thalidomide has been researched along with Heart Septal Defects, Ventricular in 6 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Heart Septal Defects, Ventricular: Developmental abnormalities in any portion of the VENTRICULAR SEPTUM resulting in abnormal communications between the two lower chambers of the heart. Classification of ventricular septal defects is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The cats were given daily oral doses of thalidomide as follows: 10 mg/kg on days 10-20 of pregnancy, 240 mg/kg on days 10-14, and 120, 240, and 480 mg/kg on days 15-17 or 18-20 of pregnancy." | 3.65 | Fetal cardiovascular and other defects induced by thalidomide in cats. ( Khera, KS, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| SCHUMACHER, H | 1 |
| ODUNJO, F | 1 |
| Khera, KS | 1 |
| Nora, JJ | 1 |
| Nora, AH | 1 |
| Gilani, SH | 1 |
| Simcha, A | 1 |
| Vickers, TH | 1 |
1 review available for thalidomide and Heart Septal Defects, Ventricular
| Article | Year |
|---|---|
The evolution of specific genetic and environmental counseling in congenital heart diseases.
Topics: Chromosomes; Counseling; Ductus Arteriosus, Patent; Environmental Health; Heart Defects, Congenital; | 1978 |
5 other studies available for thalidomide and Heart Septal Defects, Ventricular
| Article | Year |
|---|---|
[PERSISTENT TRUNCUS ARTERIOSUS COMMUNIS IN SO-CALLED THALIDOMIDE EMBRYOPATHY].
Topics: Ductus Arteriosus; Ectromelia; Fetal Diseases; Heart Septal Defects; Heart Septal Defects, Ventricul | 1963 |
Fetal cardiovascular and other defects induced by thalidomide in cats.
Topics: Animals; Cardiomegaly; Cats; Coronary Vessels; Female; Fetal Heart; Heart Atria; Heart Defects, Cong | 1975 |
Cardiovascular malformations in the chick embryo induced by thalidomide.
Topics: Abnormalities, Drug-Induced; Animals; Aortic Arch Syndromes; Aortic Valve Stenosis; Cardiovascular A | 1973 |
Congenital heart disease in radial clubbed hand syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Female; Hand Deformities, Acquired; Heart Defe | 1971 |
The cardiovascular malformations in the rabbit thalidomide embryopathy.
Topics: Abnormalities, Drug-Induced; Animals; Aorta; Bronchial Arteries; Cardiovascular Abnormalities; Cardi | 1968 |