thalidomide has been researched along with Congenital Limb Deformities in 102 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thalidomide is a powerful treatment for inflammatory and cancer-based diseases." | 6.47 | Apoptosis induction by thalidomide: critical for limb teratogenicity but therapeutic potential in idiopathic pulmonary fibrosis? ( Jungck, D; Knobloch, J; Koch, A, 2011) |
| "Thalidomide embryopathy results from the ingestion of thalidomide in the first trimester during pregnancy, causing multiple forms of congenital abnormalities of variable severity that involve all systems." | 5.01 | A clinical review and introduction of the diagnostic algorithm for thalidomide embryopathy (DATE). ( Baple, E; Hall, CM; Mansour, S, 2019) |
| "Thalidomide is a known sensory neurotoxin in adults." | 2.61 | Thalidomide and neurotrophism. ( Bonar, SF; McCredie, J; O'Sullivan, DJ; Soper, JR; Willert, HG, 2019) |
| "Thalidomide is a teratogen that affects many organs but primarily induces limb truncations like phocomelia." | 2.55 | The Molecular Mechanisms of Thalidomide Teratogenicity and Implications for Modern Medicine. ( Jungck, D; Knobloch, J; Koch, A, 2017) |
| "Thalidomide was originally developed in 1954 as a sedative that was commonly used to ameliorate morning sickness." | 2.48 | Deciphering the mystery of thalidomide teratogenicity. ( Handa, H; Ito, T, 2012) |
| "Thalidomide is a powerful treatment for inflammatory and cancer-based diseases." | 2.47 | Apoptosis induction by thalidomide: critical for limb teratogenicity but therapeutic potential in idiopathic pulmonary fibrosis? ( Jungck, D; Knobloch, J; Koch, A, 2011) |
| "We found that Duane syndrome and its variants were prominent in individuals who were exposed to thalidomide early in the sensitive period (days 20 to 26±)." | 2.47 | What can we learn from the thalidomide experience: an ophthalmologic perspective. ( Miller, MT; Strömland, KK, 2011) |
| "For a baby with bilateral lower phocomelia, a special "sitting socket" was devised to enable sitting in an upright position." | 2.36 | Review of the treatment of thalidomide children with limb defeciency in Great Britain. ( Fletcher, I, 1980) |
| "Thalidomide is a known teratogen and it is estimated that more than ten thousand babies were affected by thalidomide embryopathy (TE), which is characterized mainly by limb defects, but can involve many organs and systems." | 1.42 | Thalidomide embryopathy: Follow-up of cases born between 1959 and 2010. ( Kowalski, TW; Sanseverino, MT; Schuler-Faccini, L; Vianna, FS, 2015) |
| "Thalidomide is a potent teratogen that induces a range of birth defects, most commonly of the developing limbs." | 1.35 | Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation. ( Erskine, L; Figg, WD; Gardner, ER; Therapontos, C; Vargesson, N, 2009) |
| "Thalidomide has a potent immunomodulatory property and has now a number of approved and off-label uses in dermatologic, oncologic, infectious and gastrointestinal conditions." | 1.34 | New cases of thalidomide embryopathy in Brazil. ( Castilla, EE; de Sousa, AC; Luna, E; Maximino, C; Schuler-Faccini, L; Schwartz, IV; Soares, RC; Waldman, C, 2007) |
