thalidomide has been researched along with Complications, Pregnancy in 57 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thalidomide is widely used for several diseases; however, it causes malformations in embryos exposed during pregnancy." | 7.91 | The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis. ( Fraga, LR; Gomes, JDA; Kowalski, TW; Macedo, GS; Sanseverino, MTV; Schuler-Faccini, L; Vianna, FSL, 2019) |
| "The pregnancy was complicated by dialysis difficulties, uncontrollable hypertension and deteriorating renal function resulting in fetal loss at 26-weeks' gestation." | 5.28 | Thalidomide, pregnancy and renal failure. ( Brown, MA; Child, RP; Farrell, C; Newton, P, 1990) |
| "The widely accepted standard therapy for cutaneous sarcoidosis includes corticosteroids, antimalarials, and methotrexate." | 4.84 | Cutaneous sarcoidosis therapy updated. ( Badgwell, C; Rosen, T, 2007) |
| " Thalidomide was taken in the sensitive period of the pregnancy by the father's mother." | 4.80 | Unilateral terminal aphalangia in father and daughter--exogenous or genetic cause? ( Kunze, J; Neumann, L; Pelz, J, 1998) |
| "Thalidomide is widely used for several diseases; however, it causes malformations in embryos exposed during pregnancy." | 3.91 | The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis. ( Fraga, LR; Gomes, JDA; Kowalski, TW; Macedo, GS; Sanseverino, MTV; Schuler-Faccini, L; Vianna, FSL, 2019) |
| "Environmental causes of birth defects have increasingly been recognized since the mid-20th century." | 2.47 | Causes of birth defects: lessons from history. ( Lancaster, PA, 2011) |
| "Cases with documented maternal alcohol abuse in pregnancy in this group were analyzed separately." | 1.28 | Congenital defects of the limbs and alcohol exposure in pregnancy: data from a population based study. ( Baird, PA; Froster, UG, 1992) |
| "The pregnancy was complicated by dialysis difficulties, uncontrollable hypertension and deteriorating renal function resulting in fetal loss at 26-weeks' gestation." | 1.28 | Thalidomide, pregnancy and renal failure. ( Brown, MA; Child, RP; Farrell, C; Newton, P, 1990) |
| "Goiter is relatively common in infants whose mothers were treated with propylthiouracil and other antithyroid drugs, yet they usually show normal thyroid function." | 1.25 | Human experiences related to adverse drug reactions to the fetus or neonate from some maternally administered drugs. ( Shirkey, HC, 1972) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (66.67) | 18.7374 |
| 1990's | 7 (12.28) | 18.2507 |
| 2000's | 5 (8.77) | 29.6817 |
| 2010's | 6 (10.53) | 24.3611 |
| 2020's | 1 (1.75) | 2.80 |
| Authors | Studies |
|---|---|
| Foulon, A | 1 |
| Chevreau, J | 1 |
| Yzet, C | 1 |
| Gondry, J | 1 |
| Fumery, M | 1 |
| Gomes, JDA | 1 |
| Kowalski, TW | 1 |
| Fraga, LR | 1 |
| Macedo, GS | 1 |
| Sanseverino, MTV | 1 |
| Schuler-Faccini, L | 1 |
| Vianna, FSL | 1 |
| Kmietowicz, Z | 1 |
| Kouros, N | 1 |
| Cozzani, E | 1 |
| Gasparini, G | 1 |
| Parodi, A | 1 |
| Verma, R | 1 |
| Vasudevan, B | 1 |
| Pragasam, V | 1 |
| Moorchung, N | 1 |
| Mitra, D | 1 |
| Gopal, M | 1 |
| Hou, JK | 1 |
| Mahadevan, U | 1 |
| Lancaster, PA | 1 |
| NULSEN, RO | 1 |
| HEYNE, D | 1 |
| ROBSON, JM | 1 |
| VOTAVA, Z | 1 |
| WALKER, J | 1 |
| COHLAN, SQ | 1 |
| PINCHERLE, M | 1 |
| GAROFANO, I | 1 |
| MONIE, IW | 1 |
| DELERUE, J | 1 |
| FELISATI, D | 1 |
| ARENA, JM | 1 |
| CONNELLY, JP | 1 |
| REYNOLDS, S | 1 |
| CRAWFORD, JD | 1 |
| TALBOT, NB | 1 |
| KISTNER, RW | 1 |
