thalidomide has been researched along with Haemophilus influenzae Meningitis Type B in 1 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thalidomide treatment reduces TNF-alpha production in both experimental systems, but has a greater effect on the more indolent gram positive inflammatory response in which peak TNF-alpha levels in the CSF are reduced by > 50%." | 1.29 | Effect of thalidomide on the inflammatory response in cerebrospinal fluid in experimental bacterial meningitis. ( Burroughs, MH; Kaplan, G; Ossig, J; Sokol, K; Tsenova-Berkova, L; Tuomanen, E, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Burroughs, MH | 1 |
| Tsenova-Berkova, L | 1 |
| Sokol, K | 1 |
| Ossig, J | 1 |
| Tuomanen, E | 1 |
| Kaplan, G | 1 |
1 other study available for thalidomide and Haemophilus influenzae Meningitis Type B
| Article | Year |
|---|---|
Effect of thalidomide on the inflammatory response in cerebrospinal fluid in experimental bacterial meningitis.
Topics: Animals; Cerebrospinal Fluid Proteins; Disease Models, Animal; Humans; Inflammation; Interleukin-1; | 1995 |