Page last updated: 2024-11-05

thalidomide and Esophageal Diseases

thalidomide has been researched along with Esophageal Diseases in 21 studies

Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.

Esophageal Diseases: Pathological processes in the ESOPHAGUS.

Research Excerpts

ExcerptRelevanceReference
"A multicenter, double-blind, randomized, placebo-controlled clinical trial was conducted to determine the safety and efficacy of thalidomide for treating esophageal aphthous ulceration in persons infected with human immunodeficiency virus (HIV)."9.09Thalidomide for the treatment of esophageal aphthous ulcers in patients with human immunodeficiency virus infection. National Institute of Allergy and Infectious Disease AIDS Clinical Trials Group. ( Basgoz, N; Chernoff, M; Fahey, JL; Fox, L; Hooton, TM; Jackson, JB; Jacobson, JM; MacPhail, LA; Sha, BE; Shikuma, CM; Simpson, DM; Spritzler, J; Trapnell, CB; Wohl, DA; Wu, AW, 1999)
"Thalidomide appears to be highly effective for oropharyngeal apthous ulcers in HIV-infected patients."9.08A prospective trial of thalidomide for the treatment of HIV-associated idiopathic esophageal ulcers. ( Alexander, LN; Wilcox, CM, 1997)
"A multicenter, double-blind, randomized, placebo-controlled clinical trial was conducted to determine the safety and efficacy of thalidomide for treating esophageal aphthous ulceration in persons infected with human immunodeficiency virus (HIV)."5.09Thalidomide for the treatment of esophageal aphthous ulcers in patients with human immunodeficiency virus infection. National Institute of Allergy and Infectious Disease AIDS Clinical Trials Group. ( Basgoz, N; Chernoff, M; Fahey, JL; Fox, L; Hooton, TM; Jackson, JB; Jacobson, JM; MacPhail, LA; Sha, BE; Shikuma, CM; Simpson, DM; Spritzler, J; Trapnell, CB; Wohl, DA; Wu, AW, 1999)
"Thalidomide appears to be highly effective for oropharyngeal apthous ulcers in HIV-infected patients."5.08A prospective trial of thalidomide for the treatment of HIV-associated idiopathic esophageal ulcers. ( Alexander, LN; Wilcox, CM, 1997)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's16 (76.19)18.2507
2000's4 (19.05)29.6817
2010's0 (0.00)24.3611
2020's1 (4.76)2.80

Authors

AuthorsStudies
Chen, R1
Liu, X1
Hao, J1
Dadban, A1
Guillot, B1
Atiq, M1
Neff, GW1
Argyropoulos, C1
Schroer, M1
Kemmer, N1
Weber, F1
Buell, J1
Thompson, C1
Sire, S1
Fraisse, P1
Rey, D1
Jacquemin, C1
Kempf, G1
Partisani, M1
Lang, JM1
Naum, SM1
Molloy, PJ1
Kania, RJ1
McGarr, J1
Van Thiel, DH1
Couderc, LJ1
Balloul, E1
Caubarrere, I1
Domingo, P1
Ris, J1
López-Contreras, J1
DeVincenzo, JP1
Burchet, SK1
Louvel, D1
Musso, S1
Métivier, S1
Croizet, O1
Rouquet, RM1
Massip, P1
Escourrou, J1
Frexinos, J1
Bellomo, A1
Schorr-Lesnick, B1
Alexander, LN1
Wilcox, CM1
Jibaly, RM1
Moallem, H1
Fikrig, SM1
Rabinowitz, SS1
Jacobson, JM1
Spritzler, J1
Fox, L1
Fahey, JL1
Jackson, JB1
Chernoff, M1
Wohl, DA1
Wu, AW1
Hooton, TM1
Sha, BE1
Shikuma, CM1
MacPhail, LA1
Simpson, DM1
Trapnell, CB1
Basgoz, N1
Ollivier, S1
Bonnet, J1
Lemann, M1
Coffin, JC1
Modigliani, R1
Jian, R1
Bertheau, P1
Flejou, JF1
Ryan, J2
Ginsburg, PM1
Hanan, I1
Ehrenpreis, ED1
Colman, J1
Pedersen, J1
Georghiou, PR1
Kemp, RJ1
Bernardo, P1
Arrizabalaga, J1
Iribarren, JA1
Garde, C1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Thalidomide for Treatment of Oral and Esophageal Aphthous Ulcers and HIV Viremia in Patients With HIV Infection[NCT00000790]Phase 2164 participants InterventionalCompleted
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

4 trials available for thalidomide and Esophageal Diseases

ArticleYear
Thalidomide effective for AIDS-related oral ulcers.
    Lancet (London, England), 1995, Nov-11, Volume: 346, Issue:8985

    Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Esophageal Diseases; Humans; Placebos; Sto

1995
A prospective trial of thalidomide for the treatment of HIV-associated idiopathic esophageal ulcers.
    AIDS research and human retroviruses, 1997, Mar-01, Volume: 13, Issue:4

    Topics: Adult; Anti-Ulcer Agents; Esophageal Diseases; Follow-Up Studies; HIV Infections; Humans; Prospectiv