| HUBER, A | 1 |
| KELSEY, FO | 2 |
| Badgwell, C | 1 |
| Rosen, T | 1 |
| Benegbi, M | 1 |
| Stevens, RJ | 1 |
| Koren, G | 1 |
| Pastuszak, A | 1 |
| Ito, S | 1 |
| Neumann, L | 1 |
| Pelz, J | 1 |
| Kunze, J | 1 |
| Zeldis, JB | 1 |
| Williams, BA | 1 |
| Thomas, SD | 1 |
| Elsayed, ME | 1 |
| Schulte-Wissermann, H | 1 |
| Yaffe, SJ | 1 |
| Froster, UG | 1 |
| Baird, PA | 1 |
| Mair, J | 1 |
| Brown, MA | 1 |
| Farrell, C | 1 |
| Newton, P | 1 |
| Child, RP | 1 |
| Chamberlain, G | 1 |
| Maouris, PG | 1 |
| Hirsch, PJ | 1 |
| Onishi, T | 1 |
| Shirkey, HC | 1 |
| Fratta, ID | 1 |
| Morgon, A | 1 |
| Charachon, D | 2 |
| Bringuier, N | 1 |
| Sugiyama, Y | 1 |
| Yager, JW | 1 |
| Jackson, BT | 1 |
| Murad, JE | 1 |
| Tuchmann-Duplessis, H | 1 |
| Watanabe, G | 1 |
| Rasore-Quartino, A | 1 |
| Rovei, S | 1 |
| Hauser, GA | 1 |
| Mambourg, A | 1 |
| Gibbels, E | 1 |
| Hammarström, L | 1 |
| Henrikson, CO | 1 |
| Larsson, KS | 1 |
| Lenz, W | 1 |
| Morgon, MA | 1 |
| Gordon, H | 1 |
| Sinclair, JG | 1 |
| Abreu, BE | 1 |
| Piotrowski, J | 1 |
17 reviews available for thalidomide and Complications, Pregnancy
| Article | Year |
|---|---|
[IBD and pregnancy: From conception to birth].
Topics: Cesarean Section; Colitis, Ulcerative; Crohn Disease; Delivery, Obstetric; Female; Fertilization; Fe | 2020 |
Pyoderma gangrenosum: a systematic review.
Topics: Anti-Inflammatory Agents; Arthritis; Dermatologic Agents; Diagnosis, Differential; Disease Progressi | 2014 |
Causes of birth defects: lessons from history.
Topics: Abnormalities, Drug-Induced; Animals; Australia; Congenital Abnormalities; Female; Fever; History, 2 | 2011 |
THE PROBLEM OF TERATOGENICITY.
Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Cyclizine; Female; Imipramine; Nicotine; Preg | 1963 |
ADVANCES IN OBSTETRICS AND GYNAECOLOGY.
Topics: Anemia; Endocrinology; Erythroblastosis, Fetal; Female; Genital Neoplasms, Female; Gynecology; Hormo | 1963 |
TERATOGENIC AGENTS AND CONGENITAL MALFORMATIONS.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Aminopterin; Congenital Abnormalities; Female; | 1963 |
Cutaneous sarcoidosis therapy updated.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Allopurinol; Animals; Anti-Inflammatory Agents | 2007 |
Drugs in pregnancy.
Topics: Abnormalities, Drug-Induced; Animals; Counseling; Dicyclomine; Doxylamine; Drug Combinations; Drug E | 1998 |
Unilateral terminal aphalangia in father and daughter--exogenous or genetic cause?
Topics: Adult; Fathers; Female; Fingers; Forearm; Genes, Dominant; Hand Deformities, Congenital; Humans; Inf | 1998 |
[Experimental congenital heart diseases].
Topics: Animals; Chickens; Cricetinae; Dactinomycin; Disease Models, Animal; Dogs; Female; Folic Acid Defici | 1972 |
[Several problems of drug therapy in pregnancy].
Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Antineoplastic Agents; Antitubercular Agents; Ca | 1971 |
Congenital malformations and environmental influence: the occupational environment of laboratory workers.
Topics: Abnormalities, Drug-Induced; Anesthetics; Anti-Bacterial Agents; Benzene; California; Congenital Abn | 1973 |
Drugs in pregnancy and their effects on pre- and postnatal development.
Topics: Abnormalities, Drug-Induced; Alkylating Agents; Animals; Anticonvulsants; Antimetabolites; Central N | 1973 |
The pathogenesis of congenital cardiovascular anomalies.
Topics: Abnormalities, Drug-Induced; Animals; Azo Compounds; Embryology; Female; Heart; Heart Defects, Conge | 1968 |
[Teratogenic molecules].
