thalidomide has been researched along with Eye Abnormalities in 33 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Eye Abnormalities: Congenital absence of or defects in structures of the eye; may also be hereditary.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To review the association of autism spectrum disorder (ASD) in individuals manifesting thalidomide embryopathy and Möbius sequence and compare them with three new studies in which ASD was also associated with ocular and systemic malformations: (1) a Swedish study of individuals with CHARGE association (Coloboma, Heart, choanal Atresia, developmental or growth Retardation, Genital anomaly, and Ear involvement); (2) a Swedish study of Goldenhar syndrome; and (3) Brazilian Möbius syndrome (sequence) study." | 3.72 | Autism with ophthalmologic malformations: the plot thickens. ( Bandim, JM; Gillberg, C; Johansson, M; Miller, MT; Strömland, K; Ventura, L, 2004) |
| "5 ml dimethylformamide (DMF) on day 10, 11, or 12 of the pregnancy." | 3.66 | Embryotoxicity and teratogenicity of thalidomide in rats. ( Parkhie, M; Webb, M, 1983) |
| "We found that Duane syndrome and its variants were prominent in individuals who were exposed to thalidomide early in the sensitive period (days 20 to 26±)." | 2.47 | What can we learn from the thalidomide experience: an ophthalmologic perspective. ( Miller, MT; Strömland, KK, 2011) |
| "Thalidomide is a very potent teratogen capable of causing severe systemic malformations if the fetus is exposed during the sensitive period." | 2.45 | Thalidomide and misoprostol: Ophthalmologic manifestations and associations both expected and unexpected. ( Miller, MT; Strömland, K; Ventura, L, 2009) |
| "Most reported cases are associated with Duane syndrome." | 2.44 | Congenital aberrant tearing: a re-look. ( Miller, MT; Strömland, K; Ventura, L, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (54.55) | 18.7374 |
| 1990's | 7 (21.21) | 18.2507 |
| 2000's | 4 (12.12) | 29.6817 |
| 2010's | 4 (12.12) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Parsa, CF | 1 |
| Robert, MP | 1 |
| Hoyt, CS | 1 |
| Kumar, P | 1 |
| Kasiviswanathan, D | 1 |
| Sundaresan, L | 1 |
| Kathirvel, P | 1 |
| Veeriah, V | 1 |
| Dutta, P | 1 |
| Sankaranarayanan, K | 1 |
| Gupta, R | 1 |
| Chatterjee, S | 1 |
| Miller, MT | 11 |
| Strömland, K | 7 |
| Ventura, L | 3 |
| Strömland, KK | 1 |
| Yabu, T | 1 |
| Tomimoto, H | 1 |
| Taguchi, Y | 1 |
| Yamaoka, S | 1 |
| Igarashi, Y | 1 |
| Okazaki, T | 1 |
| Johansson, M | 1 |
| Bandim, JM | 1 |
| Gillberg, C | 1 |
| Parkhie, M | 1 |
| Webb, M | 1 |
| Waring, GO | 1 |
| Shields, JA | 1 |
| Apt, L | 1 |
| Gaffney, WL | 1 |
| Cant, JS | 1 |
| McCredie, J | 1 |
| Phelps, PD | 1 |
| Smithells, RW | 1 |
| Pearn, JH | 1 |
| Vickers, TH | 1 |
| Zetterström, B | 1 |
| Fabro, S | 1 |
| Smith, RL | 1 |
| Cullen, JF | 1 |
| Rafuse, EV | 1 |
| Arstikaitis, M | 1 |
| Brent, HP | 1 |
| Schmidt-Mumm, E | 1 |
| Unger, L | 1 |
| Miehlke, A | 1 |
| Stanzhevskaia, TI | 1 |
| Rasore-Quartino, A | 1 |
| Rovei, S | 1 |
| Welge-Lüssen, L | 1 |
7 reviews available for thalidomide and Eye Abnormalities
| Article | Year |
|---|---|
Congenital aberrant tearing: a re-look.
Topics: Abnormalities, Drug-Induced; Duane Retraction Syndrome; Eye Abnormalities; Female; Humans; Lacrimal | 2008 |
Thalidomide and misoprostol: Ophthalmologic manifestations and associations both expected and unexpected.
Topics: Abnormalities, Drug-Induced; Adult; Autistic Disorder; Child; Child, Preschool; Cranial Nerves; Embr | 2009 |
What can we learn from the thalidomide experience: an ophthalmologic perspective.
Topics: Abnormalities, Drug-Induced; Duane Retraction Syndrome; Eye Abnormalities; Female; Humans; Limb Defo | 2011 |
Ocular anomalies: embryological implications.
Topics: Abnormalities, Multiple; Eye Abnormalities; Humans; Syndrome; Teratology; Thalidomide | 1995 |
Teratogen update: thalidomide: a review, with a focus on ocular findings and new potential uses.
Topics: Eye Abnormalities; Female; History, 20th Century; HIV Infections; Humans; Infant, Newborn; Leprosy; | 1999 |
Thalidomide embryopathy: a model for the study of congenital incomitant horizontal strabismus.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Duane Retraction Syndrome; Embryo, Mamm | 1991 |
[Combined abnormalities of the ear and eye].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Craniofacial Dysostosis; Ear; Embryology; Eye | 1967 |
26 other studies available for thalidomide and Eye Abnormalities
| Article | Year |
|---|---|
Thromboembolism and congenital malformations: from Duane syndrome to thalidomide embryopathy.
