thalidomide has been researched along with Hypoxia in 10 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Recent studies led to the development of a novel molecule RRx-001 with hypoxia-selective epigenetic and nitric oxide-donating properties." | 7.83 | A novel hypoxia-selective epigenetic agent RRx-001 triggers apoptosis and overcomes drug resistance in multiple myeloma cells. ( Anderson, KC; Chauhan, D; Das, A; Das, DS; Oronsky, B; Ray, A; Richardson, P; Scicinski, J; Song, Y; Tian, Z, 2016) |
| " Recent studies led to the development of a novel molecule RRx-001 with hypoxia-selective epigenetic and nitric oxide-donating properties." | 3.83 | A novel hypoxia-selective epigenetic agent RRx-001 triggers apoptosis and overcomes drug resistance in multiple myeloma cells. ( Anderson, KC; Chauhan, D; Das, A; Das, DS; Oronsky, B; Ray, A; Richardson, P; Scicinski, J; Song, Y; Tian, Z, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (60.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kaelin, WG | 1 |
| Kalisch-Smith, JI | 1 |
| Ved, N | 1 |
| Sparrow, DB | 1 |
| Das, DS | 1 |
| Ray, A | 1 |
| Das, A | 1 |
| Song, Y | 1 |
| Tian, Z | 1 |
| Oronsky, B | 1 |
| Richardson, P | 1 |
| Scicinski, J | 1 |
| Chauhan, D | 1 |
| Anderson, KC | 1 |
| BUECHNER, F | 1 |
| GOERTTLER, K | 1 |
| Zhao, D | 1 |
| Jiang, L | 1 |
| Hahn, EW | 1 |
| Mason, RP | 1 |
| Onishi, T | 1 |
| Jackson, BT | 1 |
| Shakibi, JG | 1 |
| Dyban, AP | 1 |
7 reviews available for thalidomide and Hypoxia
| Article | Year |
|---|---|
Environmental Risk Factors for Congenital Heart Disease.
Topics: Alcohol Drinking; Animals; Diabetes Mellitus; Environmental Exposure; Gene-Environment Interaction; | 2020 |
[ABNORMALITIES CAUSED BY TEMPORARY RESPIRATORY DISORDERS IN VERTEBRATES].
Topics: Animals; Autoradiography; Carbon Isotopes; Congenital Abnormalities; Decidua; Embryo, Mammalian; Emb | 1963 |
[ETIOPATHOGENESIS OF DEVELOPMENTAL DISORDERS. EXPERIMENTAL CONTRIBUTION TO THE CONCEPT OF PHENOCOPY].
Topics: Animals; Antimetabolites; Avitaminosis; Congenital Abnormalities; Hypoxia; Mammals; Pregnancy; Pregn | 1964 |
[Experimental congenital heart diseases].
Topics: Animals; Chickens; Cricetinae; Dactinomycin; Disease Models, Animal; Dogs; Female; Folic Acid Defici | 1972 |
The pathogenesis of congenital cardiovascular anomalies.
Topics: Abnormalities, Drug-Induced; Animals; Azo Compounds; Embryology; Female; Heart; Heart Defects, Conge | 1968 |
Etiology of congenital heart disease.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Chromosome Aberrations; Chromosome Disorders; | 1969 |
[Some current problems of experimental teratology].
Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Female; Hypoxia; Methods; Mice; Pregnancy; Rabbi | 1967 |
3 other studies available for thalidomide and Hypoxia
| Article | Year |
|---|---|
THE JEREMIAH METZGER LECTURE:VON HIPPEL-LINDAU DISEASE: INSIGHTS INTO OXYGEN SENSING, CANCER AND DRUGGING THE UNDRUGGABLE.
Topics: Carcinoma, Renal Cell; Humans; Hypoxia; Kidney Neoplasms; Ligases; Oxygen; Prolyl Hydroxylases; Thal | 2022 |
A novel hypoxia-selective epigenetic agent RRx-001 triggers apoptosis and overcomes drug resistance in multiple myeloma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Azetidines; Bortezomib; DNA (Cytosine-5-)-Methyltransfera | 2016 |
Continuous low-dose (metronomic) chemotherapy on rat prostate tumors evaluated using MRI in vivo and comparison with histology.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Area Under Curve; Cyclophosphami | 2005 |