thalidomide has been researched along with Epilepsy in 6 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The possibility of epilepsy resulting from maternal thalidomide ingestion was investigated by obtaining a telephoned neurological history from all suspect families in the United Kingdom in which the specific diagnosis was uncertain." | 7.65 | Epilepsy: a neurological complication of thalidomide embryopathy. ( Stephenson, JB, 1976) |
| "The possibility of epilepsy resulting from maternal thalidomide ingestion was investigated by obtaining a telephoned neurological history from all suspect families in the United Kingdom in which the specific diagnosis was uncertain." | 3.65 | Epilepsy: a neurological complication of thalidomide embryopathy. ( Stephenson, JB, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Hao, Y | 1 |
| Ou, Y | 1 |
| Zhang, C | 1 |
| Chen, H | 1 |
| Yue, H | 1 |
| Yang, Z | 1 |
| Zhong, X | 1 |
| Hu, W | 1 |
| Sun, P | 1 |
| Palencia, G | 1 |
| Martinez-Juarez, IE | 1 |
| Calderon, A | 1 |
| Artigas, C | 1 |
| Sotelo, J | 1 |
| Stephenson, JB | 1 |
| Kanno, O | 1 |
| Newman, CG | 1 |
| Shiono, H | 1 |
1 review available for thalidomide and Epilepsy
| Article | Year |
|---|---|
[Diseases and dermatoglyphics].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Bone and Bones; Chromosome Aberrations; Chromo | 1970 |
1 trial available for thalidomide and Epilepsy
| Article | Year |
|---|---|
Thalidomide for treatment of refractory epilepsy.
Topics: Analysis of Variance; Epilepsy; Follow-Up Studies; Humans; Immunosuppressive Agents; Statistics, Non | 2010 |
4 other studies available for thalidomide and Epilepsy
| Article | Year |
|---|---|
Seratrodast, a thromboxane A2 receptor antagonist, inhibits neuronal ferroptosis by promoting GPX4 expression and suppressing JNK phosphorylation.
Topics: Animals; Benzoquinones; Epilepsy; Ferroptosis; Glutathione; Heptanoic Acids; Mice; Pentylenetetrazol | 2022 |
Epilepsy: a neurological complication of thalidomide embryopathy.
Topics: Adolescent; Ear; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Female; Heart Defects, C | 1976 |
Electroencephalographic study of 137 patients with thalidomide embryopathy.
Topics: Adolescent; Adult; Brain; Child; Electroencephalography; Epilepsy; Female; Fetal Diseases; Hearing D | 1987 |
Teratogen update: clinical aspects of thalidomide embryopathy--a continuing preoccupation.
Topics: Abdomen; Abnormalities, Multiple; Cardiovascular Abnormalities; Cranial Nerves; Dentition; Embryo, M | 1985 |