thalidomide has been researched along with Fetal Death in 44 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Fetal Death: Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5 ml dimethylformamide (DMF) on day 10, 11, or 12 of the pregnancy." | 3.66 | Embryotoxicity and teratogenicity of thalidomide in rats. ( Parkhie, M; Webb, M, 1983) |
| "Data are presented on 115 children, including three sets of twins, born in Canada in 1961 and 1962 with congenital malformations associated with the use of thalidomide by their mothers in early pregnancy." | 3.64 | CANADIAN THALIDOMIDE EXPERIENCE. ( WEBB, JF, 1963) |
| "In all studies, thalidomide was selectively toxic to development." | 1.34 | Evaluation of the developmental toxicity of lenalidomide in rabbits. ( Christian, MS; Hoberman, A; Laskin, OL; Latriano, L; Sharper, V; Stirling, DI, 2007) |
| "Cases with documented maternal alcohol abuse in pregnancy in this group were analyzed separately." | 1.28 | Congenital defects of the limbs and alcohol exposure in pregnancy: data from a population based study. ( Baird, PA; Froster, UG, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (90.91) | 18.7374 |
| 1990's | 3 (6.82) | 18.2507 |
| 2000's | 1 (2.27) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| HAGEN, EO | 1 |
| BAYER, R | 1 |
| VIZZONI, L | 1 |
| DINELLI, P | 1 |
| WEBB, JF | 1 |
| WEST, GB | 1 |
| YANZON, NA | 1 |
| RODRIGUEZDEAGNESE, LR | 1 |
| MILDENSTEIN, F | 1 |
| RUETHER, K | 1 |
| KNOCHE, C | 1 |
| KOENIG, J | 1 |
| LORKE, D | 1 |
| DROBECK, HP | 1 |
| COULSTON, F | 1 |
| CORNELIUS, D | 1 |
| Christian, MS | 1 |
| Laskin, OL | 1 |
| Sharper, V | 1 |
| Hoberman, A | 1 |
| Stirling, DI | 1 |
| Latriano, L | 1 |
| Dyban, AP | 2 |
| Akimova, IM | 1 |
| Larsen, V | 1 |
| Bredahl, E | 1 |
| Szabo, KT | 2 |
| Steelman, RL | 2 |
| Parkhie, M | 1 |
| Webb, M | 1 |
| Cohlan, SQ | 1 |
| Hook, EB | 1 |
| Regal, RR | 1 |
| Huang, PH | 1 |
| McBride, WG | 2 |
| Kennedy, GL | 1 |
| Arnold, DW | 1 |
| Keplinger, ML | 1 |
| Froster, UG | 1 |
| Baird, PA | 1 |
| Robson, JM | 1 |
| Gershbein, LL | 1 |
| Stockinger, L | 1 |
| Koch, H | 1 |
| Nudleman, KL | 1 |
| Travill, AA | 1 |
| Fratta, ID | 1 |
| Fickentscher, K | 1 |
| Köhler, F | 3 |
| Schumacher, HJ | 1 |
| Terapane, J | 1 |
| Jordan, RL | 1 |
| Wilson, JG | 2 |
| Kajii, T | 1 |
| Kida, M | 1 |
| Takahashi, K | 1 |
| Hancock, JL | 1 |
| McGovern, PT | 1 |
| Stamp, JT | 1 |
| Aeppli, L | 1 |
| Roba, J | 1 |
| Lambelin, G | 1 |
| Buu-Hoï, NP | 1 |
| Ockenfels, H | 2 |
| Honus, E | 1 |
| Vickers, TH | 1 |
| Kirchmair, H | 1 |
| Källén, B | 1 |
| Winberg, J | 1 |
| Werth, G | 1 |
| Hirth, R | 1 |
| Sinclair, JG | 1 |
| Abreu, BE | 1 |
| Wuest, HM | 1 |
| Fratta, I | 1 |
| Sigg, EB | 1 |
5 reviews available for thalidomide and Fetal Death
| Article | Year |
|---|---|
[ABNORMALLY SHORTENED EXTREMITIES 1950-1962. RESULTS OF A SURVEY].
Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Ear Deformities, Acquired; Ear, External; Ect | 1964 |
Drugs and pregnancy.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Alcoholic Beverages; Animals; Anticonvulsants; | 1980 |
[Theoretical and applied aspects of experimental teratology].
Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Dactinomycin; DNA Replication; Dose-Response Rela | 1977 |
Testing drugs for teratogenicity and their effects on fertility. The present position.