Topics: Abducens Nerve; Abnormalities, Drug-Induced; Duane Retraction Syndrome; Eye Abnormalities; Female; F | 2013 |
No, not more talk about Duane syndrome.
Topics: Abnormalities, Drug-Induced; Duane Retraction Syndrome; Eye Abnormalities; Female; Fetal Diseases; H | 2013 |
Harvesting clues from genome wide transcriptome analysis for exploring thalidomide mediated anomalies in eye development of chick embryo: Nitric oxide rectifies the thalidomide mediated anomalies by swinging back the system to normal transcriptome pattern
Topics: Animals; Cells, Cultured; Chick Embryo; Chickens; Eye; Eye Abnormalities; Gene Expression Profiling; | 2016 |
Thalidomide-induced antiangiogenic action is mediated by ceramide through depletion of VEGF receptors, and is antagonized by sphingosine-1-phosphate.
Topics: Angiogenesis Inhibitors; Animals; DNA, Complementary; Embryo, Nonmammalian; Endothelium, Vascular; E | 2005 |
Autism with ophthalmologic malformations: the plot thickens.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Autistic Disorder; Child; Child, P | 2004 |
Embryotoxicity and teratogenicity of thalidomide in rats.
Topics: Abnormalities, Drug-Induced; Animals; Dimethylformamide; Eye Abnormalities; Female; Fetal Death; Pre | 1983 |
Thalidomide embryopathy: revisited 27 years later.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Duane Retraction Syndrome; Eye Abnormal | 1993 |
Partial unilateral cryptophthalmos with syndactyly, brachycephaly, and renal anomalies.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child, Preschool; Eye Abnormalities; Eyelids; | 1975 |
Editorial: Ocular teratogens: A commentary.
Topics: Abnormalities, Drug-Induced; Aminopterin; Child; Eye Abnormalities; Humans; Mercury; Thalidomide | 1975 |
The study of malformations "by the company they keep".
Topics: Abnormalities, Drug-Induced; Adult; Eye Abnormalities; Female; Humans; Male; Ocular Motility Disorde | 1992 |
Refractive evaluation in thalidomide embryopathy.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Cornea; Eye Abnormalities; Female; Huma | 1992 |
Ocular teratology. Observations, speculations, questions, principles reaffirmed.
Topics: Ethanol; Eye; Eye Abnormalities; Female; Gestational Age; Humans; Pregnancy; Prenatal Exposure Delay | 1992 |
Minor ocular abnormalities associated with thalidomide.
Topics: Abnormalities, Drug-Induced; Child, Preschool; Choroid; Eye Abnormalities; Female; Humans; Infant; I | 1966 |
Embryonic neuropathy. A hypothesis of neural chest injury as the pathogenesis of congenital malformations.
Topics: Abnormalities, Drug-Induced; Animals; Cell Movement; Central Nervous System; Child; Cleft Palate; Co | 1974 |
Congenital lesions of the inner ear, demonstrated by tomography.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Adult; Child; Cochlea; Ear; Ear, I | 1974 |
Defects and disabilities of thalidomide children.
Topics: Abnormalities, Drug-Induced; Arm; Child; Coloboma; Ear; Ectromelia; Eye Abnormalities; Heart Defects | 1973 |
The rabbit thalidomide embryopathy.
Topics: Abnormalities, Drug-Induced; Animals; Biliary Tract; Digestive System Abnormalities; Eye Abnormaliti | 1966 |
Ocular malformations caused by thalidomide.
Topics: Child; Child, Preschool; Eye Abnormalities; Eye Diseases; Female; Humans; Male; Microphthalmos; Nyst | 1966 |
The teratogenic activity of thalidomide in the rabbit.
Topics: Abnormalities, Drug-Induced; Animals; Eye Abnormalities; Female; Limb Deformities, Congenital; Nervo | 1966 |
Teratogenic agents and thalidomide.
Topics: Abnormalities, Drug-Induced; Coloboma; Eye Abnormalities; Female; Humans; Infant, Newborn; Male; Mic | 1966 |
Ocular findings in thalidomide children.
Topics: Abnormalities, Drug-Induced; Blepharoptosis; Canada; Coloboma; Eye Abnormalities; Female; Humans; In | 1967 |
[On ocular malformations in the dysmelia syndrome].
Topics: Abnormalities, Drug-Induced; Child; Child, Preschool; Ectromelia; Eye Abnormalities; Female; Humans; | 1966 |
[Combination of eye and ear changes in the thalidomide induced syndrome of the 1st visceral arch].
Topics: Abnormalities, Drug-Induced; Branchial Region; Ear; Eye Abnormalities; Humans; Thalidomide | 1966 |
[Characteristics of the pathogenic effect of thalidomide on the various stages of development in the chick embryo].
Topics: Abnormalities, Drug-Induced; Animals; Anophthalmos; Brain; Chick Embryo; Eye Abnormalities; Gestatio | 1966 |
[A case of thalidomide anotia].
Topics: Abnormalities, Drug-Induced; Ataxia; Blepharoptosis; Child; Ear; Eye Abnormalities; Female; Humans; | 1967 |
[Thalidomide embryopathy with peculiar eye changes].
Topics: Abnormalities, Drug-Induced; Child; Ectodermal Dysplasia; Eye Abnormalities; Eye Manifestations; Fem | 1971 |