thalidomide has been researched along with Constriction, Pathologic in 5 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Constriction, Pathologic: The condition of an anatomical structure's being constricted beyond normal dimensions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the study was to evaluate thalidomide as rescue therapy for pediatric patients with severe refractory Crohn disease (CD) who failed to respond to antitumor necrosis factor (TNF) biologic agents." | 7.78 | Thalidomide use and outcomes in pediatric patients with Crohn disease refractory to infliximab and adalimumab. ( Felipez, LM; Gokhale, R; Kirschner, BS; Tierney, MP, 2012) |
| "The aim of the study was to evaluate thalidomide as rescue therapy for pediatric patients with severe refractory Crohn disease (CD) who failed to respond to antitumor necrosis factor (TNF) biologic agents." | 3.78 | Thalidomide use and outcomes in pediatric patients with Crohn disease refractory to infliximab and adalimumab. ( Felipez, LM; Gokhale, R; Kirschner, BS; Tierney, MP, 2012) |
| "Thalidomide was used as a sedative drug for pregnant women in the 1950-60:s and resulted in children born with thalidomide embryopathy (TE), including upper limb malformations." | 1.43 | Degenerative Changes in the Cervical Spine Are More Common in Middle-Aged Individuals with Thalidomide Embryopathy than in Healthy Controls. ( Ab-Fawaz, R; Brisby, H; Danielson, B; Danielsson, A; Ghassemi Jahani, SA; Hebelka, H, 2016) |
| "The GENetic DEterminants of Restenosis (GENDER) project included 3104 patients who underwent a successful PCI." | 1.33 | Tumor necrosis factor-alpha plays an important role in restenosis development. ( 't Hart, LM; Agema, WR; Boesten, LS; de Maat, MP; de Vries, MR; de Winter, RJ; Doevendans, PA; Frants, RR; Havekes, LM; Jukema, JW; Monraats, PS; Pires, NM; Quax, PH; Schepers, A; Tio, RA; van der Laarse, A; van der Wall, EE; van Vlijmen, BJ; Waltenberger, J; Zwinderman, AH, 2005) |
| "In experiment 1, rats with the neuritis but not those with the myositis developed neuropathic pain symptoms." | 1.31 | A neuroimmune interaction in painful peripheral neuropathy. ( Bennett, GJ, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mamopoulos, A | 1 |
| Nowak, T | 1 |
| Luther, B | 1 |
| Ghassemi Jahani, SA | 1 |
| Danielsson, A | 1 |
| Ab-Fawaz, R | 1 |
| Hebelka, H | 1 |
| Danielson, B | 1 |
| Brisby, H | 1 |
| Felipez, LM | 1 |
| Gokhale, R | 1 |
| Tierney, MP | 1 |
| Kirschner, BS | 1 |
| Monraats, PS | 1 |
| Pires, NM | 1 |
| Schepers, A | 1 |
| Agema, WR | 1 |
| Boesten, LS | 1 |
| de Vries, MR | 1 |
| Zwinderman, AH | 1 |
| de Maat, MP | 1 |
| Doevendans, PA | 1 |
| de Winter, RJ | 1 |
| Tio, RA | 1 |
| Waltenberger, J | 1 |
| 't Hart, LM | 1 |
| Frants, RR | 1 |
| Quax, PH | 1 |
| van Vlijmen, BJ | 1 |
| Havekes, LM | 1 |
| van der Laarse, A | 1 |
| van der Wall, EE | 1 |
| Jukema, JW | 1 |
| Bennett, GJ | 1 |
5 other studies available for thalidomide and Constriction, Pathologic
| Article | Year |
|---|---|
Peripheral arterial reconstruction in a patient with thalidomide embryopathy and chronic occlusion of the femoral artery.
Topics: Abnormalities, Drug-Induced; Antiemetics; Arterial Occlusive Diseases; Chronic Disease; Constriction | 2013 |
Degenerative Changes in the Cervical Spine Are More Common in Middle-Aged Individuals with Thalidomide Embryopathy than in Healthy Controls.
Topics: Adult; Case-Control Studies; Cervical Vertebrae; Constriction, Pathologic; Demography; Female; Fetal | 2016 |
Thalidomide use and outcomes in pediatric patients with Crohn disease refractory to infliximab and adalimumab.
Topics: Adalimumab; Adolescent; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Hu | 2012 |
Tumor necrosis factor-alpha plays an important role in restenosis development.
Topics: Aged; Alleles; Angina Pectoris; Angiography; Angioplasty, Balloon, Coronary; Animals; Constriction, | 2005 |
A neuroimmune interaction in painful peripheral neuropathy.
Topics: Animals; Constriction, Pathologic; Cyclosporine; Dose-Response Relationship, Drug; Immunosuppressive | 2000 |