thalidomide has been researched along with Experimental Radiation Injuries in 8 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether thalidomide prevents microvascular injury in acute radiation proctitis in white rats." | 7.74 | Thalidomide effect in endothelial cell of acute radiation proctitis. ( Chae, HS; Cho, YS; Choi, KY; Choi, W; Kang, SJ; Kim, HK; Kim, JS; Kim, KT; Rho, SY, 2008) |
| "In a previous study we have shown in a mouse model that administration of nuclear factor-kappa B (NF-κB) inhibitor thalidomide has promising therapeutic effects on early radiation cystitis (ERC) and late radiation sequelae (LRS) of the urinary bladder." | 4.02 | Effect of irradiation on the expression of E-cadherin and β-catenin in early and late radiation sequelae of the urinary bladder and its modulation by NF-κB inhibitor thalidomide. ( Dörr, W; Kleiter, M; Kowaliuk, J; Krischak, A; Sarsarshahi, S, 2021) |
| "To determine whether thalidomide prevents microvascular injury in acute radiation proctitis in white rats." | 3.74 | Thalidomide effect in endothelial cell of acute radiation proctitis. ( Chae, HS; Cho, YS; Choi, KY; Choi, W; Kang, SJ; Kim, HK; Kim, JS; Kim, KT; Rho, SY, 2008) |
| "Thalidomide (THD) has a therapeutic effect on fibrotic and inflammatory disorders." | 1.48 | Thalidomide (THD) alleviates radiation induced lung fibrosis (RILF) via down-regulation of TGF-β/Smad3 signaling pathway in an Nrf2-dependent manner. ( Bian, C; Chen, J; Qin, WJ; Wang, YY; Zhang, CY; Zhao, R; Zhe, H; Zhu, YZ; Zou, GL, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Krischak, A | 1 |
| Kowaliuk, J | 1 |
| Sarsarshahi, S | 1 |
| Dörr, W | 1 |
| Kleiter, M | 1 |
| Bian, C | 1 |
| Qin, WJ | 1 |
| Zhang, CY | 1 |
| Zou, GL | 1 |
| Zhu, YZ | 1 |
| Chen, J | 1 |
| Zhao, R | 1 |
| Wang, YY | 1 |
| Zhe, H | 1 |
| Scharpfenecker, M | 1 |
| Floot, B | 1 |
| Russell, NS | 1 |
| Coppes, RP | 1 |
| Stewart, FA | 1 |
| Kim, KT | 1 |
| Chae, HS | 1 |
| Kim, JS | 1 |
| Kim, HK | 1 |
| Cho, YS | 1 |
| Choi, W | 1 |
| Choi, KY | 1 |
| Rho, SY | 1 |
| Kang, SJ | 1 |
| LORKE, D | 1 |
| Onishi, T | 1 |
| Töndury, G | 1 |
| Lévêque, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prospective, Open Clinical Trial of Thalidomide in the Treatment of Chronic Radiation Proctitis With Intractable Bleeding[NCT04680195] | Phase 2 | 62 participants (Anticipated) | Interventional | 2020-12-14 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for thalidomide and Experimental Radiation Injuries
| Article | Year |
|---|---|
[Experimental congenital heart diseases].
Topics: Animals; Chickens; Cricetinae; Dactinomycin; Disease Models, Animal; Dogs; Female; Folic Acid Defici | 1972 |
7 other studies available for thalidomide and Experimental Radiation Injuries
| Article | Year |
|---|---|
Effect of irradiation on the expression of E-cadherin and β-catenin in early and late radiation sequelae of the urinary bladder and its modulation by NF-κB inhibitor thalidomide.
Topics: Adherens Junctions; Animals; beta Catenin; Cadherins; Cystitis; Female; Gene Expression Regulation; | 2021 |
Thalidomide (THD) alleviates radiation induced lung fibrosis (RILF) via down-regulation of TGF-β/Smad3 signaling pathway in an Nrf2-dependent manner.
Topics: A549 Cells; Animals; Cell Line, Tumor; Epithelial Cells; Female; Gene Expression Regulation; Humans; | 2018 |
Thalidomide ameliorates inflammation and vascular injury but aggravates tubular damage in the irradiated mouse kidney.
Topics: Angiogenesis Modulating Agents; Animals; Anti-Inflammatory Agents; Female; Fibrosis; Genes, sis; Glo | 2014 |
Thalidomide effect in endothelial cell of acute radiation proctitis.
Topics: Animals; Endothelial Cells; Female; Microcirculation; Proctitis; Radiation Injuries, Experimental; R | 2008 |
[EMBRYOTOXIC EFFECTS IN RATS].
Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Ethionamide; Female; Fetal Death; Hu | 1965 |
[The genesis of congenital malformations].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Antineoplastic Agents; Cell Division; C | 1967 |
[Embryopathies and fetal diseases of therapeutic origin].
Topics: Abnormalities, Drug-Induced; Animals; Anti-Bacterial Agents; Anticoagulants; Antimalarials; Antineop | 1966 |