thalidomide has been researched along with Hyperplasia in 7 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Injured carotid arteries showed marked neointimal hyperplasia, which was significantly inhibited among animals treated with thalidomide or tamoxifen: neointimal/media ratios of 1." | 7.76 | Effectiveness of thalidomide and tamoxifen in preventing neointimal hyperplasia in experimental vascular injury in rats. ( Cordeiro, AC; Dellê, H; Marinotto, DB; Noronha, IL; Santana, AC, 2010) |
| "We found that thalidomide, through its antiinflammatory and antiproliferative effects, significantly inhibits neointimal hyperplasia in balloon-injured rat carotid arteries." | 7.72 | Thalidomide as a potent inhibitor of neointimal hyperplasia after balloon injury in rat carotid artery. ( Chae, IH; Choi, DJ; Jeon, SI; Kim, DH; Kim, HS; Koo, BK; Lee, MM; Oh, BH; Park, KW; Park, SJ; Park, YB; Yang, HM; Youn, SW, 2004) |
| "Thalidomide (THD) has anti-inflammatory, immunomodulatory, antiangiogenic, and antitumor properties, which have led to its use in various autoimmune diseases, hematological malignancies, solid tumors, and other disorders." | 5.91 | A case report of thalidomide in the treatment of camrelizumab-induced reactive cutaneous capillary hyperplasia. ( Fu, S; Li, C; Wang, Z; Zhong, Y; Zhong, Z, 2023) |
| "When thalidomide was administered to OVA-challenged mice, the number of eosinophils in bronchoalveolar lavage fluid (BALF) was significantly decreased." | 5.36 | Thalidomide attenuates airway hyperresponsiveness and eosinophilic inflammation in a murine model of allergic asthma. ( Asano, T; Hasegawa, Y; Ito, S; Kume, H; Taki, F, 2010) |
| "Injured carotid arteries showed marked neointimal hyperplasia, which was significantly inhibited among animals treated with thalidomide or tamoxifen: neointimal/media ratios of 1." | 3.76 | Effectiveness of thalidomide and tamoxifen in preventing neointimal hyperplasia in experimental vascular injury in rats. ( Cordeiro, AC; Dellê, H; Marinotto, DB; Noronha, IL; Santana, AC, 2010) |
| "We found that thalidomide, through its antiinflammatory and antiproliferative effects, significantly inhibits neointimal hyperplasia in balloon-injured rat carotid arteries." | 3.72 | Thalidomide as a potent inhibitor of neointimal hyperplasia after balloon injury in rat carotid artery. ( Chae, IH; Choi, DJ; Jeon, SI; Kim, DH; Kim, HS; Koo, BK; Lee, MM; Oh, BH; Park, KW; Park, SJ; Park, YB; Yang, HM; Youn, SW, 2004) |
| "When thalidomide was administered to OVA-challenged mice, the number of eosinophils in bronchoalveolar lavage fluid (BALF) was significantly decreased." | 1.36 | Thalidomide attenuates airway hyperresponsiveness and eosinophilic inflammation in a murine model of allergic asthma. ( Asano, T; Hasegawa, Y; Ito, S; Kume, H; Taki, F, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Fu, S | 1 |
| Li, C | 1 |
| Wang, Z | 1 |
| Zhong, Z | 1 |
| Zhong, Y | 1 |
| Santana, AC | 1 |
| Marinotto, DB | 1 |
| Dellê, H | 1 |
| Cordeiro, AC | 1 |
| Noronha, IL | 1 |
| Asano, T | 1 |
| Kume, H | 1 |
| Taki, F | 1 |
| Ito, S | 1 |
| Hasegawa, Y | 1 |
| THOMAS, J | 1 |
| Park, SJ | 1 |
| Kim, HS | 1 |
| Yang, HM | 1 |
| Park, KW | 1 |
| Youn, SW | 1 |
| Jeon, SI | 1 |
| Kim, DH | 1 |
| Koo, BK | 1 |
| Chae, IH | 1 |
| Choi, DJ | 1 |
| Oh, BH | 1 |
| Lee, MM | 1 |
| Park, YB | 1 |
| McCarty, MF | 1 |
| Newman, LM | 1 |
| Hendrickx, AG | 1 |
7 other studies available for thalidomide and Hyperplasia
| Article | Year |
|---|---|
A case report of thalidomide in the treatment of camrelizumab-induced reactive cutaneous capillary hyperplasia.
Topics: Animals; China; Humans; Hyperplasia; Male; Middle Aged; Moles; Thalidomide | 2023 |
Effectiveness of thalidomide and tamoxifen in preventing neointimal hyperplasia in experimental vascular injury in rats.
Topics: Animals; Carotid Arteries; Carotid Artery Injuries; Hyperplasia; Immunohistochemistry; Male; Rats; R | 2010 |
Thalidomide attenuates airway hyperresponsiveness and eosinophilic inflammation in a murine model of allergic asthma.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; | 2010 |
[Thalidomide dysplasias of the extremities and their concomitant abnormalities].
Topics: Congenital Abnormalities; Extremities; Hyperplasia; Thalidomide | 1962 |
Thalidomide as a potent inhibitor of neointimal hyperplasia after balloon injury in rat carotid artery.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carotid Arteries; Carotid Stenosis; Catheterizatio | 2004 |
Thalidomide may impede cell migration in primates by down-regulating integrin beta-chains: potential therapeutic utility in solid malignancies, proliferative retinopathy, inflammatory disorders, neointimal hyperplasia, and osteoporosis.
Topics: Animals; Antineoplastic Agents; Callithrix; Fish Oils; Gene Expression; Humans; Hyperplasia; Inflamm | 1997 |
Temporomandibular malformations in the bonnet monkey (Macaca radiata) fetus following maternal ingestion of thalidomide.
Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Female; Fetus; Gestational A | 1985 |