thalidomide has been researched along with Diabetes Mellitus, Type 1 in 4 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We induced type 1 diabetes using streptozocin in 8-week-old Sprague-Dawley rats, divided them into two groups-a thalidomide treatment group (DM-T, n = 15) and a non-treatment group (DM-N, n = 15)-and compared them with a normal control (n = 10)." | 1.36 | The protective effect of thalidomide on left ventricular function in a rat model of diabetic cardiomyopathy. ( Chang, HJ; Chang, SA; Kim, DH; Kim, HK; Kim, HN; Kim, YJ; Lee, HW; Park, YB; Sohn, DW, 2010) |
| "Thalidomide did not suppress the incidence of lymphocytic thyroiditis and serum anti-thyroglobulin antibodies or affect the serum concentrations of T4, T3 and TSH in this rat model." | 1.28 | Effect of thalidomide on the incidence of iodine-induced and spontaneous lymphocytic thyroiditis and spontaneous diabetes mellitus in the BB/Wor rat. ( Abend, S; Alex, S; Appel, MC; Braverman, LE; Lueprasitsakul, W; Reinhardt, W, 1990) |
| "To evaluate the patterns of birth defects associated with diabetic embryopathy, a sensitivity-specificity analysis was performed on 4929 infants with major defects ascertained by the population-based Metropolitan Atlanta Congenital Defects Program between 1968 and 1980." | 1.28 | Clinical-epidemiologic assessment of pattern of birth defects associated with human teratogens: application to diabetic embryopathy. ( Becerra, JE; Cordero, JF; Erickson, JD; Khoury, MJ, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, DH | 1 |
| Kim, YJ | 1 |
| Chang, SA | 1 |
| Lee, HW | 1 |
| Kim, HN | 1 |
| Kim, HK | 1 |
| Chang, HJ | 1 |
| Sohn, DW | 1 |
| Park, YB | 1 |
| Pitini, V | 1 |
| Arrigo, C | 1 |
| Aloi, G | 1 |
| Azzarello, D | 1 |
| La Gattuta, G | 1 |
| Lueprasitsakul, W | 1 |
| Abend, S | 1 |
| Alex, S | 1 |
| Reinhardt, W | 1 |
| Appel, MC | 1 |
| Braverman, LE | 1 |
| Khoury, MJ | 1 |
| Becerra, JE | 1 |
| Cordero, JF | 1 |
| Erickson, JD | 1 |
4 other studies available for thalidomide and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
The protective effect of thalidomide on left ventricular function in a rat model of diabetic cardiomyopathy.
Topics: Analysis of Variance; Animals; Antibiotics, Antineoplastic; Collagen; Diabetes Mellitus, Type 1; Dia | 2010 |
Diabetic foot disease in a patient with multiple myeloma receiving thalidomide.
Topics: Angiogenesis Inhibitors; Collateral Circulation; Combined Modality Therapy; Diabetes Mellitus, Type | 2002 |
Effect of thalidomide on the incidence of iodine-induced and spontaneous lymphocytic thyroiditis and spontaneous diabetes mellitus in the BB/Wor rat.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Female; Iodine; Male; Rats; Rat | 1990 |
Clinical-epidemiologic assessment of pattern of birth defects associated with human teratogens: application to diabetic embryopathy.
Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Diabetes Mellitus, Type 1; Female; Georgia; H | 1989 |