Topics: Abnormalities, Drug-Induced; Animals; Drug-Related Side Effects and Adverse Reactions; Female; Human | 1967 |
[Experimental epidemiology].
Topics: Animals; Chromosome Aberrations; Chromosome Disorders; Cleft Palate; Congenital Abnormalities; Diabe | 1971 |
Malformations caused by drugs in pregnancy.
Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Cyclophosphamide; Female; Humans; Infant, Newborn | 1966 |
40 other studies available for thalidomide and Complications, Pregnancy
| Article | Year |
|---|---|
The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis.
Topics: Abnormalities, Multiple; Acetyltransferases; Brazil; Cell Line; Chromosomal Proteins, Non-Histone; C | 2019 |
More drug studies need to include pregnant women, says bulletin.
Topics: Anticonvulsants; Clinical Trials as Topic; Drug Industry; Female; Humans; Hypnotics and Sedatives; M | 2013 |
Cases of babies in Brazil born with thalidomide defects.
Topics: Abnormalities, Drug-Induced; Brazil; Drug Repositioning; Ethics, Pharmacy; Female; Humans; Infant; M | 2013 |
Bullous erythema nodosum leprosum manifesting in the post partum period with unusual features.
Topics: Adult; Erythema Nodosum; Female; Humans; Leprostatic Agents; Leprosy, Borderline; Leprosy, Lepromato | 2015 |
A 24-year-old pregnant woman with inflammatory bowel disease.
Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Breast Feeding; Crohn Disease; Female; Fetus; Huma | 2009 |
Trial of thalidomide in insomnia associated with the third trimester.
Topics: Female; Humans; Hypnotics and Sedatives; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Th | 1961 |
[Initial statistical elements relative to congenital malformations in Belgium].
Topics: Belgium; Biometry; Congenital Abnormalities; Diabetes Mellitus; Female; Humans; Pregnancy; Pregnancy | 1963 |
[CONTINUOUS RISE IN THE INCIDENCE OF PHOCOMELIA IN NEWBORN INFANTS IN WESTERN EUROPE AND ITS RELATION TO THALIDOMIDE ADMINISTRATION. CURRENT STATUS OF THE PROBLEM].
Topics: Abnormalities, Drug-Induced; Drug Tolerance; Ectromelia; Europe; Female; Germany; Germany, West; Inc | 1963 |
[PHOCOMELIA SYNDROME CAUSED BY THALIDOMIDE].
Topics: Ectromelia; Female; Infant, Newborn; Pregnancy; Pregnancy Complications; Radiography; Syndrome; Thal | 1963 |
INFLUENCE OF THE ENVIRONMENT ON THE UNBORN.
Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Communicable Diseases; Congenital Abnormalities; | 1963 |
[TERATOGENIC ACTION OF DRUGS IN THE PREGNANT WOMAN].
Topics: Abnormalities, Drug-Induced; Antineoplastic Agents; Avitaminosis; Chlorpromazine; Cortisone; Female; | 1963 |
TERATOGENIC ACTION OF THALIDOMIDE.
Topics: Abnormalities, Drug-Induced; Female; Folic Acid; Glutamine; Niacinamide; Pregnancy; Pregnancy Compli | 1964 |
REPORT FROM THE DUKE UNIVERSITY POISON CONTROL CENTER. DRUG DANGERS (MATERNAL MEDICATION) TO THE FETUS.
Topics: Abnormalities, Drug-Induced; Aminopterin; Anti-Bacterial Agents; Antimetabolites; Chloramphenicol; C | 1964 |
VIRAL AND DRUG HAZARDS IN PREGNANCY.
Topics: Abnormalities, Drug-Induced; Androgens; Chickenpox; Congenital Abnormalities; Female; Hand Deformiti | 1964 |
HAZARDS OF OBSTETRICAL AND GYNECOLOGICAL DRUGS.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Androgens; Drug Therapy; Estrogens; Female; Gy | 1964 |
[CHONDRODYSTROPHY AFTER THALIDOMIDE MEDICATION].
Topics: Abnormalities, Drug-Induced; Bone Diseases, Developmental; Drug Therapy; Ectromelia; Enchondromatosi | 1964 |
PROBLEMS RAISED FOR THE FDA BY THE OCCURRENCE OF THALIDOMIDE EMBRYOPATHY IN GERMANY, 1960-1961.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Drug Industry; Female; Fetal Diseases; Germany | 1965 |
Lenalidomide (Revlimid) for anemia of myelodysplastic syndrome.
