution inflammatory syndrome in Whipple's disease using thalidomide. ( Fenollar, F; Lagier, JC; Lepidi, H; Liozon, E; Raoult, D, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (90.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Qin, BE | 1 |
| Yuan, D | 1 |
| Xu, XF | 1 |
| Su, Z | 1 |
| Gu, M | 1 |
| Dai, K | 1 |
| Peng, FH | 1 |
| Jiang, Y | 1 |
| Kwon, HY | 1 |
| Han, YJ | 1 |
| Im, JH | 1 |
| Baek, JH | 1 |
| Lee, JS | 1 |
| Balasko, A | 1 |
| Keynan, Y | 1 |
| Le Blay, P | 1 |
| Rakotonirainy, H | 1 |
| Lagier, JC | 2 |
| Raoult, D | 2 |
| Puechal, X | 1 |
| Pers, YM | 1 |
| Fourcade, C | 1 |
| Mauboussin, JM | 1 |
| Lechiche, C | 1 |
| Lavigne, JP | 1 |
| Sotto, A | 1 |
| Dauby, N | 1 |
| Coussement, J | 1 |
| Karakike, E | 1 |
| Ungureanu, C | 1 |
| De Wit, S | 1 |
| Payen, MC | 1 |
| Viel-Thériault, I | 1 |
| Thibeault, R | 1 |
| Boucher, FD | 1 |
| Drolet, JP | 1 |
| Rammaert, B | 1 |
| Candon, S | 1 |
| Maunoury, C | 1 |
| Bougnoux, ME | 1 |
| Jouvion, G | 1 |
| Braun, T | 1 |
| Correas, JM | 1 |
| Lortholary, O | 2 |
| Fenollar, F | 1 |
| Lepidi, H | 1 |
| Liozon, E | 1 |
| Brunel, AS | 1 |
| Reynes, J | 1 |
| Tuaillon, E | 1 |
| Rubbo, PA | 1 |
| Montes, B | 1 |
| Le Moing, V | 1 |
| Makinson, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Efficacy and Safety of Thalidomide in the Adjuvant Treatment of Moderate New Coronavirus (COVID-19) Pneumonia: a Prospective, Multicenter, Randomized, Double-blind, Placebo, Parallel Controlled Clinical Study[NCT04273529] | Phase 2 | 100 participants (Anticipated) | Interventional | 2020-02-20 | Not yet recruiting | ||
| The Efficacy and Safety of Thalidomide Combined With Low-dose Hormones in the Treatment of Severe New Coronavirus (COVID-19) Pneumonia: a Prospective, Multicenter, Randomized, Double-blind, Placebo, Parallel Controlled Clinical Study[NCT04273581] | Phase 2 | 40 participants (Anticipated) | Interventional | 2020-02-18 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for thalidomide and Immune Reconstitution Disease
| Article | Year |
|---|---|
Shedding light on IRIS: from Pathophysiology to Treatment of Cryptococcal Meningitis and Immune Reconstitution Inflammatory Syndrome in HIV-Infected Individuals.
Topics: Adrenal Cortex Hormones; AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Clinical Tri | 2019 |
9 other studies available for thalidomide and Immune Reconstitution Disease
| Article | Year |
|---|---|
Neurological worsening during treatment of HIV-negative cryptococcal meningitis in a patient with Evans syndrome.
Topics: Adrenal Cortex Hormones; Antifungal Agents; Female; HIV Infections; Humans; Immune Reconstitution In | 2023 |
Two cases of immune reconstitution inflammatory syndrome in HIV patients treated with thalidomide.
Topics: Adult; AIDS-Related Opportunistic Infections; Antiretroviral Therapy, Highly Active; Brain Edema; Do | 2019 |
Two cases of immune reconstitution inflammatory syndrome in HIV patients treated with thalidomide.
Topics: Adult; AIDS-Related Opportunistic Infections; Antiretroviral Therapy, Highly Active; Brain Edema; Do | 2019 |
Two cases of immune reconstitution inflammatory syndrome in HIV patients treated with thalidomide.
Topics: Adult; AIDS-Related Opportunistic Infections; Antiretroviral Therapy, Highly Active; Brain Edema; Do | 2019 |
Two cases of immune reconstitution inflammatory syndrome in HIV patients treated with thalidomide.
Topics: Adult; AIDS-Related Opportunistic Infections; Antiretroviral Therapy, Highly Active; Brain Edema; Do | 2019 |
A severe Whipple disease with an immune reconstitution inflammatory syndrome: an additional case of thalidomide efficiency.
Topics: Adult; Humans; Immune Reconstitution Inflammatory Syndrome; Immunosuppressive Agents; Male; Thalidom | 2014 |
Thalidomide in the treatment of immune reconstitution inflammatory syndrome in HIV patients with neurological tuberculosis.
Topics: AIDS-Related Opportunistic Infections; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active | 2014 |
Acute myocardial infarction following thalidomide treatment for AIDS-related ulcers.
Topics: Acquired Immunodeficiency Syndrome; Adult; Coronary Angiography; Humans; Immune Reconstitution Infla | 2015 |
Thalidomide in Refractory Tuberculomas and Pseudoabscesses.
Topics: Adolescent; Antitubercular Agents; Brain; Female; Humans; Immune Reconstitution Inflammatory Syndrom | 2016 |
Thalidomide for steroid-dependent chronic disseminated candidiasis after stem cell transplantation: A case report.
Topics: Antifungal Agents; Bone Marrow Transplantation; Candida albicans; Candidiasis; Chronic Disease; Fluc | 2017 |
Successful treatment of immune reconstitution inflammatory syndrome in Whipple's disease using thalidomide.
Topics: Humans; Immune Reconstitution Inflammatory Syndrome; Immunosuppressive Agents; Male; Middle Aged; Th | 2010 |
Thalidomide for steroid-dependent immune reconstitution inflammatory syndromes during AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Antiretroviral The | 2012 |