| "The present study determined effects of thalidomide on three successive generations of New Zealand White rabbits after oral dosing to F0 maternal rabbits during the later third of gestation (post major organogenesis) and lactation." | 1.32 | Effects of thalidomide on developmental, peri- and postnatal function in female New Zealand white rabbits and offspring. ( Denny, KH; Hoberman, AM; Morseth, S; Stirling, DI; Teo, SK; Thomas, SD, 2004) |
| "Cases with documented maternal alcohol abuse in pregnancy in this group were analyzed separately." | 1.28 | Congenital defects of the limbs and alcohol exposure in pregnancy: data from a population based study. ( Baird, PA; Froster, UG, 1992) |
| "Thalidomide was administered to pregnant rabbits in dosages of 150-250 mg/kg/day on days 8-12 of gestation." | 1.26 | Studies of the etiology of thalidomide dysmorphogenesis. ( McBride, WG, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 59 (57.84) | 18.7374 |
| 1990's | 15 (14.71) | 18.2507 |
| 2000's | 12 (11.76) | 29.6817 |
| 2010's | 15 (14.71) | 24.3611 |
| 2020's | 1 (0.98) | 2.80 |
| Authors | Studies |
|---|---|
| Belair, DG | 1 |
| Lu, G | 1 |
| Waller, LE | 1 |
| Gustin, JA | 1 |
| Collins, ND | 1 |
| Kolaja, KL | 1 |
| Knobloch, J | 4 |
| Jungck, D | 2 |
| Koch, A | 2 |
| Mahony, C | 1 |
| McMenemy, S | 1 |
| Rafipay, AJ | 1 |
| Beedie, SL | 1 |
| Fraga, LR | 1 |
| Gütschow, M | 1 |
| Figg, WD | 2 |
| Erskine, L | 2 |
| Vargesson, N | 4 |
| Rodríguez-Pérez, F | 1 |
| Rape, M | 1 |
| Mansour, S | 1 |
| Baple, E | 1 |
| Hall, CM | 1 |
| Soper, JR | 1 |
| Bonar, SF | 1 |
| O'Sullivan, DJ | 1 |
| McCredie, J | 11 |
| Willert, HG | 3 |
| PETERSEN, CE | 1 |
| Kowalski, TW | 1 |
| Sanseverino, MT | 1 |
| Schuler-Faccini, L | 2 |
| Vianna, FS | 1 |
| Ekfeldt, A | 1 |
| Carlsson, GE | 1 |
| Stoeckel, MC | 1 |
| Seitz, RJ | 1 |
| Buetefisch, CM | 1 |
| Therapontos, C | 1 |
| Gardner, ER | 1 |
| Stephens, TD | 3 |
| Ema, M | 1 |
| Ise, R | 1 |
| Kato, H | 1 |
| Oneda, S | 1 |
| Hirose, A | 1 |
| Hirata-Koizumi, M | 1 |
| Singh, AV | 1 |
| Knudsen, TB | 1 |
| Ihara, T | 1 |
| Miller, MT | 2 |
| Strömland, KK | 1 |
| Ito, T | 1 |
| Handa, H | 1 |
| Brent, R | 1 |
| Nau, JY | 1 |
| Fraser, C | 1 |
| Sípek, A | 2 |
| Maňáková, E | 1 |
| Holmes, LB | 2 |
| BUKIET, V | 1 |
| FRANKLIN, AW | 2 |
| GILLIS, L | 1 |
| VESTERGARD, S | 1 |
| HALL, JE | 1 |
| WARD, SP | 1 |
| GINGRAS, G | 1 |
| MONGEAU, M | 1 |
| MOREAULT, P | 1 |
| DUPUIS, M | 1 |
| HEBERT, B | 1 |
| CORRIVEAU, C | 1 |
| KENEZ, J | 1 |
| LENZ, W | 1 |
| KNAPP, K | 1 |
| MOL, W | 1 |
| Hansen, JM | 1 |
| Harris, C | 1 |
| Teo, SK | 1 |
| Denny, KH | 1 |
| Stirling, DI | 1 |
| Thomas, SD | 1 |
| Morseth, S | 1 |
| Hoberman, AM | 1 |
| Johnson, M | 1 |
| Soares, RC | 1 |
| de Sousa, AC | 1 |
| Maximino, C | 1 |
| Luna, E | 1 |
| Schwartz, IV | 1 |
| Waldman, C | 1 |