1997
Thalidomide for the treatment of esophageal aphthous ulcers in patients with human immunodeficiency virus infection. National Institute of Allergy and Infectious Disease AIDS Clinical Trials Group.
    The Journal of infectious diseases, 1999, Volume: 180, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antigens, CD; Double-Blind Method; Esophageal Diseases; E

1999
Thalidomide effective in treating AIDS-related mouth ulcers.
    AIDS patient care and STDs, 1996, Volume: 10, Issue:1

    Topics: Adult; AIDS-Related Opportunistic Infections; Esophageal Diseases; Female; Humans; Immunosuppressive

1996

Other Studies

17 other studies available for thalidomide and Esophageal Diseases

ArticleYear
Esophageal Sinus in a Patient With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
    The American journal of gastroenterology, 2020, Volume: 115, Issue:8

    Topics: Aged; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Cyclophosphamide; Deglutition Diso

2020
Oesophageal involvement in familial benign chronic pemphigus.
    Acta dermato-venereologica, 2006, Volume: 86, Issue:3

    Topics: Administration, Oral; Diagnosis, Differential; Esophageal Diseases; Esophagoscopy; Female; Humans; M

2006
Successful treatment with thalidomide in a liver transplant recipient with giant esophageal ulcers.
    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2006, Volume: 12, Issue:6

    Topics: Aged; Esophageal Diseases; Humans; Immunosuppressive Agents; Liver Transplantation; Male; Thalidomid

2006
[Efficacy of thalidomide in the treatment of esophageal ulcers in human immunodeficiency virus infection].
    Gastroenterologie clinique et biologique, 1995, Volume: 19, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Esophageal Diseases; Fatal Outcome; HIV Infections; HIV S

1995
Use of thalidomide in treatment and maintenance of idiopathic esophageal ulcers in HIV+ individuals.
    Digestive diseases and sciences, 1995, Volume: 40, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Adult; Esophageal Diseases; Female; HIV Seropositivity; HIV-1; H

1995
Esophageal ulcers in AIDS.
    Annals of internal medicine, 1996, May-15, Volume: 124, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; Anti-Ulcer Agents; Esophageal Diseases; Humans; Thalidomide; Ulc

1996
Esophageal ulcers in AIDS.
    Annals of internal medicine, 1996, May-15, Volume: 124, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; Anti-Ulcer Agents; Esophageal Diseases; Humans; Thalidomide; Ulc

1996
Prolonged thalidomide therapy for human immunodeficiency virus-associated recurrent severe esophageal and oral aphthous ulcers.
    The Pediatric infectious disease journal, 1996, Volume: 15, Issue:5

    Topics: AIDS-Related Opportunistic Infections; CD4 Lymphocyte Count; Child, Preschool; Esophageal Diseases;

1996
Idiopathic esophageal ulceration associated with human immunodeficiency virus infection: efficacy of thalidomide treatment.
    Endoscopy, 1996, Volume: 28, Issue:5

    Topics: Adult; Anti-Ulcer Agents; Esophageal Diseases; HIV Infections; Humans; Male; Thalidomide; Ulcer

1996
Thalidomide treatment for idiopathic esophageal ulcers in patients with HIV.
    Gastrointestinal endoscopy, 1996, Volume: 44, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Adult; Endoscopy, Digestive System; Esophageal Diseases; Humans;

1996
Steroid-resistant idiopathic esophageal ulcer in a child with AIDS.
    Journal of pediatric gastroenterology and nutrition, 1998, Volume: 27, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Candidiasis; Child, Preschool; Drug Resistance; Esophageal Disea

1998
Idiopathic giant oesophageal ulcer in an immunocompetent patient. The efficacy of thalidomide treatment.
    Gut, 1999, Volume: 45, Issue:3

    Topics: Esophageal Diseases; Humans; Immunocompetence; Immunosuppressive Agents; Male; Middle Aged; Thalidom

1999
Thalidomide treatment of oesophageal ulceration.
    Gut, 2000, Volume: 47, Issue:1

    Topics: Esophageal Diseases; Humans; Immunosuppressive Agents; Thalidomide; Ulcer

2000
Treatment of severe esophageal Crohn's disease with thalidomide.
    The American journal of gastroenterology, 2001, Volume: 96, Issue:4

    Topics: Aged; Aged, 80 and over; Crohn Disease; Esophageal Diseases; Female; Humans; Severity of Illness Ind

2001
Thalidomide to treat esophageal ulcer in AIDS.
    The New England journal of medicine, 1992, Jul-16, Volume: 327, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; Esophageal Diseases; Humans; Male; Thalidomide; Ulcer

1992
HIV-associated oesophageal ulcers treated with thalidomide.
    The Medical journal of Australia, 1990, Apr-02, Volume: 152, Issue:7

    Topics: Esophageal Diseases; HIV Infections; Humans; Male; Middle Aged; Thalidomide; Ulcer

1990
[Effectiveness of thalidomide in non specific esophageal ulcer in patients with acquired immunodeficiency syndrome].
    Medicina clinica, 1990, Apr-28, Volume: 94, Issue:16

    Topics: Acquired Immunodeficiency Syndrome; Adult; Esophageal Diseases; Humans; Male; Thalidomide; Ulcer

1990