Page last updated: 2024-11-05

thalidomide and Hepatitis B Virus Infection

thalidomide has been researched along with Hepatitis B Virus Infection in 3 studies

Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.

Research Excerpts

ExcerptRelevanceReference
" Recently, apremilast, a selective inhibitor of phosphodiesterase E4 has been suggested to be a safe and effective therapeutic option in HIV-infected population with psoriatic arthritis."1.51Apremilast efficacy and safety in a psoriatic arthritis patient affected by HIV and HBV virus infections. ( Bianchi, L; Campione, E; Esposito, M; Giunta, A; Manfreda, V, 2019)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Manfreda, V1
Esposito, M1
Campione, E1
Bianchi, L1
Giunta, A1
Zelenetz, AD1
Wierda, WG1
Abramson, JS1
Advani, RH1
Andreadis, CB1
Bartlett, N1
Bellam, N1
Byrd, JC1
Czuczman, MS1
Fayad, LE1
Glenn, MJ1
Gockerman, JP1
Gordon, LI1
Harris, NL1
Hoppe, RT1
Horwitz, SM1
Kelsey, CR1
Kim, YH1
Krivacic, S1
LaCasce, AS1
Nademanee, A1
Porcu, P1
Press, O1
Pro, B1
Reddy, N1
Sokol, L1
Swinnen, L1
Tsien, C1
Vose, JM1
Yahalom, J1
Zafar, N1
Dwyer, MA1
Naganuma, M1
Grigg, AP1
Sasadeusz, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Safety of Post-transplant Alpha-beta Depleted T-cell Infusion Following Haploidentical Stem Cell Transplant (Haplo SCT)[NCT02193880]7 participants (Actual)Interventional2014-10-09Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants That Experience Acute Haploidentical Alpha Beta Depleted Transplant (aGVHD)

Patients will be monitored for Grade IV aGVHD and organ toxicity. Acute assessment will be done using the modified Keystone (Glucksberg) consensus criteria. (NCT02193880)
Timeframe: From baseline and before day +100 of transplant.

InterventionParticipants (Count of Participants)
Alpha-beta Depleted T-cell Infusion0

Number of Participants That Experience Chronic Haploidentical Alpha Beta Depleted Transplant (cGVHD)

Patients will be monitored for Grade IV cGVHD and organ toxicity. Chronic assessment will be done using the conventional criteria. (NCT02193880)
Timeframe: From baseline and before day +100 of transplant.

InterventionParticipants (Count of Participants)
Alpha-beta Depleted T-cell Infusion0

Other Studies

3 other studies available for thalidomide and Hepatitis B Virus Infection

ArticleYear
Apremilast efficacy and safety in a psoriatic arthritis patient affected by HIV and HBV virus infections.
    Postgraduate medicine, 2019, Volume: 131, Issue:3

    Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Psoriatic; Hepatitis B; HIV Infectio

2019
Non-Hodgkin's lymphomas, version 1.2013.
    Journal of the National Comprehensive Cancer Network : JNCCN, 2013, Mar-01, Volume: 11, Issue:3

    Topics: Antineoplastic Agents; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis

2013
Hepatitis B reactivation after thalidomide.
    Internal medicine journal, 2008, Volume: 38, Issue:4

    Topics: Amyloidosis; Female; Hepatitis B; Humans; Immunosuppressive Agents; Kidney Diseases; Middle Aged; Re

2008