thalidomide and Congenital Oculofacial Paralysis, Moebius studies

Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.

Research Excerpts

Excerpt	Relevance	Reference
"One third of Swedes with thalidomide embryopathy have sixth and seventh cranial nerve palsy, named Möbius syndrome/sequence, and some of them suffer from autism."	4.80	[Eye muscle paralysis can increase the knowledge on autism]. ( Strömland, K, 2000)
"To review the association of autism spectrum disorder (ASD) in individuals manifesting thalidomide embryopathy and Möbius sequence and compare them with three new studies in which ASD was also associated with ocular and systemic malformations: (1) a Swedish study of individuals with CHARGE association (Coloboma, Heart, choanal Atresia, developmental or growth Retardation, Genital anomaly, and Ear involvement); (2) a Swedish study of Goldenhar syndrome; and (3) Brazilian Möbius syndrome (sequence) study."	3.72	Autism with ophthalmologic malformations: the plot thickens. ( Bandim, JM; Gillberg, C; Johansson, M; Miller, MT; Strömland, K; Ventura, L, 2004)
"We found that Duane syndrome and its variants were prominent in individuals who were exposed to thalidomide early in the sensitive period (days 20 to 26±)."	2.47	What can we learn from the thalidomide experience: an ophthalmologic perspective. ( Miller, MT; Strömland, KK, 2011)
"Thalidomide is a very potent teratogen capable of causing severe systemic malformations if the fetus is exposed during the sensitive period."	2.45	Thalidomide and misoprostol: Ophthalmologic manifestations and associations both expected and unexpected. ( Miller, MT; Strömland, K; Ventura, L, 2009)
"Most reported cases are associated with Duane syndrome."	2.44	Congenital aberrant tearing: a re-look. ( Miller, MT; Strömland, K; Ventura, L, 2008)

Research

Studies (5)

Authors

Reviews

4 reviews available for thalidomide and Congenital Oculofacial Paralysis, Moebius

Other Studies

1 other study available for thalidomide and Congenital Oculofacial Paralysis, Moebius

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (80.00)	29.6817
2010's	1 (20.00)	24.3611
2020's	0 (0.00)	2.80

Article	Year
Congenital aberrant tearing: a re-look. Transactions of the American Ophthalmological Society, 2008, Volume: 106 Topics: Abnormalities, Drug-Induced; Duane Retraction Syndrome; Eye Abnormalities; Female; Humans; Lacrimal	2008
Thalidomide and misoprostol: Ophthalmologic manifestations and associations both expected and unexpected. Birth defects research. Part A, Clinical and molecular teratology, 2009, Volume: 85, Issue:8 Topics: Abnormalities, Drug-Induced; Adult; Autistic Disorder; Child; Child, Preschool; Cranial Nerves; Embr	2009
What can we learn from the thalidomide experience: an ophthalmologic perspective. Current opinion in ophthalmology, 2011, Volume: 22, Issue:5 Topics: Abnormalities, Drug-Induced; Duane Retraction Syndrome; Eye Abnormalities; Female; Humans; Limb Defo	2011
[Eye muscle paralysis can increase the knowledge on autism]. Lakartidningen, 2000, Nov-08, Volume: 97, Issue:45 Topics: Abnormalities, Multiple; Adult; Animals; Autistic Disorder; Facial Nerve; Female; Humans; Hypnotics	2000

Authors	Studies
Miller, MT	4
Strömland, K	4
Ventura, L	3
Strömland, KK	1
Johansson, M	1
Bandim, JM	1
Gillberg, C	1