thalidomide has been researched along with Craniofacial Abnormalities in 5 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Craniofacial Abnormalities: Congenital structural deformities, malformations, or other abnormalities of the cranium and facial bones.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thalidomide is widely used for several diseases; however, it causes malformations in embryos exposed during pregnancy." | 7.91 | The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis. ( Fraga, LR; Gomes, JDA; Kowalski, TW; Macedo, GS; Sanseverino, MTV; Schuler-Faccini, L; Vianna, FSL, 2019) |
| "Thalidomide is widely used for several diseases; however, it causes malformations in embryos exposed during pregnancy." | 3.91 | The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis. ( Fraga, LR; Gomes, JDA; Kowalski, TW; Macedo, GS; Sanseverino, MTV; Schuler-Faccini, L; Vianna, FSL, 2019) |
| "Cranial nerve palsy/paresis was only seen in HFM and thalidomide-induced malformations." | 1.30 | Teratological studies on craniofacial malformations. ( Jacobsson, C, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sanchez, AC | 1 |
| Thren, ED | 1 |
| Iovine, MK | 1 |
| Skibbens, RV | 1 |
| Zhao, Y | 1 |
| Chen, Q | 1 |
| Chen, L | 1 |
| Shen, SGF | 1 |
| Dai, J | 1 |
| Gomes, JDA | 1 |
| Kowalski, TW | 1 |
| Fraga, LR | 1 |
| Macedo, GS | 1 |
| Sanseverino, MTV | 1 |
| Schuler-Faccini, L | 1 |
| Vianna, FSL | 1 |
| Lyon, J | 1 |
| Jacobsson, C | 1 |
5 other studies available for thalidomide and Craniofacial Abnormalities
| Article | Year |
|---|---|
Esco2 and cohesin regulate CRL4 ubiquitin ligase
Topics: Acetyltransferases; Cell Cycle Proteins; Chromosomal Proteins, Non-Histone; Cohesins; Craniofacial A | 2022 |
Thalidomide leads to mandible hypoplasia through inhibiting angiogenesis and secondary hemorrhage in the fetal craniofacial region in rabbits.
Topics: Animals; Craniofacial Abnormalities; Down-Regulation; Female; Hemorrhage; Mandible; Maxillofacial Ab | 2020 |
The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis.
Topics: Abnormalities, Multiple; Acetyltransferases; Brazil; Cell Line; Chromosomal Proteins, Non-Histone; C | 2019 |
Zika: Worse Than Thalidomide?
Topics: Adult; Caribbean Region; Craniofacial Abnormalities; Female; Humans; Outcome Assessment, Health Care | 2016 |
Teratological studies on craniofacial malformations.
Topics: Alkaline Phosphatase; Aminopropionitrile; Amniotic Fluid; Animals; Branchial Region; Cartilage; Clef | 1997 |