thalidomide has been researched along with Esophageal Diseases in 21 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Esophageal Diseases: Pathological processes in the ESOPHAGUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A multicenter, double-blind, randomized, placebo-controlled clinical trial was conducted to determine the safety and efficacy of thalidomide for treating esophageal aphthous ulceration in persons infected with human immunodeficiency virus (HIV)." | 9.09 | Thalidomide for the treatment of esophageal aphthous ulcers in patients with human immunodeficiency virus infection. National Institute of Allergy and Infectious Disease AIDS Clinical Trials Group. ( Basgoz, N; Chernoff, M; Fahey, JL; Fox, L; Hooton, TM; Jackson, JB; Jacobson, JM; MacPhail, LA; Sha, BE; Shikuma, CM; Simpson, DM; Spritzler, J; Trapnell, CB; Wohl, DA; Wu, AW, 1999) |
| "Thalidomide appears to be highly effective for oropharyngeal apthous ulcers in HIV-infected patients." | 9.08 | A prospective trial of thalidomide for the treatment of HIV-associated idiopathic esophageal ulcers. ( Alexander, LN; Wilcox, CM, 1997) |
| "A multicenter, double-blind, randomized, placebo-controlled clinical trial was conducted to determine the safety and efficacy of thalidomide for treating esophageal aphthous ulceration in persons infected with human immunodeficiency virus (HIV)." | 5.09 | Thalidomide for the treatment of esophageal aphthous ulcers in patients with human immunodeficiency virus infection. National Institute of Allergy and Infectious Disease AIDS Clinical Trials Group. ( Basgoz, N; Chernoff, M; Fahey, JL; Fox, L; Hooton, TM; Jackson, JB; Jacobson, JM; MacPhail, LA; Sha, BE; Shikuma, CM; Simpson, DM; Spritzler, J; Trapnell, CB; Wohl, DA; Wu, AW, 1999) |
| "Thalidomide appears to be highly effective for oropharyngeal apthous ulcers in HIV-infected patients." | 5.08 | A prospective trial of thalidomide for the treatment of HIV-associated idiopathic esophageal ulcers. ( Alexander, LN; Wilcox, CM, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (76.19) | 18.2507 |
| 2000's | 4 (19.05) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, R | 1 |
| Liu, X | 1 |
| Hao, J | 1 |
| Dadban, A | 1 |
| Guillot, B | 1 |
| Atiq, M | 1 |
| Neff, GW | 1 |
| Argyropoulos, C | 1 |
| Schroer, M | 1 |
| Kemmer, N | 1 |
| Weber, F | 1 |
| Buell, J | 1 |
| Thompson, C | 1 |
| Sire, S | 1 |
| Fraisse, P | 1 |
| Rey, D | 1 |
| Jacquemin, C | 1 |
| Kempf, G | 1 |
| Partisani, M | 1 |
| Lang, JM | 1 |
| Naum, SM | 1 |
| Molloy, PJ | 1 |
| Kania, RJ | 1 |
| McGarr, J | 1 |
| Van Thiel, DH | 1 |
| Couderc, LJ | 1 |
| Balloul, E | 1 |
| Caubarrere, I | 1 |
| Domingo, P | 1 |
| Ris, J | 1 |
| López-Contreras, J | 1 |
| DeVincenzo, JP | 1 |
| Burchet, SK | 1 |
| Louvel, D | 1 |
| Musso, S | 1 |
| Métivier, S | 1 |
| Croizet, O | 1 |
| Rouquet, RM | 1 |
| Massip, P | 1 |
| Escourrou, J | 1 |
| Frexinos, J | 1 |
| Bellomo, A | 1 |
| Schorr-Lesnick, B | 1 |
| Alexander, LN | 1 |
| Wilcox, CM | 1 |
| Jibaly, RM | 1 |
| Moallem, H | 1 |
| Fikrig, SM | 1 |
| Rabinowitz, SS | 1 |
| Jacobson, JM | 1 |
| Spritzler, J | 1 |
| Fox, L | 1 |
| Fahey, JL | 1 |
| Jackson, JB | 1 |
| Chernoff, M | 1 |
| Wohl, DA | 1 |
| Wu, AW | 1 |
| Hooton, TM | 1 |
| Sha, BE | 1 |
| Shikuma, CM | 1 |
| MacPhail, LA | 1 |
| Simpson, DM | 1 |
| Trapnell, CB | 1 |
| Basgoz, N | 1 |
| Ollivier, S | 1 |
| Bonnet, J | 1 |
| Lemann, M | 1 |
| Coffin, JC | 1 |
| Modigliani, R | 1 |
| Jian, R | 1 |
| Bertheau, P | 1 |
| Flejou, JF | 1 |
| Ryan, J | 2 |
| Ginsburg, PM | 1 |
| Hanan, I | 1 |
| Ehrenpreis, ED | 1 |
| Colman, J | 1 |
| Pedersen, J | 1 |
| Georghiou, PR | 1 |
| Kemp, RJ | 1 |
| Bernardo, P | 1 |
| Arrizabalaga, J | 1 |
| Iribarren, JA | 1 |
| Garde, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Thalidomide for Treatment of Oral and Esophageal Aphthous Ulcers and HIV Viremia in Patients With HIV Infection[NCT00000790] | Phase 2 | 164 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for thalidomide and Esophageal Diseases
| Article | Year |
|---|---|
Thalidomide effective for AIDS-related oral ulcers.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Esophageal Diseases; Humans; Placebos; Sto | 1995 |
A prospective trial of thalidomide for the treatment of HIV-associated idiopathic esophageal ulcers.