| Castilla, EE | 1 |
| Schmitz, I | 1 |
| Götz, K | 1 |
| Schulze-Osthoff, K | 1 |
| Rüther, U | 2 |
| Vickers, TH | 2 |
| Freire-Maia, N | 1 |
| Freire-Maia, A | 1 |
| Neubert, D | 2 |
| Krowke, R | 1 |
| North, K | 1 |
| de Iongh, R | 1 |
| Strecker, TR | 1 |
| Schmidt, M | 1 |
| Salzano, FM | 1 |
| Källén, B | 1 |
| Rahmani, TM | 1 |
| Winberg, J | 2 |
| Fletcher, I | 1 |
| Tenconi, R | 1 |
| Clementi, M | 1 |
| Notari, L | 1 |
| Lo Vasco, VR | 1 |
| Bílá, V | 1 |
| Kren, V | 1 |
| McBride, WG | 4 |
| Smith, DM | 1 |
| Torres, RD | 1 |
| Yang, Q | 1 |
| Khoury, MJ | 1 |
| James, LM | 1 |
| Olney, RS | 1 |
| Paulozzi, LJ | 1 |
| Erickson, JD | 1 |
| Holliday, R | 1 |
| McGuirk, CK | 1 |
| Stoler, JM | 1 |
| Lieberman, E | 1 |
| Parman, T | 1 |
| Wiley, MJ | 1 |
| Wells, PG | 1 |
| Guenzler, V | 1 |
| Strömland, K | 1 |
| Hendrickx, AG | 1 |
| Sawyer, RH | 1 |
| Kochhar, DM | 1 |
| Wolpert, L | 1 |
| Grosse, FR | 1 |
| Wiedemann, H | 1 |
| Loewenthal, J | 1 |
| Newman, CG | 5 |
| Brook, CG | 1 |
| Jarvis, SN | 1 |
| Koch, H | 2 |
| Köhler, F | 1 |
| Smithells, RW | 1 |
| Froster, UG | 1 |
| Baird, PA | 1 |
| Koch, HP | 1 |
| Chamberlain, G | 1 |
| Merker, HJ | 1 |
| Heger, W | 1 |
| Sames, K | 1 |
| Stürje, H | 1 |
| Jäger, M | 1 |
| Refior, HJ | 1 |
| Zenker, H | 1 |
| Stockinger, L | 1 |
| Nichols, PJ | 2 |
| Clarke, MS | 1 |
| McCay, G | 1 |
| Molden, FR | 1 |
| Nudleman, KL | 1 |
| Travill, AA | 1 |
| Hamilton, WJ | 2 |
| Poswillo, DE | 2 |
| Sopher, D | 1 |
| Palmer, AK | 1 |
| Pearn, JH | 1 |
| Fabro, S | 1 |
| Smith, RL | 1 |
| Helm, F | 1 |
| Stanzhevskaia, TI | 1 |
| Vondruska, JF | 1 |
| Fancher, OE | 1 |
| Calandra, JC | 1 |
| Aeppli, L | 1 |
| Kreipe, U | 1 |
| Rogers, EE | 1 |
| Clark, MS | 1 |
| Stamp, WG | 1 |
| Sharrard, WJ | 1 |
| Henkel, L | 1 |
| Sakr, R | 1 |
| el-Zawahry, K | 1 |
| Khalifa, AS | 1 |
| Aboul Hassan, A | 1 |
| Khalil, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| QUIREDEX: A National, Open-Label, Multicenter, Randomized, Phase III Study of Revlimid (Lenalidomide) and Dexamethasone (ReDex) Treatment Versus Observation in Patients With Smoldering Multiple Myeloma With High Risk of Progression[NCT00480363] | Phase 3 | 120 participants (Actual) | Interventional | 2007-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
18 reviews available for thalidomide and Congenital Limb Deformities
| Article | Year |
|---|---|
The Molecular Mechanisms of Thalidomide Teratogenicity and Implications for Modern Medicine.
Topics: Abnormalities, Drug-Induced; Animals; Biomarkers; Female; Gene Expression Regulation; Humans; Limb D | 2017 |
A clinical review and introduction of the diagnostic algorithm for thalidomide embryopathy (DATE).
Topics: Algorithms; Diagnosis, Differential; Female; History, 20th Century; History, 21st Century; Humans; L | 2019 |
The teratogenic effects of thalidomide on limbs.
Topics: Abnormalities, Drug-Induced; Extremities; Female; History, 20th Century; History, 21st Century; Huma | 2019 |
Thalidomide and neurotrophism.
