thalidomide has been researched along with Guillain-Barre Syndrome in 3 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Guillain-Barre Syndrome: An acute inflammatory autoimmune neuritis caused by T cell- mediated cellular immune response directed towards peripheral myelin. Demyelination occurs in peripheral nerves and nerve roots. The process is often preceded by a viral or bacterial infection, surgery, immunization, lymphoma, or exposure to toxins. Common clinical manifestations include progressive weakness, loss of sensation, and loss of deep tendon reflexes. Weakness of respiratory muscles and autonomic dysfunction may occur. (From Adams et al., Principles of Neurology, 6th ed, pp1312-1314)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although peripheral neuropathies in children are often of genetic origin, acquired causes should be carefully looked for and ruled out also in the pediatric age." | 2.58 | Peripheral neuropathy and gastroenterologic disorders: an overview on an underrecognized association. ( De' Angelis, GL; Di Mario, F; Fusco, C; Gaiani, F; Leandro, G; Pisani, F; Spagnoli, C, 2018) |
| "Waldenström's macroglobulinemia is a rare B-cell malignancy defined by medullar infiltration by clonal lymphoplasmocytic cells and monoclonal IgM secretion." | 2.50 | Current and future therapeutic approach for Waldenström's macroglobulinemia. ( Choquet, S; Leblond, V; Nguyen, S; Souchet-Cömpain, L, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Spagnoli, C | 1 |
| Pisani, F | 1 |
| Di Mario, F | 1 |
| Leandro, G | 1 |
| Gaiani, F | 1 |
| De' Angelis, GL | 1 |
| Fusco, C | 1 |
| Souchet-Cömpain, L | 1 |
| Choquet, S | 1 |
| Leblond, V | 1 |
| Nguyen, S | 1 |
| Kuwabara, S | 1 |
3 reviews available for thalidomide and Guillain-Barre Syndrome
| Article | Year |
|---|---|
Peripheral neuropathy and gastroenterologic disorders: an overview on an underrecognized association.
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Campylobacter Infections; Celiac Disease; Child; Comor | 2018 |
Current and future therapeutic approach for Waldenström's macroglobulinemia.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antimetabolites, Antineoplastic; Ant | 2014 |
[Advances and perspectives in treatment for refractory neuropathies with special reference to immune-mediated neuropathies and Crow-Fukase syndrome].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; A | 2010 |