thalidomide has been researched along with Congenital Hand Deformities in 12 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Thalidomide was taken in the sensitive period of the pregnancy by the father's mother." | 4.80 | Unilateral terminal aphalangia in father and daughter--exogenous or genetic cause? ( Kunze, J; Neumann, L; Pelz, J, 1998) |
| "We have recently shown that Okihiro syndrome results from mutation in the putative zinc finger transcription factor gene SALL4 on chromosome 20q13." | 1.32 | Mutations at the SALL4 locus on chromosome 20 result in a range of clinically overlapping phenotypes, including Okihiro syndrome, Holt-Oram syndrome, acro-renal-ocular syndrome, and patients previously reported to represent thalidomide embryopathy. ( Becker, K; Kohlhase, J; Liebers, M; Mohammed, SN; Newbury-Ecob, R; Rauch, A; Reardon, W; Schubert, L, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (50.00) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kohlhase, J | 1 |
| Schubert, L | 1 |
| Liebers, M | 1 |
| Rauch, A | 1 |
| Becker, K | 1 |
| Mohammed, SN | 1 |
| Newbury-Ecob, R | 1 |
| Reardon, W | 1 |
| Oshima, Y | 1 |
| Okutsu, I | 1 |
| Hamanaka, I | 1 |
| Motomura, T | 1 |
| Tenconi, R | 1 |
| Clementi, M | 1 |
| Notari, L | 1 |
| Lo Vasco, VR | 1 |
| Kida, M | 1 |
| McBride, WG | 1 |
| Neumann, L | 1 |
| Pelz, J | 1 |
| Kunze, J | 1 |
| Grosse, FR | 1 |
| Wiedemann, H | 1 |
| Ruffing, L | 1 |
| Hertel, E | 1 |
| Smith, RJ | 1 |
| Holt, SB | 1 |
| Lamb, DW | 1 |
| Sharrard, WJ | 1 |
2 reviews available for thalidomide and Congenital Hand Deformities
| Article | Year |
|---|---|
Unilateral terminal aphalangia in father and daughter--exogenous or genetic cause?
Topics: Adult; Fathers; Female; Fingers; Forearm; Genes, Dominant; Hand Deformities, Congenital; Humans; Inf | 1998 |
Syndromes with reduction and surplus anomalies of the hand.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Fanconi Syndrome; Female; Fingers; Hand Deform | 1977 |
10 other studies available for thalidomide and Congenital Hand Deformities
| Article | Year |
|---|---|
Mutations at the SALL4 locus on chromosome 20 result in a range of clinically overlapping phenotypes, including Okihiro syndrome, Holt-Oram syndrome, acro-renal-ocular syndrome, and patients previously reported to represent thalidomide embryopathy.
Topics: Abnormalities, Multiple; Base Sequence; Chromosomes, Human, Pair 20; DNA; DNA Mutational Analysis; D | 2003 |
Carpal tunnel syndrome accompanying radial dysplasia due to thalidomide embryopathy.
Topics: Abnormalities, Drug-Induced; Adult; Carpal Tunnel Syndrome; Endoscopy; Female; Hand Deformities, Con | 2006 |
Amniotic band sequence in child of thalidomide victim.
Topics: Amniotic Band Syndrome; Female; Hand Deformities, Congenital; Humans; Infant, Newborn; Limb Deformit | 1994 |
Thalidomide may not be a mutagen.
Topics: Hand Deformities, Congenital; Humans; Male; Mutagenesis; Thalidomide | 1994 |
Thalidomide may be a mutagen.
Topics: Abnormalities, Multiple; Fathers; Female; Forearm; Hand Deformities, Congenital; Humans; Infant, New | 1994 |
[Problems of treating the clubhand in dysmelia syndrome (thalidomide-embryopathy)].
Topics: Abnormalities, Drug-Induced; Arthrodesis; Bone Development; Child; Follow-Up Studies; Forearm; Hand; | 1976 |
Preventive surgery for congenital deformities of the hand.
Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Female; Fetus; Genetic Engineering; | 1985 |
The effect of absence of thumb on palmar dermatoglyphics.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Dermatoglyphics; Hand Deformities, Congenital; | 1972 |
The treatment of radial club hand. Absent radius, aplasia of the radius, hypoplasia of the radius, radial paraxial hemimelia.
Topics: Abnormalities, Drug-Induced; Carpal Bones; Child, Preschool; Contracture; Hand; Hand Deformities, Co | 1972 |
Reconstructive surgery of major congenital skeletal deformities of the limbs.
Topics: Abnormalities, Drug-Induced; Amputation, Surgical; Child, Preschool; Fibula; Foot Deformities, Conge | 1969 |