thalidomide has been researched along with Delayed Effects, Prenatal Exposure in 37 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Of a population of 100 Swedish thalidomide embryopathy cases, at least four met full criteria for DSM-III-R autistic disorder and ICD-10 childhood autism." | 7.69 | Autism in thalidomide embryopathy: a population study. ( Akerström, B; Gillberg, C; Miller, M; Nordin, V; Strömland, K, 1994) |
| "Autism is a behaviorally characterized disorder with impairments in social interactions, as well as stereotyped, repetitive patterns of behaviors and interests." | 5.36 | Nonexploratory movement and behavioral alterations in a thalidomide or valproic acid-induced autism model rat. ( Imura, Y; Kamada, N; Narita, M; Narita, N; Oyabu, A; Tano, K; Uchida, A; Yokoyama, T, 2010) |
| "The pregnancy was complicated by dialysis difficulties, uncontrollable hypertension and deteriorating renal function resulting in fetal loss at 26-weeks' gestation." | 5.28 | Thalidomide, pregnancy and renal failure. ( Brown, MA; Child, RP; Farrell, C; Newton, P, 1990) |
| "One third of Swedes with thalidomide embryopathy have sixth and seventh cranial nerve palsy, named Möbius syndrome/sequence, and some of them suffer from autism." | 4.80 | [Eye muscle paralysis can increase the knowledge on autism]. ( Strömland, K, 2000) |
| "Fifty years ago several thousand children were born with severe limb defects after their mothers had been given thalidomide in pregnancy." | 3.78 | The penumbra of thalidomide, the litigation culture and the licensing of pharmaceuticals. ( Lachmann, PJ, 2012) |
| "Based on the fact that thalidomide, at a certain point in human pregnancy, produces autism, we propose administering thalidomide to pregnant monkeys at an appropriate point after conception." | 3.72 | A proposed primate animal model of autism. ( Teitelbaum, P, 2003) |
| "Of a population of 100 Swedish thalidomide embryopathy cases, at least four met full criteria for DSM-III-R autistic disorder and ICD-10 childhood autism." | 3.69 | Autism in thalidomide embryopathy: a population study. ( Akerström, B; Gillberg, C; Miller, M; Nordin, V; Strömland, K, 1994) |
| "Thalidomide was marketed for the treatment of morning sickness and resulted in foetal death and physical deformities." | 1.39 | Late-onset neurological symptoms in thalidomide-exposed subjects: a study of an Australasian cohort. ( Burke, D; Jankelowitz, SK; Spies, JM, 2013) |
| "Autism is a behaviorally characterized disorder with impairments in social interactions, as well as stereotyped, repetitive patterns of behaviors and interests." | 1.36 | Nonexploratory movement and behavioral alterations in a thalidomide or valproic acid-induced autism model rat. ( Imura, Y; Kamada, N; Narita, M; Narita, N; Oyabu, A; Tano, K; Uchida, A; Yokoyama, T, 2010) |
| "Thalidomide was withdrawn from the market in the early sixties because of major teratogenic effects such as reduction defects of the limbs." | 1.30 | [Thalidomide once more in the spotlight]. ( Cornel, MC; de Jong-van den Berg, LT; Rutgers, J, 1998) |
| "The pregnancy was complicated by dialysis difficulties, uncontrollable hypertension and deteriorating renal function resulting in fetal loss at 26-weeks' gestation." | 1.28 | Thalidomide, pregnancy and renal failure. ( Brown, MA; Child, RP; Farrell, C; Newton, P, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (35.14) | 18.7374 |
| 1990's | 8 (21.62) | 18.2507 |
| 2000's | 6 (16.22) | 29.6817 |
| 2010's | 10 (27.03) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Samel, C | 1 |
| Albus, C | 1 |
| Tebest, R | 1 |
| Forster, K | 1 |
| Lüngen, M | 1 |
| Niecke, A | 1 |
| Pfaff, H | 1 |
| Peters, KM | 1 |
| Imanishi, S | 1 |
| Okura, M | 1 |
| Zaha, H | 1 |
| Yamamoto, T | 1 |
| Akanuma, H | 1 |
| Nagano, R | 1 |
| Shiraishi, H | 1 |
| Fujimaki, H | 1 |
| Sone, H | 1 |
| Rowe, T | 1 |
| Tajima, T | 1 |
| Wada, T | 1 |
| Yoshizawa, A | 1 |
| Masuda, T | 1 |
| Okafuji, T | 1 |
| Nakayama, T | 1 |
| Hasuo, K | 1 |
| Hou, JK | 1 |