Topics: Abnormalities, Drug-Induced; Extremities; Humans; Infant, Newborn; Limb Deformities, Congenital; Per | 2019 |
Thalidomide-induced limb defects: resolving a 50-year-old puzzle.
Topics: History, 20th Century; History, 21st Century; Humans; Limb Deformities, Congenital; Thalidomide | 2009 |
Apoptosis induction by thalidomide: critical for limb teratogenicity but therapeutic potential in idiopathic pulmonary fibrosis?
Topics: Animals; Apoptosis; Disease Models, Animal; Extremities; Idiopathic Pulmonary Fibrosis; Limb Deformi | 2011 |
What can we learn from the thalidomide experience: an ophthalmologic perspective.
Topics: Abnormalities, Drug-Induced; Duane Retraction Syndrome; Eye Abnormalities; Female; Humans; Limb Defo | 2011 |
Deciphering the mystery of thalidomide teratogenicity.
Topics: Adaptor Proteins, Signal Transducing; Animals; Chick Embryo; Female; Fibroblast Growth Factor 8; Hum | 2012 |
Teratogen-induced limb defects.
Topics: Chorionic Villi Sampling; Female; Humans; Limb Deformities, Congenital; Male; Misoprostol; Phenytoin | 2002 |
Shedding light on an old mystery: thalidomide suppresses survival pathways to induce limb defects.
Topics: Animals; Apoptosis; Cell Survival; Extremities; Gene Expression Regulation, Developmental; Humans; L | 2008 |
Review of the treatment of thalidomide children with limb defeciency in Great Britain.
Topics: Abnormalities, Drug-Induced; Acromion; Arm; Child; Ectromelia; Foot Deformities, Congenital; Humans; | 1980 |
The possibility of epigenetic transmission of defects induced by teratogens.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Humans; Limb Deformities, Congenita | 1998 |
Teratogen update: thalidomide: a review, with a focus on ocular findings and new potential uses.
Topics: Eye Abnormalities; Female; History, 20th Century; HIV Infections; Humans; Infant, Newborn; Leprosy; | 1999 |
Mechanisms of limb development and malformation.
Topics: Abnormalities, Drug-Induced; Animals; Cell Differentiation; Chick Embryo; Extremities; Genetics; Lim | 1976 |
Syndromes with reduction and surplus anomalies of the hand.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Fanconi Syndrome; Female; Fingers; Hand Deform | 1977 |
Pathogenesis of congenital malformations. An hypothesis.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Congenital Abnormalities; Female; Ganglia, Spi | 1978 |
The thalidomide syndrome: risks of exposure and spectrum of malformations.
Topics: Ectromelia; Female; Humans; Infant, Newborn; Limb Deformities, Congenital; Pregnancy; Risk; Teratoge | 1986 |
[Studies in experiment animals and dysmelia syndrome].
Topics: Abnormalities, Drug-Induced; Animals; Anura; Cats; Chickens; Cricetinae; Dogs; Drosophila; Guinea Pi | 1966 |
84 other studies available for thalidomide and Congenital Limb Deformities
| Article | Year |
|---|---|
Thalidomide Inhibits Human iPSC Mesendoderm Differentiation by Modulating CRBN-dependent Degradation of SALL4.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; Cullin Proteins; DNA-Binding Protei | 2020 |
CPS49-induced neurotoxicity does not cause limb patterning anomalies in developing chicken embryos.
Topics: Angiogenesis Inhibitors; Animals; Body Patterning; Bungarotoxins; Chick Embryo; Embryonic Developmen | 2018 |
Unlocking a dark past.
Topics: Humans; Limb Deformities, Congenital; Teratogens; Thalidomide; Transcription Factors | 2018 |
[Thalidomide and malformations. Contribution to the problem of the etiology of a frequently occurring malformation complex].
Topics: Congenital Abnormalities; Extremities; Hypnotics and Sedatives; Limb Deformities, Congenital; Thalid | 1962 |
Thalidomide embryopathy: Follow-up of cases born between 1959 and 2010.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Adult; Brazil; Child, Preschool; F | 2015 |
Dental status and oral function in an adult group of subjects with thalidomide embryopathy - a clinical and questionnaire study.
