thalidomide has been researched along with Epiphora in 5 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A previous study of 86 thalidomide-affected subjects with ophthalmic manifestations revealed the unexpected finding of autism in 4 of the 5 severely retarded individuals." | 3.70 | The puzzle of autism: an ophthalmologic contribution. ( Gillberg, C; Johansson, M; Miller, MT; Nilsson, EW; Strömland, K, 1998) |
| "Thalidomide is a very potent teratogen capable of causing severe systemic malformations if the fetus is exposed during the sensitive period." | 2.45 | Thalidomide and misoprostol: Ophthalmologic manifestations and associations both expected and unexpected. ( Miller, MT; Strömland, K; Ventura, L, 2009) |
| "Most reported cases are associated with Duane syndrome." | 2.44 | Congenital aberrant tearing: a re-look. ( Miller, MT; Strömland, K; Ventura, L, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Norris, MR | 1 |
| Bielory, L | 1 |
| Miller, MT | 4 |
| Strömland, K | 4 |
| Ventura, L | 2 |
| Gillberg, C | 1 |
| Johansson, M | 1 |
| Nilsson, EW | 1 |
2 reviews available for thalidomide and Epiphora
| Article | Year |
|---|---|
Congenital aberrant tearing: a re-look.
Topics: Abnormalities, Drug-Induced; Duane Retraction Syndrome; Eye Abnormalities; Female; Humans; Lacrimal | 2008 |
Thalidomide and misoprostol: Ophthalmologic manifestations and associations both expected and unexpected.
Topics: Abnormalities, Drug-Induced; Adult; Autistic Disorder; Child; Child, Preschool; Cranial Nerves; Embr | 2009 |
3 other studies available for thalidomide and Epiphora
| Article | Year |
|---|---|
Chronic tearing induced by apremilast.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Conjunctivitis; Cyclic Nucleotide Phosphodiesterases, Type | 2018 |
Thalidomide embryopathy: revisited 27 years later.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Duane Retraction Syndrome; Eye Abnormal | 1993 |
The puzzle of autism: an ophthalmologic contribution.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Autistic Disorder; Child; Eye Diseases; Facial Paral | 1998 |