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thalidomide and Craniofacial Abnormalities

thalidomide has been researched along with Craniofacial Abnormalities in 5 studies

Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.

Craniofacial Abnormalities: Congenital structural deformities, malformations, or other abnormalities of the cranium and facial bones.

Research Excerpts

ExcerptRelevanceReference
"Thalidomide is widely used for several diseases; however, it causes malformations in embryos exposed during pregnancy."7.91The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis. ( Fraga, LR; Gomes, JDA; Kowalski, TW; Macedo, GS; Sanseverino, MTV; Schuler-Faccini, L; Vianna, FSL, 2019)
"Thalidomide is widely used for several diseases; however, it causes malformations in embryos exposed during pregnancy."3.91The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis. ( Fraga, LR; Gomes, JDA; Kowalski, TW; Macedo, GS; Sanseverino, MTV; Schuler-Faccini, L; Vianna, FSL, 2019)
"Cranial nerve palsy/paresis was only seen in HFM and thalidomide-induced malformations."1.30Teratological studies on craniofacial malformations. ( Jacobsson, C, 1997)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's2 (40.00)24.3611
2020's2 (40.00)2.80

Authors

AuthorsStudies
Sanchez, AC1
Thren, ED1
Iovine, MK1
Skibbens, RV1
Zhao, Y1
Chen, Q1
Chen, L1
Shen, SGF1
Dai, J1
Gomes, JDA1
Kowalski, TW1
Fraga, LR1
Macedo, GS1
Sanseverino, MTV1
Schuler-Faccini, L1
Vianna, FSL1
Lyon, J1
Jacobsson, C1

Other Studies

5 other studies available for thalidomide and Craniofacial Abnormalities

ArticleYear
Esco2 and cohesin regulate CRL4 ubiquitin ligase
    Cell cycle (Georgetown, Tex.), 2022, Volume: 21, Issue:5

    Topics: Acetyltransferases; Cell Cycle Proteins; Chromosomal Proteins, Non-Histone; Cohesins; Craniofacial A

2022
Thalidomide leads to mandible hypoplasia through inhibiting angiogenesis and secondary hemorrhage in the fetal craniofacial region in rabbits.
    Toxicology letters, 2020, Feb-01, Volume: 319

    Topics: Animals; Craniofacial Abnormalities; Down-Regulation; Female; Hemorrhage; Mandible; Maxillofacial Ab

2020
The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis.
    Scientific reports, 2019, 08-06, Volume: 9, Issue:1

    Topics: Abnormalities, Multiple; Acetyltransferases; Brazil; Cell Line; Chromosomal Proteins, Non-Histone; C

2019
Zika: Worse Than Thalidomide?
    JAMA, 2016, Sep-27, Volume: 316, Issue:12

    Topics: Adult; Caribbean Region; Craniofacial Abnormalities; Female; Humans; Outcome Assessment, Health Care

2016
Teratological studies on craniofacial malformations.
    Swedish dental journal. Supplement, 1997, Volume: 121

    Topics: Alkaline Phosphatase; Aminopropionitrile; Amniotic Fluid; Animals; Branchial Region; Cartilage; Clef

1997