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thalidomide and Congenital Hand Deformities

thalidomide has been researched along with Congenital Hand Deformities in 12 studies

Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.

Research Excerpts

ExcerptRelevanceReference
" Thalidomide was taken in the sensitive period of the pregnancy by the father's mother."4.80Unilateral terminal aphalangia in father and daughter--exogenous or genetic cause? ( Kunze, J; Neumann, L; Pelz, J, 1998)
"We have recently shown that Okihiro syndrome results from mutation in the putative zinc finger transcription factor gene SALL4 on chromosome 20q13."1.32Mutations at the SALL4 locus on chromosome 20 result in a range of clinically overlapping phenotypes, including Okihiro syndrome, Holt-Oram syndrome, acro-renal-ocular syndrome, and patients previously reported to represent thalidomide embryopathy. ( Becker, K; Kohlhase, J; Liebers, M; Mohammed, SN; Newbury-Ecob, R; Rauch, A; Reardon, W; Schubert, L, 2003)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19906 (50.00)18.7374
1990's4 (33.33)18.2507
2000's2 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kohlhase, J1
Schubert, L1
Liebers, M1
Rauch, A1
Becker, K1
Mohammed, SN1
Newbury-Ecob, R1
Reardon, W1
Oshima, Y1
Okutsu, I1
Hamanaka, I1
Motomura, T1
Tenconi, R1
Clementi, M1
Notari, L1
Lo Vasco, VR1
Kida, M1
McBride, WG1
Neumann, L1
Pelz, J1
Kunze, J1
Grosse, FR1
Wiedemann, H1
Ruffing, L1
Hertel, E1
Smith, RJ1
Holt, SB1
Lamb, DW1
Sharrard, WJ1

Reviews

2 reviews available for thalidomide and Congenital Hand Deformities

ArticleYear
Unilateral terminal aphalangia in father and daughter--exogenous or genetic cause?
    American journal of medical genetics, 1998, Jul-24, Volume: 78, Issue:4

    Topics: Adult; Fathers; Female; Fingers; Forearm; Genes, Dominant; Hand Deformities, Congenital; Humans; Inf

1998
Syndromes with reduction and surplus anomalies of the hand.
    Birth defects original article series, 1977, Volume: 13, Issue:1

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Fanconi Syndrome; Female; Fingers; Hand Deform

1977

Other Studies

10 other studies available for thalidomide and Congenital Hand Deformities

ArticleYear
Mutations at the SALL4 locus on chromosome 20 result in a range of clinically overlapping phenotypes, including Okihiro syndrome, Holt-Oram syndrome, acro-renal-ocular syndrome, and patients previously reported to represent thalidomide embryopathy.
    Journal of medical genetics, 2003, Volume: 40, Issue:7

    Topics: Abnormalities, Multiple; Base Sequence; Chromosomes, Human, Pair 20; DNA; DNA Mutational Analysis; D

2003
Carpal tunnel syndrome accompanying radial dysplasia due to thalidomide embryopathy.
    Journal of hand surgery (Edinburgh, Scotland), 2006, Volume: 31, Issue:3

    Topics: Abnormalities, Drug-Induced; Adult; Carpal Tunnel Syndrome; Endoscopy; Female; Hand Deformities, Con

2006
Amniotic band sequence in child of thalidomide victim.
    BMJ (Clinical research ed.), 1994, Nov-26, Volume: 309, Issue:6966

    Topics: Amniotic Band Syndrome; Female; Hand Deformities, Congenital; Humans; Infant, Newborn; Limb Deformit

1994
Thalidomide may not be a mutagen.
    BMJ (Clinical research ed.), 1994, Sep-17, Volume: 309, Issue:6956

    Topics: Hand Deformities, Congenital; Humans; Male; Mutagenesis; Thalidomide

1994
Thalidomide may be a mutagen.
    BMJ (Clinical research ed.), 1994, Jun-18, Volume: 308, Issue:6944

    Topics: Abnormalities, Multiple; Fathers; Female; Forearm; Hand Deformities, Congenital; Humans; Infant, New

1994
[Problems of treating the clubhand in dysmelia syndrome (thalidomide-embryopathy)].
    Handchirurgie, 1976, Volume: 8, Issue:4

    Topics: Abnormalities, Drug-Induced; Arthrodesis; Bone Development; Child; Follow-Up Studies; Forearm; Hand;

1976
Preventive surgery for congenital deformities of the hand.
    Hand clinics, 1985, Volume: 1, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Female; Fetus; Genetic Engineering;

1985
The effect of absence of thumb on palmar dermatoglyphics.
    Journal of medical genetics, 1972, Volume: 9, Issue:4

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Dermatoglyphics; Hand Deformities, Congenital;

1972
The treatment of radial club hand. Absent radius, aplasia of the radius, hypoplasia of the radius, radial paraxial hemimelia.
    The Hand, 1972, Volume: 4, Issue:1

    Topics: Abnormalities, Drug-Induced; Carpal Bones; Child, Preschool; Contracture; Hand; Hand Deformities, Co

1972
Reconstructive surgery of major congenital skeletal deformities of the limbs.
    Developmental medicine and child neurology, 1969, Volume: 11, Issue:2

    Topics: Abnormalities, Drug-Induced; Amputation, Surgical; Child, Preschool; Fibula; Foot Deformities, Conge

1969