thalidomide has been researched along with Eye Disorders in 10 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A previous study of 86 thalidomide-affected subjects with ophthalmic manifestations revealed the unexpected finding of autism in 4 of the 5 severely retarded individuals." | 3.70 | The puzzle of autism: an ophthalmologic contribution. ( Gillberg, C; Johansson, M; Miller, MT; Nilsson, EW; Strömland, K, 1998) |
| "Present knowledge of chromosomal aberrations associated with microphthalmia is surveyed, and some of the syndromes and phenocopies in the mentally retarded in which microphthalmia may be found are reviewed." | 2.35 | The heterogeneity of microphthalmia in the mentally retarded. ( Warburg, M, 1971) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (80.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sakkas, LI | 1 |
| Mavropoulos, A | 1 |
| Bogdanos, DP | 1 |
| CULLEN, JF | 1 |
| PAPST, W | 1 |
| OTTO, J | 1 |
| HONEGGER, H | 1 |
| PAPE, R | 1 |
| Duke, PS | 1 |
| Miller, MT | 1 |
| Strömland, K | 1 |
| Gillberg, C | 1 |
| Johansson, M | 1 |
| Nilsson, EW | 1 |
| Warburg, M | 1 |
| Zetterström, B | 1 |
| Schrader, KE | 1 |
2 reviews available for thalidomide and Eye Disorders
| Article | Year |
|---|---|
Phosphodiesterase 4 Inhibitors in Immune-mediated Diseases: Mode of Action, Clinical Applications, Current and Future Perspectives.
Topics: Aminopyridines; Autoimmune Diseases; Benzamides; Boron Compounds; Cyclopropanes; Eye Diseases; Human | 2017 |
The heterogeneity of microphthalmia in the mentally retarded.
Topics: Abnormalities, Multiple; Abortifacient Agents; Adolescent; Adult; Brain Injuries; Child, Preschool; | 1971 |
8 other studies available for thalidomide and Eye Disorders
| Article | Year |
|---|---|
OCULAR DEFECTS IN THALIDOMIDE BABIES.
Topics: Abnormalities, Drug-Induced; Eye; Eye Diseases; Female; Humans; Infant; Infant, Newborn; Infant, New | 1964 |
[THALIDOMIDE AND CONGENITAL ABNORMALITIES OF THE EYE].
Topics: Abnormalities, Drug-Induced; Anophthalmos; Child; Eye Diseases; Infant; Learning; Microphthalmos; Op | 1964 |
[CONTERGAN INJURY WITH EYE INVOLVEMENT].
Topics: Abnormalities, Drug-Induced; Child; Eye Diseases; Female; Learning; Microphthalmos; Pregnancy; Prena | 1964 |
[THALIDOMIDE AND CONGENITAL ABNORMALITIES OF THE EYE].
Topics: Abnormalities, Drug-Induced; Child; Eye Diseases; Female; Learning; Microphthalmos; Pregnancy; Prena | 1964 |
Ocular side effects of drug therapy.
Topics: Antimalarials; Cortisone; Digitalis Glycosides; Eye Diseases; Humans; Hyperbaric Oxygenation; Miotic | 1967 |
The puzzle of autism: an ophthalmologic contribution.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Autistic Disorder; Child; Eye Diseases; Facial Paral | 1998 |
Ocular malformations caused by thalidomide.
Topics: Child; Child, Preschool; Eye Abnormalities; Eye Diseases; Female; Humans; Male; Microphthalmos; Nyst | 1966 |
[Damages to the anterior eye segment by drugs].
Topics: Anti-Bacterial Agents; Anticoagulants; Antidepressive Agents; Cornea; Dinitrophenols; Drug-Related S | 1969 |