thalidomide has been researched along with Diabetic Neuropathies in 7 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Diabetic Neuropathies: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
| Excerpt | Relevance | Reference |
|---|---|---|
| " To this end, we used Zucker diabetic fatty (ZDF) rats to examine the levels of TNFα, IL-1β, and NF-κB in the RVM during the development of neuropathic pain in type 2 diabetes, and evaluated the effects of intra-RVM microinjections of thalidomide on the levels of TNFα, IL-1β, and NF-κB in the RVM and mechanical allodynia and thermal hyperalgesia induced by type 2 diabetes." | 3.83 | Administrations of thalidomide into the rostral ventromedial medulla alleviates painful diabetic neuropathy in Zucker diabetic fatty rats. ( Gu, K; Guan, J; Liu, J; Ma, P; Song, T; Yang, G; Yang, Y; Zhang, Z; Zhao, J, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, Y | 1 |
| Zang, Y | 1 |
| Zhou, L | 1 |
| Gui, W | 1 |
| Liu, X | 1 |
| Zhong, Y | 1 |
| Yang, Y | 2 |
| Zhang, Z | 2 |
| Guan, J | 1 |
| Liu, J | 2 |
| Ma, P | 2 |
| Gu, K | 2 |
| Zhao, J | 2 |
| Yang, G | 1 |
| Song, T | 2 |
| Wang, H | 1 |
| Shen, L | 1 |
| Wang, W | 1 |
| Chauhan, N | 1 |
| Taliyan, R | 1 |
| Sharma, PL | 1 |
| Pitini, V | 1 |
| Arrigo, C | 1 |
| Aloi, G | 1 |
| Azzarello, D | 1 |
| La Gattuta, G | 1 |
| Thomas, PK | 1 |
| Gibbels, E | 1 |
1 review available for thalidomide and Diabetic Neuropathies
| Article | Year |
|---|---|
The morphological basis for alterations in nerve conduction in peripheral neuropathy.
Topics: Amyloidosis; Animals; Axons; Beriberi; Cresols; Demyelinating Diseases; Diabetic Neuropathies; Diffu | 1971 |
6 other studies available for thalidomide and Diabetic Neuropathies
| Article | Year |
|---|---|
The role of TNF-alpha/NF-kappa B pathway on the up-regulation of voltage-gated sodium channel Nav1.7 in DRG neurons of rats with diabetic neuropathy.
Topics: Animals; Cells, Cultured; Diabetic Neuropathies; Ganglia, Spinal; Male; NAV1.7 Voltage-Gated Sodium | 2014 |
Administrations of thalidomide into the rostral ventromedial medulla alleviates painful diabetic neuropathy in Zucker diabetic fatty rats.
Topics: Animals; Blood Glucose; Body Weight; Cytokines; Diabetic Neuropathies; Hyperalgesia; Immunosuppressi | 2016 |
Thalidomide Promotes Morphine Efficacy and Prevents Morphine-Induced Tolerance in Rats with Diabetic Neuropathy.
Topics: Analgesics, Opioid; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drug Synergism; | 2016 |
Effect of dipyrone and thalidomide alone and in combination on STZ-induced diabetic neuropathic pain.
Topics: Analgesics, Non-Narcotic; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropat | 2012 |
Diabetic foot disease in a patient with multiple myeloma receiving thalidomide.
Topics: Angiogenesis Inhibitors; Collateral Circulation; Combined Modality Therapy; Diabetes Mellitus, Type | 2002 |
[Differential diagnosis of polyneuritides].
Topics: Arsenic Poisoning; Carbon Disulfide; Diabetic Neuropathies; Diagnosis, Differential; Diphtheria; Hum | 1969 |