thalidomide has been researched along with Endotoxin Shock in 8 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 62 year-old Caucasian man with hypertension and a 4-year history of multiple myeloma, had been previously treated with lenalidomide, bortezomib and two autologous hematopoietic stem cell transplants." | 7.80 | Renal thrombotic microangiopathy and podocytopathy associated with the use of carfilzomib in a patient with multiple myeloma. ( Hobeika, L; Self, SE; Velez, JC, 2014) |
| "We report a case of acute fatal exacerbation of chronic hepatitis B in a 50-year-old man with multiple myeloma being treated with thalidomide." | 7.72 | Acute exacerbation of chronic hepatitis B during thalidomide therapy for multiple myeloma: a case report. ( Ahn, JY; Bang, SM; Cho, EK; Kim, SS; Lee, JH; Park, SH; Shin, DB, 2004) |
| "A 62 year-old Caucasian man with hypertension and a 4-year history of multiple myeloma, had been previously treated with lenalidomide, bortezomib and two autologous hematopoietic stem cell transplants." | 3.80 | Renal thrombotic microangiopathy and podocytopathy associated with the use of carfilzomib in a patient with multiple myeloma. ( Hobeika, L; Self, SE; Velez, JC, 2014) |
| "We report a case of acute fatal exacerbation of chronic hepatitis B in a 50-year-old man with multiple myeloma being treated with thalidomide." | 3.72 | Acute exacerbation of chronic hepatitis B during thalidomide therapy for multiple myeloma: a case report. ( Ahn, JY; Bang, SM; Cho, EK; Kim, SS; Lee, JH; Park, SH; Shin, DB, 2004) |
| "Thalidomide treatment did not protect normal mice from death but decreased remote lesion occurrence, with concurrent reduced bacterial counts recoverable from blood." | 1.33 | Lethal outcome caused by Porphyromonas gingivalis A7436 in a mouse chamber model is associated with elevated titers of host serum interferon-gamma. ( Hu, SW; Huang, JH; Lai, YY; Lin, YY, 2006) |
| "Thalidomide treatment did not interfere with the production of GM-CSF, IL-1 beta, or IFN-gamma." | 1.30 | Thalidomide protects mice against LPS-induced shock. ( Kaplan, G; Moreira, AL; Sarno, EN; Wang, J, 1997) |
| "Mortality caused by septic shock in experimental animals is reduced by thalidomide, an inhibitor of tumour necrosis factor alpha." | 1.30 | Protective effect of pentoxifylline plus thalidomide against septic shock in mice. ( Arrieta, O; Calvillo, M; Ortiz-Reyes, A; Rembao, D; Rivera, E; Sotelo, J, 1999) |
| "Thalidomide treated rats had lower TNF levels at all time points (P = <0." | 1.29 | Thalidomide inhibits TNF response and increases survival following endotoxin injection in rats. ( Condon, M; Hsieh, J; Murphy, T; Rush, B; Schmidt, H; Simonian, G, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hobeika, L | 1 |
| Self, SE | 1 |
| Velez, JC | 1 |
| Bang, SM | 1 |
| Kim, SS | 1 |
| Park, SH | 1 |
| Ahn, JY | 1 |
| Cho, EK | 1 |
| Shin, DB | 1 |
| Lee, JH | 1 |
| Alexandre-Moreira, MS | 1 |
| Takiya, CM | 1 |
| de Arruda, LB | 1 |
| Pascarelli, B | 1 |
| Gomes, RN | 1 |
| Castro Faria Neto, HC | 1 |
| Lima, LM | 1 |
| Barreiro, EJ | 1 |
| Huang, JH | 1 |
| Lin, YY | 1 |
| Lai, YY | 1 |
| Hu, SW | 1 |
| Netea, MG | 1 |
| Blok, WL | 1 |
| Kullberg, BJ | 1 |
| Bemelmans, M | 1 |
| Vogels, MT | 1 |
| Buurman, WA | 1 |
| van der Meer, JW | 1 |
| Schmidt, H | 1 |
| Rush, B | 1 |
| Simonian, G | 1 |
| Murphy, T | 1 |
| Hsieh, J | 1 |
| Condon, M | 1 |
| Moreira, AL | 1 |
| Wang, J | 1 |
| Sarno, EN | 1 |
| Kaplan, G | 1 |
| Arrieta, O | 1 |
| Ortiz-Reyes, A | 1 |
| Rembao, D | 1 |
| Calvillo, M | 1 |
| Rivera, E | 1 |
| Sotelo, J | 1 |
8 other studies available for thalidomide and Endotoxin Shock
| Article | Year |
|---|---|
Renal thrombotic microangiopathy and podocytopathy associated with the use of carfilzomib in a patient with multiple myeloma.
Topics: Acute Kidney Injury; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Boronic | 2014 |
Acute exacerbation of chronic hepatitis B during thalidomide therapy for multiple myeloma: a case report.
Topics: Angiogenesis Inhibitors; Hepatitis B, Chronic; Humans; Klebsiella Infections; Male; Middle Aged; Mul | 2004 |
LASSBio-468: a new achiral thalidomide analogue which modulates TNF-alpha and NO production and inhibits endotoxic shock and arthritis in an animal model.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Gene Expression; Indoles; Isoindoles; Li | 2005 |
Lethal outcome caused by Porphyromonas gingivalis A7436 in a mouse chamber model is associated with elevated titers of host serum interferon-gamma.
Topics: Animals; Antibodies; Bacteremia; Bacteroidaceae Infections; Cause of Death; Colony Count, Microbial; | 2006 |
Pharmacologic inhibitors of tumor necrosis factor production exert differential effects in lethal endotoxemia and in infection with live microorganisms in mice.
Topics: Animals; Candidiasis; Chlorpromazine; Female; Interleukin-1; Kidney; Klebsiella Infections; Klebsiel | 1995 |
Thalidomide inhibits TNF response and increases survival following endotoxin injection in rats.
Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Endotoxins; Escherichia coli; Lipop | 1996 |
Thalidomide protects mice against LPS-induced shock.
Topics: Animals; Female; Immunosuppressive Agents; Lipopolysaccharides; Mice; Shock, Septic; Thalidomide | 1997 |
Protective effect of pentoxifylline plus thalidomide against septic shock in mice.
Topics: Animals; Drug Therapy, Combination; Immunosuppressive Agents; Kidney; Liver; Male; Mice; Mice, Inbre | 1999 |