Topics: Abnormalities, Drug-Induced; Anodontia; Dental Care for Disabled; Dental Caries; DMF Index; Female; | 2008 |
Congenitally altered motor experience alters somatotopic organization of human primary motor cortex.
Topics: Adult; Brain Mapping; Case-Control Studies; Evoked Potentials, Motor; Female; Humans; Limb Deformiti | 2009 |
Thalidomide induces limb defects by preventing angiogenic outgrowth during early limb formation.
Topics: Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Chick Embryo; Cytoskeleton; Humans; Inflamm | 2009 |
The effect of thalidomide in chicken embryos.
Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Dose-Response Relationship, Drug; Extremities; L | 2009 |
Fetal malformations and early embryonic gene expression response in cynomolgus monkeys maternally exposed to thalidomide.
Topics: Abnormalities, Drug-Induced; Animals; Female; Gene Expression; Gene Expression Profiling; Gestationa | 2010 |
Correspondence.
Topics: Adenocarcinoma; Adolescent; Adult; Diethylstilbestrol; Female; Humans; Incidental Findings; Limb Def | 2012 |
[Thalidomide: this "mea culpa" which isn't one].
Topics: Child, Preschool; Dissent and Disputes; Drug Industry; Female; Germany; Humans; Jurisprudence; Limb | 2012 |
Regarding how safe is "safe"?
Topics: Adenocarcinoma; Diethylstilbestrol; Female; Humans; Limb Deformities, Congenital; Pregnancy; Rubella | 2013 |
[Thalidomide epidemics: 50 years after].
Topics: Abnormalities, Drug-Induced; Female; History, 20th Century; Humans; Infant; Limb Deformities, Congen | 2012 |
[Embryopathies caused by thalidomide].
Topics: Extremities; Fetal Diseases; Hypnotics and Sedatives; Limb Deformities, Congenital; Thalidomide | 1962 |
Thalidomide babies. Memorandum from the British Paediatric Association.
Topics: Ethnicity; Extremities; Humans; Hypnotics and Sedatives; Limb Deformities, Congenital; Thalidomide | 1962 |
Thalidomide babies: management of limb defects.
Topics: Artificial Limbs; Disease Management; Extremities; Hypnotics and Sedatives; Limb Deformities, Congen | 1962 |
[Severe congenital abnormalities of the extremities without thalidomide poisoning. A second case in the spotlight].
Topics: Drug-Related Side Effects and Adverse Reactions; Extremities; Hypnotics and Sedatives; Limb Deformit | 1962 |
Habilitation of patients with congenital malformations associated with thalidomide: surgery of limb defects.
Topics: Adolescent; Amputees; Artificial Limbs; Child; Congenital Abnormalities; Ectromelia; Extremities; Hu | 1963 |
Thalidomide and congenital abnormalities.
Topics: Extremities; Hypnotics and Sedatives; Limb Deformities, Congenital; Thalidomide | 1962 |
THE CHILD WITH CONGENITAL LIMB DEFORMITIES.
Topics: Abnormalities, Drug-Induced; Achondroplasia; Arm; Congenital Abnormalities; Ectromelia; Education; F | 1964 |
CONGENITAL ANOMALIES OF THE LIMBS: II. PSYCHOLOGICAL AND EDUCATIONAL ASPECTS.
Topics: Adaptation, Psychological; Adolescent; Artificial Limbs; Biomedical Research; Body Image; Canada; Ch | 1964 |
[Thalidomide embryopathy].
Topics: Abnormalities, Multiple; Extremities; Fetal Diseases; Hypnotics and Sedatives; Limb Deformities, Con | 1962 |
Thalidomide embryopathy.
Topics: Abnormalities, Multiple; Extremities; Fetal Diseases; Hypnotics and Sedatives; Limb Deformities, Con | 1962 |
[Softenon and peromelia].
Topics: Extremities; Hypnotics and Sedatives; Limb Deformities, Congenital; Thalidomide | 1962 |
A novel hypothesis for thalidomide-induced limb teratogenesis: redox misregulation of the NF-kappaB pathway.