Topics: Abnormalities, Drug-Induced; Animals; Cannabis; Chlormadinone Acetate; Female; Fertility; Fetal Deat | 1970 |
Abnormalities of intrauterine development in non-human primates.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortion, Spontaneous; Animals; Antineoplastic | 1972 |
39 other studies available for thalidomide and Fetal Death
| Article | Year |
|---|---|
Drugs and congenital abnormalities.
Topics: Animals; Female; Fetal Death; Pregnancy; Pregnancy, Animal; Thalidomide | 1963 |
[The significance of new exogenous noxae for the developmental damage of germ cells and ova and their prevention].
Topics: Abortion, Induced; Congenital Abnormalities; Ectromelia; Female; Fetal Death; Germ Cells; Iatrogenic | 1962 |
[CONGENITAL MALFORMATIONS AND THALIDOMIDE].
Topics: Ectromelia; Fetal Death; Humans; Infant, Newborn; Infant, Newborn, Diseases; Thalidomide; Toxicology | 1963 |
CANADIAN THALIDOMIDE EXPERIENCE.
Topics: Abnormalities, Drug-Induced; Canada; Ectromelia; Extremities; Female; Fetal Death; Humans; Infant; I | 1963 |
TERATOGENIC ACTIVITY OF DRUGS.
Topics: Abnormalities, Drug-Induced; Fetal Death; Guanethidine; Pregnancy; Rats; Research; Reserpine; Thalid | 1964 |
[COMMENTARIES ABOUT 107 CONGENITAL MALFORMATIONS].
Topics: Abnormalities, Drug-Induced; Aminopterin; Chromosome Aberrations; Chromosome Disorders; Congenital A | 1963 |
[ON THE PRENATAL TOXICITY OF DIPHENYLPYRALINE 8-CHLOROTHEOPHYLLINATE WITH REFERENCE TO EXPERIENCES WITH THALIDOMIDE AND CAFFEINE].
Topics: Abnormalities, Drug-Induced; Anti-Allergic Agents; Caffeine; Fetal Death; Histamine H1 Antagonists; | 1964 |
[EMBRYOTOXIC EFFECTS IN RATS].
Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Ethionamide; Female; Fetal Death; Hu | 1965 |
EFFECTS OF THALIDOMIDE ON FETAL DEVELOPMENT IN RABBITS AND ON ESTABLISHMENT OF PREGNANCY IN MONKEYS.
Topics: Abnormalities, Drug-Induced; Animals; Arthrogryposis; Extremities; Fetal Death; Fetal Development; F | 1965 |
Evaluation of the developmental toxicity of lenalidomide in rabbits.
Topics: Abnormalities, Drug-Induced; Animals; Embryonic Development; Female; Fetal Death; Fetus; Lenalidomid | 2007 |
[The significance of group B vitamins and genetic factors on the reaction of the rat embryo to thalidomide].
Topics: Abnormalities, Drug-Induced; Abnormalities, Severe Teratoid; Animals; Diet; Drug Hypersensitivity; E | 1966 |
The embryotoxic effect on rabbits of monophenylbutazone (monazan) compared with phenylbutazone and thalidomide.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fertility; Fetal Death; Male; Phenylbutazone; Pregnanc | 1966 |
Effects of maternal thalidomide treatment on pregnancy, fetal development, and mortality of the offspring in random-bred mice.
Topics: Animals; Female; Fetal Death; Fetus; Mice; Pregnancy; Pregnancy, Animal; Thalidomide | 1967 |
Effects of thalidomide treatment of inbred female mice on pregnancy, fetal development, and mortality of offspring.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Female; Fetal Death; Fetus; Mice; Pregnancy; Pre | 1967 |
Embryotoxicity and teratogenicity of thalidomide in rats.
Topics: Abnormalities, Drug-Induced; Animals; Dimethylformamide; Eye Abnormalities; Female; Fetal Death; Pre | 1983 |
Representative and misrepresentative associations of birth defects in livebirths. Conditions under which relative risks greater than unity in livebirths necessarily imply relative risks greater than unity in all conceptuses.
Topics: Congenital Abnormalities; Embryo, Mammalian; Female; Fetal Death; Fetus; Humans; Infant, Newborn; Mo | 1993 |
Interaction of [glutarimide-2-14C]-thalidomide with rat embryonic DNA in vivo.
