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thalidomide and Diabetic Cardiomyopathies

thalidomide has been researched along with Diabetic Cardiomyopathies in 1 studies

Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.

Diabetic Cardiomyopathies: Diabetes complications in which VENTRICULAR REMODELING in the absence of CORONARY ATHEROSCLEROSIS and hypertension results in cardiac dysfunctions, typically LEFT VENTRICULAR DYSFUNCTION. The changes also result in myocardial hypertrophy, myocardial necrosis and fibrosis, and collagen deposition due to impaired glucose tolerance.

Research Excerpts

ExcerptRelevanceReference
"We induced type 1 diabetes using streptozocin in 8-week-old Sprague-Dawley rats, divided them into two groups-a thalidomide treatment group (DM-T, n = 15) and a non-treatment group (DM-N, n = 15)-and compared them with a normal control (n = 10)."1.36The protective effect of thalidomide on left ventricular function in a rat model of diabetic cardiomyopathy. ( Chang, HJ; Chang, SA; Kim, DH; Kim, HK; Kim, HN; Kim, YJ; Lee, HW; Park, YB; Sohn, DW, 2010)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kim, DH1
Kim, YJ1
Chang, SA1
Lee, HW1
Kim, HN1
Kim, HK1
Chang, HJ1
Sohn, DW1
Park, YB1

Other Studies

1 other study available for thalidomide and Diabetic Cardiomyopathies

ArticleYear
The protective effect of thalidomide on left ventricular function in a rat model of diabetic cardiomyopathy.
    European journal of heart failure, 2010, Volume: 12, Issue:10

    Topics: Analysis of Variance; Animals; Antibiotics, Antineoplastic; Collagen; Diabetes Mellitus, Type 1; Dia

2010
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