Topics: Animals; DNA; Free Radicals; Gene Expression Regulation, Developmental; Glutathione; In Situ Hybridi | 2004 |
Effects of thalidomide on developmental, peri- and postnatal function in female New Zealand white rabbits and offspring.
Topics: Abnormalities, Drug-Induced; Abortifacient Agents; Animals; Animals, Newborn; Body Weight; Dose-Resp | 2004 |
Integrating health information: a case study of a health information service for thalidomide survivors.
Topics: Databases as Topic; Humans; Information Services; Limb Deformities, Congenital; Medical Informatics; | 2007 |
New cases of thalidomide embryopathy in Brazil.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Adult; Brazil; Contraindications; | 2007 |
Thalidomide induces limb anomalies by PTEN stabilization, Akt suppression, and stimulation of caspase-dependent cell death.
Topics: Animals; Apoptosis; Bone Morphogenetic Proteins; Caspases; Cells, Cultured; Chick Embryo; Down-Regul | 2008 |
The thalidomide embryopathy in hybrid rabbits.
Topics: Abnormalities, Drug-Induced; Animals; Cardiovascular Abnormalities; Digestive System Abnormalities; | 1967 |
Recurrence risks of bone aplasias and hypoplasias of the extremities.
Topics: Ectromelia; Female; Hand Deformities, Acquired; Humans; Limb Deformities, Congenital; Radius; Thalid | 1967 |
Effect of thalidomide-derivatives on limb development in culture.
Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Extremities; Female; Limb Deformities, Cong | 1983 |
Thalidomide deformities and their nerve supply.
Topics: Abnormalities, Drug-Induced; Animals; Axons; Extremities; Limb Deformities, Congenital; Rabbits; Sci | 1984 |
A critical review of the McCredie-McBride hypothesis of neural crest influence on limb morphogenesis.
Topics: Animals; Bone and Bones; Chick Embryo; Child; Extremities; Humans; Limb Deformities, Congenital; Neu | 1983 |
Clinical studies on teenage Brazilian victims of thalidomide.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Brazil; Child; Female; Gynecomasti | 1983 |
Infants with congenital limb reduction registered in the Swedish Register of Congenital Malformations.
Topics: Bone and Bones; Female; Humans; Infant, Newborn; Limb Deformities, Congenital; Male; Registries; Swe | 1984 |
Amniotic band sequence in child of thalidomide victim.
Topics: Amniotic Band Syndrome; Female; Hand Deformities, Congenital; Humans; Infant, Newborn; Limb Deformit | 1994 |
Evidence for teratogenicity of thalidomide using congenic and recombinant inbred rat strains.
Topics: Abnormalities, Drug-Induced; Alleles; Animals; Embryonic and Fetal Development; Female; Fetus; Genot | 1994 |
Thalidomide may be a mutagen.
Topics: Abnormalities, Multiple; Fathers; Female; Forearm; Hand Deformities, Congenital; Humans; Infant, New | 1994 |
Mesonephros has a role in limb development and is related to thalidomide embryopathy.
Topics: Animals; Chick Embryo; Extremities; Limb Deformities, Congenital; Mesonephros; Teratogens; Thalidomi | 1996 |
The return of thalidomide: are birth defects surveillance systems ready?
Topics: Abnormalities, Drug-Induced; Child, Preschool; Female; Georgia; Humans; Infant; Infant, Newborn; Lim | 1997 |
Limb deficiencies identified by malformations surveillance programs.
Topics: Abnormalities, Drug-Induced; Humans; Limb Deformities, Congenital; Population Surveillance; Thalidom | 1998 |
Longitudinal limb deficiencies and the sclerotomes. An analysis of 378 dysmelic malformations induced by thalidomide.
Topics: Abnormalities, Drug-Induced; Bone and Bones; Humans; Infant; Limb Deformities, Congenital; Radiograp | 1999 |
Free radical-mediated oxidative DNA damage in the mechanism of thalidomide teratogenicity.
Topics: Animals; Cyclic N-Oxides; DNA Damage; Drug Resistance; Embryo Loss; Embryo, Mammalian; Female; Free | 1999 |
Mechanisms of thalidomide teratogenicity.