Topics: Animals; Carbon Radioisotopes; DNA; DNA Adducts; DNA Damage; Embryo, Mammalian; Female; Fetal Death; | 1997 |
Mutagenicity studies with captan, captofol, folpet and thalidomide.
Topics: Animals; Captan; Chlorine; Chloroform; Cyclohexenes; Embryo Implantation; Female; Fetal Death; Fungi | 1975 |
Congenital defects of the limbs and alcohol exposure in pregnancy: data from a population based study.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Alcoholism; Animals; British Columbia; Cocaine | 1992 |
Effect of transplanted tumor and various agents on liver regeneration during pregnancy.
Topics: Animals; Benzofurans; Carcinoma 256, Walker; Female; Fetal Death; Hepatectomy; Liver Regeneration; N | 1966 |
[Teratologic study of a new, structurally related to thalidomide, sedative-hypnotic effective compound (K-2004)].
Topics: Abdominal Muscles; Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Fetal Death; Her | 1969 |
A morphological and histochemical study of thalidomide-induced upper limb malformations in rabbit fetuses.
Topics: Abnormalities, Drug-Induced; Alkaline Phosphatase; Animals; Bone and Bones; Calcium; Cartilage; Embr | 1971 |
Nicotinamide deficiency and thalidomide: potential teratogenic disturbances in Long-Evans rats.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Animal Feed; Animals; Birth Weight; Chlorproma | 1969 |
Fetal nerve cell degeneration produced by thalidomide in rabbits.
Topics: Abnormalities, Drug-Induced; Animals; Cell Nucleolus; Cell Nucleus; Dose-Response Relationship, Drug | 1974 |
Teratogenicity and embryotoxicity of thalidomide and 3-aza-thalidomide in mice.
Topics: Abnormalities, Drug-Induced; Animals; Aza Compounds; Body Weight; Bone and Bones; Depression, Chemic | 1974 |
The teratogenic activity of a thalidomide analogue, EM 12 in rabbits, rats, and monkeys.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Bone Diseases, Developmental; Female; Fetal De | 1972 |
Thalidomide and critical period. Prescription for 113 pregnant women in a maternity.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Child; Female; Fetal Death; Fetus; Follow-Up Stu | 1973 |
Failure of gestation of goat x sheep hybrids in goats and sheep.
Topics: Animals; Azathioprine; Embryo, Mammalian; Female; Fetal Death; Fetus; Gestational Age; Goats; Hybrid | 1968 |
[Teratologic studies with imipramine in rats and rabbits. Planning and interpretation of teratologic studies under consideration of the biochemistry and toxicology of test substance].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Body Weight; Desipramine; Drug Toleranc | 1969 |
Teratological studies of p-butoxyphenylacethydroxamic acid (CP 1044 J3) in rats and rabbits.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Fetal Death; Hydroxamic Acids; Hydr | 1970 |
[The L-isomer as teratogenic principle of N-phthalyl-DL-glutamic acid].
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Fetal Death; Glutamates; Isotonic S | 1970 |
Report of Inter-Society Commission for Heart Disease Resources. Prevention of Cardiovascular Disease. Primary prevention of congenital heart disease.
Topics: Child; Chromosome Aberrations; Female; Fetal Death; Heart Defects, Congenital; Humans; Infant; Infan | 1970 |
[Teratogenic effect of N-phthalyl-DL-glutamic acid following intraperitoneal application in mice].
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Fetus; Glutamates; Mice; Phthalic Acids; | 1970 |
[Study of the thalidomide effect on chick embryo].
Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Eggs; Extremities; Female; Fetal Death; Pregnanc | 1970 |
[Malformation and liver damage. On the necessary 2nd noxa in experimental thalidomide embryopathies].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Carbon Tetrachloride; Chemical and Dr | 1967 |
A Swedish register of congenital malformations. Experience with continuous registration during 2 years with special reference to multiple malformations.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Congenital Abnormalities; Female; Fetal Death; | 1968 |
[Action of thalidomide on the rate of malformations in rats with preformed genetic damage caused by malachite green].
Topics: Abnormalities, Drug-Induced; Aniline Compounds; Animals; Coloring Agents; Dwarfism; Female; Fetal De | 1968 |
Transplacental effects of drugs in mice.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Male; Maternal-Fetal Exchange; Methylcell | 1965 |
Teratological studies in the thalidomide field.
Topics: Abnormalities, Drug-Induced; Animals; Drug Synergism; Female; Fetal Death; Hexobarbital; Mice; Pregn | 1966 |