thalidomide has been researched along with Encephalopathy, Traumatic in 4 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Quelling microglial-induced excessive neuroinflammation is a potential treatment strategy across neurological disorders, including traumatic brain injury (TBI), and can be achieved by thalidomide-like drugs albeit this approved drug class is compromised by potential teratogenicity." | 8.31 | Novel, thalidomide-like, non-cereblon binding drug tetrafluorobornylphthalimide mitigates inflammation and brain injury. ( Baig, AM; Chiang, YH; Greig, NH; Hoffer, BJ; Hsueh, SC; Hwang, I; Kim, DS; Kim, S; Kim, YK; Lecca, D; Luo, W; Tweedie, D; Vargesson, N, 2023) |
| "Quelling microglial-induced excessive neuroinflammation is a potential treatment strategy across neurological disorders, including traumatic brain injury (TBI), and can be achieved by thalidomide-like drugs albeit this approved drug class is compromised by potential teratogenicity." | 4.31 | Novel, thalidomide-like, non-cereblon binding drug tetrafluorobornylphthalimide mitigates inflammation and brain injury. ( Baig, AM; Chiang, YH; Greig, NH; Hoffer, BJ; Hsueh, SC; Hwang, I; Kim, DS; Kim, S; Kim, YK; Lecca, D; Luo, W; Tweedie, D; Vargesson, N, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lecca, D | 2 |
| Hsueh, SC | 1 |
| Luo, W | 3 |
| Tweedie, D | 3 |
| Kim, DS | 2 |
| Baig, AM | 1 |
| Vargesson, N | 1 |
| Kim, YK | 1 |
| Hwang, I | 1 |
| Kim, S | 1 |
| Hoffer, BJ | 4 |
| Chiang, YH | 2 |
| Greig, NH | 4 |
| Huang, PS | 1 |
| Tsai, PY | 1 |
| Yang, LY | 1 |
| Wang, JY | 5 |
| Batsaikhan, B | 1 |
| Scerba, MT | 1 |
| Miller, JP | 1 |
| Lin, CT | 1 |
| Huang, YN | 1 |
| Chiu, CC | 1 |
| Pick, CG | 1 |
| Chou, SY | 1 |
| Luo, Y | 1 |
4 other studies available for thalidomide and Encephalopathy, Traumatic
| Article | Year |
|---|---|
Novel, thalidomide-like, non-cereblon binding drug tetrafluorobornylphthalimide mitigates inflammation and brain injury.
Topics: Animals; Brain Injuries; Brain Injuries, Traumatic; Chick Embryo; Humans; Immunomodulating Agents; I | 2023 |
3,6'-Dithiopomalidomide Ameliorates Hippocampal Neurodegeneration, Microgliosis and Astrogliosis and Improves Cognitive Behaviors in Rats with a Moderate Traumatic Brain Injury.
Topics: Animals; Brain Injuries, Traumatic; Cognition; Gliosis; Hippocampus; Immunologic Factors; Male; Memo | 2021 |
Post-Injury Neuroprotective Effects of the Thalidomide Analog 3,6'-Dithiothalidomide on Traumatic Brain Injury.
Topics: Animals; Anti-Inflammatory Agents; Brain Injuries, Traumatic; Cell Line; Male; Mice; Neurons; Neurop | 2019 |
Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat.
Topics: Animals; Apoptosis; Brain Injuries, Traumatic; Cells, Cultured; Cerebral Cortex; Cytokines; Disease | 2016 |