Topics: Anemia; Chromosome Deletion; Chromosomes, Human, Pair 5; Contraindications; Female; Humans; Lenalido | 2006 |
45 years later...where do we stand?
Topics: Abnormalities, Drug-Induced; Canada; Drug-Related Side Effects and Adverse Reactions; Female; Foreca | 2007 |
The place of thalidomide in the treatment of inflammatory disease.
Topics: Abnormalities, Drug-Induced; Anti-Inflammatory Agents, Non-Steroidal; Contraindications; Cytokines; | 1996 |
S.T.E.P.S.: a comprehensive program for controlling and monitoring access to thalidomide.
Topics: Dermatologic Agents; Drug and Narcotic Control; Drug Monitoring; Female; Humans; Immunosuppressive A | 1999 |
[The Contergan (Thalidomide) case. Catastrophic consequences].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Female; Humans; Hypnotics and Sedatives; Infan | 2000 |
A clinical look at the problem of drugs in pregnancy and their effect on the fetus.
Topics: Abnormalities, Drug-Induced; Anesthesia, Obstetrical; Aspirin; Drug-Related Side Effects and Adverse | 1975 |
Congenital defects of the limbs and alcohol exposure in pregnancy: data from a population based study.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Alcoholism; Animals; British Columbia; Cocaine | 1992 |
Foetal life and a legal duty of care.
Topics: Abnormalities, Drug-Induced; Female; Fetus; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male | 1991 |
Thalidomide, pregnancy and renal failure.
Topics: Adult; Antihypertensive Agents; Combined Modality Therapy; Female; Humans; Hypertension; Kidney Fail | 1990 |
The obstetric problems of the thalidomide children.
Topics: Cesarean Section; Female; Humans; Infant, Newborn; Limb Deformities, Congenital; Pregnancy; Pregnanc | 1989 |
Pregnancy in women with thalidomide-induced disabilities. Case report and a questionnaire study.
Topics: Abnormalities, Drug-Induced; Adult; Cesarean Section; Ectromelia; Female; Humans; Infant, Newborn; P | 1988 |
Human experiences related to adverse drug reactions to the fetus or neonate from some maternally administered drugs.
Topics: Abnormalities, Drug-Induced; Antineoplastic Agents; Antithyroid Agents; Contraceptives, Oral; Diethy | 1972 |
Nicotinamide deficiency and thalidomide: potential teratogenic disturbances in Long-Evans rats.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Animal Feed; Animals; Birth Weight; Chlorproma | 1969 |
Disorders of the auditory apparatus caused by embryopathy or foetopathy: prophylaxis and treatment (a) deafness as a result of congenital malformations occurring during the first three months (b) deafness resulting from diseases of the foetus occurring af
Topics: Child, Preschool; Deafness; Ear; Ear, Inner; Female; Humans; Pregnancy; Pregnancy Complications; Rad | 1971 |
[The teratogenic risk].
Topics: Abnormalities, Drug-Induced; Animals; Azathioprine; Busulfan; Carbutamide; Congenital Abnormalities; | 1968 |
[A case of thalidomide anotia].
Topics: Abnormalities, Drug-Induced; Ataxia; Blepharoptosis; Child; Ear; Eye Abnormalities; Female; Humans; | 1967 |
[Drugs during pregnancy].
Topics: Antineoplastic Agents; Calcium; Coumarins; Ergot Alkaloids; Female; Hormones; Humans; Iron; Pregnanc | 1971 |
[Toxic injuries in thalidomide medication].
Topics: Adult; Depression; Female; Humans; Male; Middle Aged; Polyneuropathies; Pregnancy; Pregnancy Complic | 1967 |
Anomalies of the teeth in a child with upper phocomelia. Report of a case.
Topics: Abnormalities, Drug-Induced; Arm; Child; Ectromelia; Face; Female; Humans; Male; Pregnancy; Pregnanc | 1970 |
[Lesions of the auditory apparatus during pregnancy].
Topics: Abnormalities, Drug-Induced; Animals; Bacterial Infections; Deafness; Drug-Related Side Effects and | 1970 |
Genetical, social, and medical aspects of abortion.
Topics: Abnormalities, Drug-Induced; Abortion, Criminal; Abortion, Legal; Abortion, Therapeutic; Adolescent; | 1968 |
Transplacental effects of drugs in mice.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Male; Maternal-Fetal Exchange; Methylcell | 1965 |
[Considerations on the occurrence of human abnormalities].
Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Environment; Environmental Exposure; Female; | 1966 |