| Mahadevan, U | 1 |
| Narita, M | 1 |
| Oyabu, A | 1 |
| Imura, Y | 1 |
| Kamada, N | 1 |
| Yokoyama, T | 1 |
| Tano, K | 1 |
| Uchida, A | 1 |
| Narita, N | 1 |
| O'Carroll, A | 1 |
| O'Reilly, F | 1 |
| Whitford, DL | 1 |
| Ahmed, F | 1 |
| Sharif, MO | 1 |
| Yart, R | 1 |
| Hussain, KG | 1 |
| Richmond, R | 1 |
| Lachmann, PJ | 1 |
| Nau, JY | 1 |
| Jankelowitz, SK | 1 |
| Spies, JM | 1 |
| Burke, D | 1 |
| Strömland, K | 3 |
| Philipson, E | 1 |
| Andersson Grönlund, M | 1 |
| Teitelbaum, P | 1 |
| HIRSCH, W | 1 |
| MONIE, IW | 1 |
| KISTNER, RW | 1 |
| PAPST, W | 1 |
| SCHMIDT, JG | 1 |
| OTTO, J | 1 |
| HONEGGER, H | 1 |
| PAPE, R | 1 |
| GOERTTLER, K | 1 |
| Kohlhase, J | 1 |
| Holmes, LB | 1 |
| Hallene, KL | 1 |
| Oby, E | 1 |
| Lee, BJ | 1 |
| Santaguida, S | 1 |
| Bassanini, S | 1 |
| Cipolla, M | 1 |
| Marchi, N | 1 |
| Hossain, M | 1 |
| Battaglia, G | 1 |
| Janigro, D | 1 |
| Bertoli, D | 1 |
| Borelli, G | 1 |
| Tenconi, R | 1 |
| Clementi, M | 1 |
| Notari, L | 1 |
| Lo Vasco, VR | 1 |
| Nordin, V | 1 |
| Miller, M | 1 |
| Akerström, B | 1 |
| Gillberg, C | 1 |
| Jacobsson, C | 1 |
| Granström, G | 1 |
| Smithells, D | 1 |
| de Jong-van den Berg, LT | 1 |
| Rutgers, J | 1 |
| Cornel, MC | 1 |
| Roper, J | 1 |
| Fieldston, E | 1 |
| Teff, H | 1 |
| Munro, C | 1 |
| Miller, MT | 1 |
| Brown, MA | 1 |
| Farrell, C | 1 |
| Newton, P | 1 |
| Child, RP | 1 |
| Kanno, O | 1 |
| Newman, CG | 1 |
2 reviews available for thalidomide and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
[ETIOPATHOGENESIS OF DEVELOPMENTAL DISORDERS. EXPERIMENTAL CONTRIBUTION TO THE CONCEPT OF PHENOCOPY].
Topics: Animals; Antimetabolites; Avitaminosis; Congenital Abnormalities; Hypoxia; Mammals; Pregnancy; Pregn | 1964 |
[Eye muscle paralysis can increase the knowledge on autism].
Topics: Abnormalities, Multiple; Adult; Animals; Autistic Disorder; Facial Nerve; Female; Humans; Hypnotics | 2000 |
35 other studies available for thalidomide and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
[Upcoming challenges in providing care for thalidomide impaired individuals].
Topics: Child; Cross-Sectional Studies; Female; Germany; Humans; Pregnancy; Prenatal Exposure Delayed Effect | 2019 |
Prenatal exposure to permethrin influences vascular development of fetal brain and adult behavior in mice offspring.
Topics: Angiogenesis Inhibitors; Animals; Animals, Newborn; Brain; Cerebral Arteries; Dopamine; Female; Fetu | 2013 |
Drugs in Pregnancy.
Topics: Female; History, 20th Century; Humans; Pharmaceutical Preparations; Pregnancy; Prenatal Exposure Del | 2015 |
Internal anomalies in thalidomide embryopathy: results of imaging screening by CT and MRI.
Topics: Abnormalities, Multiple; Causality; Female; Gallbladder; Humans; Japan; Liver; Magnetic Resonance Im | 2016 |
A 24-year-old pregnant woman with inflammatory bowel disease.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Breast Feeding; Crohn Disease; Female; Fetus; Huma | 2009 |
Nonexploratory movement and behavioral alterations in a thalidomide or valproic acid-induced autism model rat.
Topics: Age Factors; Animals; Autistic Disorder; Disease Models, Animal; Exploratory Behavior; Female; Inter | 2010 |
What has happened to people affected by thalidomide 50 years on?
Topics: Activities of Daily Living; Adult; Arm; Disabled Persons; Female; Health Status; Humans; Leg; Male; | 2011 |
Adaptive toothbrush handle: case report of a Thalidomide patient.
Topics: Dental Devices, Home Care; Dental Plaque Index; Ectromelia; Equipment Design; Female; Humans; Male; | 2012 |
The penumbra of thalidomide, the litigation culture and the licensing of pharmaceuticals.
Topics: Abnormalities, Drug-Induced; Animals; Child; Drug Costs; Female; Humans; Jurisprudence; Licensure; M | 2012 |
[Thalidomide: this "mea culpa" which isn't one].
Topics: Child, Preschool; Dissent and Disputes; Drug Industry; Female; Germany; Humans; Jurisprudence; Limb | 2012 |
Late-onset neurological symptoms in thalidomide-exposed subjects: a study of an Australasian cohort.