Topics: Bone and Bones; Humans; Limb Deformities, Congenital; Osteogenesis; T-Box Domain Proteins; Teratogen | 1999 |
Developmental staging and thalidomide teratogenicity in the green monkey (Cercopithecus aethiops).
Topics: Abnormalities, Drug-Induced; Animals; Chlorocebus aethiops; Female; Gestational Age; Haplorhini; Lim | 1978 |
The use of in vitro procedures in teratology.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Aminopterin; Animals; Azaserine; Bromodeoxyuridine; | 1975 |
Segmental embryonic peripheral neuropathy.
Topics: Abnormalities, Drug-Induced; Animals; Arm; Bone and Bones; Extremities; Humans; Leg; Limb Deformitie | 1975 |
Clinical observations on the thalidomide syndrome.
Topics: Abnormalities, Drug-Induced; Adolescent; Central Nervous System; Child; Female; Genitalia; Humans; L | 1977 |
Linear growth of children with limb deformities following exposure to thalidomide in utero.
Topics: Abnormalities, Drug-Induced; Adolescent; Body Height; Child; Female; Growth; Humans; Limb Deformitie | 1977 |
Sclerotome subtraction: a radiologic interpretation of reduction deformities of the limbs.
Topics: Abnormalities, Drug-Induced; Bone and Bones; Extremities; Humans; Infant, Newborn; Limb Deformities, | 1977 |
Teratology study of two isoglutamine derivatives.
Topics: Abnormalities, Drug-Induced; Animals; Bridged Bicyclo Compounds; Bridged-Ring Compounds; Chemical Ph | 1976 |
Studies of the etiology of thalidomide dysmorphogenesis.
Topics: Abnormalities, Drug-Induced; Animals; Axons; Extremities; Ganglia, Spinal; Limb Deformities, Congeni | 1976 |
Congenital fusion of bones: radiology, embryology and pathogenesis.
Topics: Abnormalities, Drug-Induced; Bone and Bones; Bone Development; Carpal Bones; Cartilage; Child, Presc | 1975 |
The action of thalidomide on the peripheral nervous system of the embryo.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Embryo, Mammalian; Forelimb; Ganglia, Spinal | 1975 |
The pathogenesis of congenital malformations.
Topics: Abnormalities, Drug-Induced; Animals; Child; Extremities; Ganglia, Spinal; Humans; Infant, Newborn; | 1975 |
Recognition of thalidomide defects.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Diagnosis, Differential; Head; Humans; Limb De | 1992 |
Congenital defects of the limbs and alcohol exposure in pregnancy: data from a population based study.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Alcoholism; Animals; British Columbia; Cocaine | 1992 |
Comments on "Proposed Mechanisms of Action in Thalidomide Embryopathy".
Topics: Abnormalities, Drug-Induced; Humans; Limb Deformities, Congenital; Thalidomide | 1990 |
Comments on "Proposed Mechanisms of Action in Thalidomide Embryopathy".
Topics: Abnormalities, Drug-Induced; Humans; Limb Deformities, Congenital; Thalidomide | 1990 |
The obstetric problems of the thalidomide children.
Topics: Cesarean Section; Female; Humans; Infant, Newborn; Limb Deformities, Congenital; Pregnancy; Pregnanc | 1989 |
Embryotoxic effects of thalidomide-derivatives in the non-human primate Callithrix jacchus. I. Effects of 3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-dioxopiperidine (EM12) on skeletal development.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Callithrix; Dose-Response Relationship, Drug; | 1988 |
The role of cholinergic nerves in development.
Topics: Abnormalities, Drug-Induced; Animals; Extremities; Female; Humans; Limb Deformities, Congenital; Par | 1985 |
Teratogen update: clinical aspects of thalidomide embryopathy--a continuing preoccupation.
Topics: Abdomen; Abnormalities, Multiple; Cardiovascular Abnormalities; Cranial Nerves; Dentition; Embryo, M | 1985 |
[Comparative studies on the problem of the further development disorders of the vertebral column in children with dysmelia syndrome and children with peromelia].