Topics: Adult; Anti-Ulcer Agents; Esophageal Diseases; Follow-Up Studies; HIV Infections; Humans; Prospectiv | 1997 |
Thalidomide for the treatment of esophageal aphthous ulcers in patients with human immunodeficiency virus infection. National Institute of Allergy and Infectious Disease AIDS Clinical Trials Group.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antigens, CD; Double-Blind Method; Esophageal Diseases; E | 1999 |
Thalidomide effective in treating AIDS-related mouth ulcers.
Topics: Adult; AIDS-Related Opportunistic Infections; Esophageal Diseases; Female; Humans; Immunosuppressive | 1996 |
17 other studies available for thalidomide and Esophageal Diseases
| Article | Year |
|---|---|
Esophageal Sinus in a Patient With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Topics: Aged; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Cyclophosphamide; Deglutition Diso | 2020 |
Oesophageal involvement in familial benign chronic pemphigus.
Topics: Administration, Oral; Diagnosis, Differential; Esophageal Diseases; Esophagoscopy; Female; Humans; M | 2006 |
Successful treatment with thalidomide in a liver transplant recipient with giant esophageal ulcers.
Topics: Aged; Esophageal Diseases; Humans; Immunosuppressive Agents; Liver Transplantation; Male; Thalidomid | 2006 |
[Efficacy of thalidomide in the treatment of esophageal ulcers in human immunodeficiency virus infection].
Topics: Acquired Immunodeficiency Syndrome; Adult; Esophageal Diseases; Fatal Outcome; HIV Infections; HIV S | 1995 |
Use of thalidomide in treatment and maintenance of idiopathic esophageal ulcers in HIV+ individuals.
Topics: Acquired Immunodeficiency Syndrome; Adult; Esophageal Diseases; Female; HIV Seropositivity; HIV-1; H | 1995 |
Esophageal ulcers in AIDS.
Topics: Acquired Immunodeficiency Syndrome; Anti-Ulcer Agents; Esophageal Diseases; Humans; Thalidomide; Ulc | 1996 |
Esophageal ulcers in AIDS.
Topics: Acquired Immunodeficiency Syndrome; Anti-Ulcer Agents; Esophageal Diseases; Humans; Thalidomide; Ulc | 1996 |
Prolonged thalidomide therapy for human immunodeficiency virus-associated recurrent severe esophageal and oral aphthous ulcers.
Topics: AIDS-Related Opportunistic Infections; CD4 Lymphocyte Count; Child, Preschool; Esophageal Diseases; | 1996 |
Idiopathic esophageal ulceration associated with human immunodeficiency virus infection: efficacy of thalidomide treatment.
Topics: Adult; Anti-Ulcer Agents; Esophageal Diseases; HIV Infections; Humans; Male; Thalidomide; Ulcer | 1996 |
Thalidomide treatment for idiopathic esophageal ulcers in patients with HIV.
Topics: Acquired Immunodeficiency Syndrome; Adult; Endoscopy, Digestive System; Esophageal Diseases; Humans; | 1996 |
Steroid-resistant idiopathic esophageal ulcer in a child with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Candidiasis; Child, Preschool; Drug Resistance; Esophageal Disea | 1998 |
Idiopathic giant oesophageal ulcer in an immunocompetent patient. The efficacy of thalidomide treatment.
Topics: Esophageal Diseases; Humans; Immunocompetence; Immunosuppressive Agents; Male; Middle Aged; Thalidom | 1999 |
Thalidomide treatment of oesophageal ulceration.
Topics: Esophageal Diseases; Humans; Immunosuppressive Agents; Thalidomide; Ulcer | 2000 |
Treatment of severe esophageal Crohn's disease with thalidomide.
Topics: Aged; Aged, 80 and over; Crohn Disease; Esophageal Diseases; Female; Humans; Severity of Illness Ind | 2001 |
Thalidomide to treat esophageal ulcer in AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; Esophageal Diseases; Humans; Male; Thalidomide; Ulcer | 1992 |
HIV-associated oesophageal ulcers treated with thalidomide.
Topics: Esophageal Diseases; HIV Infections; Humans; Male; Middle Aged; Thalidomide; Ulcer | 1990 |
[Effectiveness of thalidomide in non specific esophageal ulcer in patients with acquired immunodeficiency syndrome].
Topics: Acquired Immunodeficiency Syndrome; Adult; Esophageal Diseases; Humans; Male; Thalidomide; Ulcer | 1990 |