Topics: Antiemetics; Australasia; Australia; Cohort Studies; Disease Progression; Female; Humans; Male; Midd | 2013 |
Offspring of male and female parents with thalidomide embryopathy: birth defects and functional anomalies.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Child; Child, Preschool; Congenital Abnormalities; F | 2002 |
A proposed primate animal model of autism.
Topics: Animals; Animals, Newborn; Autistic Disorder; Child; Disease Models, Animal; Female; Haplorhini; Hum | 2003 |
Phocomelia.
Topics: Congenital Abnormalities; Ectromelia; Humans; Learning; Metabolic Diseases; Prenatal Exposure Delaye | 1963 |
INFLUENCE OF THE ENVIRONMENT ON THE UNBORN.
Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Communicable Diseases; Congenital Abnormalities; | 1963 |
HAZARDS OF OBSTETRICAL AND GYNECOLOGICAL DRUGS.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Androgens; Drug Therapy; Estrogens; Female; Gy | 1964 |
[THALIDOMIDE AND CONGENITAL ABNORMALITIES OF THE EYE].
Topics: Abnormalities, Drug-Induced; Anophthalmos; Child; Eye Diseases; Infant; Learning; Microphthalmos; Op | 1964 |
[OCULOMOTOR PARALYSIS IN THALIDOMIDE EMBRYOPATHY].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Female; Fetal Diseases; Ophthalmoplegia | 1964 |
[CONTERGAN INJURY WITH EYE INVOLVEMENT].
Topics: Abnormalities, Drug-Induced; Child; Eye Diseases; Female; Learning; Microphthalmos; Pregnancy; Prena | 1964 |
[THALIDOMIDE AND CONGENITAL ABNORMALITIES OF THE EYE].
Topics: Abnormalities, Drug-Induced; Child; Eye Diseases; Female; Learning; Microphthalmos; Pregnancy; Prena | 1964 |
Mutations in SALL4 in malformed father and daughter postulated previously due to reflect mutagenesis by thalidomide.
Topics: Duane Retraction Syndrome; Fathers; Female; Hearing Loss; Humans; Male; Mutation; Pregnancy; Prenata | 2004 |
Prenatal exposure to thalidomide, altered vasculogenesis, and CNS malformations.
Topics: Action Potentials; Animals; Animals, Newborn; Aorta; Blotting, Western; Cattle; Central Nervous Syst | 2006 |
[Teratogenic action of Rifaximin in the rat and rabbit and its effect on perinatal development in the rat].
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetus; Hydroxyurea; Pregnancy; Prenatal Exposure Delay | 1984 |
Amniotic band sequence in child of thalidomide victim.
Topics: Amniotic Band Syndrome; Female; Hand Deformities, Congenital; Humans; Infant, Newborn; Limb Deformit | 1994 |
Autism in thalidomide embryopathy: a population study.
Topics: Adult; Autistic Disorder; Deafness; Female; Humans; Intellectual Disability; Male; Pregnancy; Prenat | 1994 |
Clinical appearance of spontaneous and induced first and second branchial arch syndromes.
Topics: Adult; Animals; Branchial Region; Craniofacial Dysostosis; Disease Models, Animal; Facial Asymmetry; | 1997 |
Does thalidomide cause second generation birth defects?
Topics: Abnormalities, Drug-Induced; Female; Humans; Pregnancy; Prenatal Exposure Delayed Effects; Thalidomi | 1998 |
[Thalidomide once more in the spotlight].
Topics: Adult; Bone Marrow Transplantation; Contraindications; Drug and Narcotic Control; Drug Approval; Fem | 1998 |
Full compensation for 20 thalidomide victims.
Topics: Child; Compensation and Redress; Disabled Persons; Drug Industry; Economics; Humans; Parents; Pharma | 1978 |
AIDS, thalidomide and maternal-fetal rights in conflict.
Topics: Abortion, Eugenic; Acquired Immunodeficiency Syndrome; Coercion; Contraception; Drug-Related Side Ef | 1998 |
Who pays for drug-induced injuries?
Topics: Compensation and Redress; Economics; Government Regulation; Humans; Industry; Liability, Legal; Malp | 1976 |
Ocular teratology. Observations, speculations, questions, principles reaffirmed.
Topics: Ethanol; Eye; Eye Abnormalities; Female; Gestational Age; Humans; Pregnancy; Prenatal Exposure Delay | 1992 |
Thalidomide, pregnancy and renal failure.
Topics: Adult; Antihypertensive Agents; Combined Modality Therapy; Female; Humans; Hypertension; Kidney Fail | 1990 |
Electroencephalographic study of 137 patients with thalidomide embryopathy.
Topics: Adolescent; Adult; Brain; Child; Electroencephalography; Epilepsy; Female; Fetal Diseases; Hearing D | 1987 |
Teratogen update: clinical aspects of thalidomide embryopathy--a continuing preoccupation.
Topics: Abdomen; Abnormalities, Multiple; Cardiovascular Abnormalities; Cranial Nerves; Dentition; Embryo, M | 1985 |