Topics: Abnormalities, Drug-Induced; Child; Child, Preschool; Diagnosis, Differential; Ectromelia; Female; H | 1967 |
[Teratologic study of a new, structurally related to thalidomide, sedative-hypnotic effective compound (K-2004)].
Topics: Abdominal Muscles; Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Fetal Death; Her | 1969 |
Swivel walkers. Experiences in fitting swivel walkers to children with severe lower-limb deformities.
Topics: Abnormalities, Multiple; Aluminum; Ankle Joint; Arm; Artificial Limbs; Child; Child, Preschool; Cosm | 1969 |
A morphological and histochemical study of thalidomide-induced upper limb malformations in rabbit fetuses.
Topics: Abnormalities, Drug-Induced; Alkaline Phosphatase; Animals; Bone and Bones; Calcium; Cartilage; Embr | 1971 |
Some congenital abnormalities: possibly due to embryonic peripheral neuropathy.
Topics: Abnormalities, Drug-Induced; Child; Extremities; Female; Humans; Joints; Limb Deformities, Congenita | 1973 |
Limb reduction anomalies induced in the marmoset by thalidomide.
Topics: Abnormalities, Drug-Induced; Animals; Ectromelia; Female; Haplorhini; Limb Deformities, Congenital; | 1972 |
The marmoset as an animal model for teratological research.
Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Disease Models, Animal; Female; Fetu | 1972 |
Sporadic malformations in laboratory animals and their influence on drug testing.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Laboratory; Aspirin; Bone and Bones; Congenital Abnor | 1972 |
The rabbit thalidomide embryopathy.
Topics: Abnormalities, Drug-Induced; Animals; Biliary Tract; Digestive System Abnormalities; Eye Abnormaliti | 1966 |
The teratogenic activity of thalidomide in the rabbit.
Topics: Abnormalities, Drug-Induced; Animals; Eye Abnormalities; Female; Limb Deformities, Congenital; Nervo | 1966 |
[Characteristics of the pathogenic effect of thalidomide on the various stages of development in the chick embryo].
Topics: Abnormalities, Drug-Induced; Animals; Anophthalmos; Brain; Chick Embryo; Eye Abnormalities; Gestatio | 1966 |
An investigation into the teratogenic potential of captan, folpet, and Difolatan in nonhuman primates.
Topics: Abnormalities, Drug-Induced; Animals; Antifungal Agents; Female; Fetus; Haplorhini; Humerus; Indoles | 1971 |
[The medical examination of children with malformations suspected to be due to thalidomide].
Topics: Abnormalities, Drug-Induced; Child; Ear Deformities, Acquired; Humans; Limb Deformities, Congenital; | 1969 |
[Teratologic studies with imipramine in rats and rabbits. Planning and interpretation of teratologic studies under consideration of the biochemistry and toxicology of test substance].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Body Weight; Desipramine; Drug Toleranc | 1969 |
[Abnormalities of internal organs in thalidomide embryopathy. A contribution to the determination of the sensitivity phase in thalidomide administration during early pregnancy].
Topics: Abnormalities, Drug-Induced; Adult; Digestive System Abnormalities; Ear Deformities, Acquired; Femal | 1967 |
The acceptance and rejection of prostheses by children with multiple congenital limb deformities.
Topics: Abnormalities, Multiple; Adaptation, Psychological; Age Factors; Arm; Artificial Limbs; Child, Presc | 1968 |
Reconstructive surgery of major congenital skeletal deformities of the limbs.
Topics: Abnormalities, Drug-Induced; Amputation, Surgical; Child, Preschool; Fibula; Foot Deformities, Conge | 1969 |
Dysmelia. A classification and a pattern of malformation in a group of congenital defects of the limbs.
Topics: Bone and Bones; Child; Congenital Abnormalities; Ectromelia; Femur; Humans; Humerus; Limb Deformitie | 1969 |
Hazards to the newlyborn infant from thalidomide-containing drugs administered to pregnant mothers. (Report on three cases).
Topics: Abnormalities, Drug-Induced; Female; Humans; Infant; Limb Deformities, Congenital; Male; Pregnancy; | 1966 |